Co-administration of α-lipoic acid and cyclosporine aggravates colon ulceration of acetic acid-induced ulcerative colitis via facilitation of NO/COX-2/miR-210 cascade

El‐Gowelli, Hanan M.; Saad, Evan I.; Abdel-Galil, Abdel-Galil A; Ibrahim, Einas R.

doi:10.1016/j.taap.2015.08.002

Cited by 14 publications

(49 citation statements)

References 72 publications

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“…47 showed that ALA (different doses) significantly reduced the TNF-α content in tissue or the plasma during the treatment course and afterward when compared with the control group. 50,51,54 El-Goweli et al 50 found that ALAtreated group with a potency similar to cyclosporine (CSA) and their combination decreased the TNF-α level significantly when compared with the control. Three out of 10 studies have assessed the TNF-α level following ALA administration compared with the controls in rats.…”

Section: Resultsmentioning

confidence: 99%

“…49 The comparison of ALA with CSA or their combination proved that both of these compounds improved the experimental markers (aforementioned parameters) in a similar manner rather than placebo and ALA was superior to CSA or their combination in increasing the GSH level. [49][50][51] In addition, AL-1 in a dose-dependent manner reduced the TNF-α, IL-6, COX-2, MPO, macroscopic score, and DAI levels in colitis mice. [49][50][51] In addition, AL-1 in a dose-dependent manner reduced the TNF-α, IL-6, COX-2, MPO, macroscopic score, and DAI levels in colitis mice.…”

Section: Discussionmentioning

confidence: 99%

“…46 In colitis mice, the GSH level enhanced noticeably following the ALA treatment (particular doses) compared with the control (Table 1). [50][51][52][53][54] The positive impact of the ALA administration, oral or intraperitoneal (IP), on the GSH generation, was confirmed by Kolgazi et al 53 (Table 2). [50][51][52][53][54] The positive impact of the ALA administration, oral or intraperitoneal (IP), on the GSH generation, was confirmed by Kolgazi et al 53 (Table 2).…”

Section: Effect Of Ala In Comparison Withmentioning

confidence: 92%

“…46 According to Sun et al, 46 ALA significantly inhibited the increase of MDA compared with placebo ( Table 1). 50 Moura et al 54 (2016) illustrated that ALA alone or in combination with F I G U R E 4 Individual and pooled effect size for the outcome of "ΔMPO" in the studies considering ALA compared with placebo therapy in UC in 32 rats. 50-54 Sehirli et al 51 and Kolgazi et al 53 showed that ALA treatment significantly lessened the MDA level in rat UC model, where administered orally or intraperitoneally compared with the control.…”

Section: Effect Of Ala In Comparison With Placebo Therapy On Mda Inmentioning

confidence: 99%

“…55 3.15 | Effect of ALA and AL-1 in comparison with placebo therapy on colon length in induced UC among mice or rats ALA did not show any significant inhibitory effects on shortening of the colon length in DSS-induced colitis mouse model compared to the control. 50 Yang et al 55 revealed that the administration of AL-1 improved the colon length in the UC-induced mice. In addition, ALA restored normal colon weight/length ratio in acetic acid-induced UC in rats.…”

Section: Effect Of Ala In Comparison Withmentioning

confidence: 99%

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Effects of alpha lipoic acid and its derivative “andrographolid‐lipoic acid‐1” on ulcerative colitis: A systematic review with meta‐analysis of animal studies

Moeinian

Abdolghaffari

Nikfar

et al. 2018

J of Cellular Biochemistry

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We aimed to review and meta‐analyze the inflammatory and oxidative factors following alpha lipoic acid (ALA) and its derivative “andrographolid‐lipoic acid‐1” (AL‐1) in ulcerative colitis (UC). ALA plays an important role in scavenging intracellular radicals and inflammatory elements. AL‐1 is found in herbal medicines with potent anti‐inflammatory properties. Data were collected from the Google Scholar, PubMed, Scopus, Evidence‐based medicine/clinical trials, and Cochrane library database until 2017, which finally resulted in 22 animal studies (70 rats and 162 mice). The beneficial effects of ALA or AL‐1 on the most important parameters of UC were reviewed; also, studies were considered separately in mice and rats. Administration of ALA and AL‐1 significantly reduced the tumor necrosis factor‐α level compared with the controls, while data were not noteworthy in the meta‐analysis (mean differences = −18.57 [95% CI = −42.65 to 5.51], P = 0.13). In spite of insignificant decrease in meta‐analysis outcomes (differences = 6.92 [95% CI = −39.33 to 53.16], P = 0.77), a significant reduction in myeloperoxidase activity was shown following ALA or AL‐1 treatment compared with the controls. Despite significant differences in each study, we had to exclude some studies to homogenize data for meta‐analyzing as they showed insignificant results. Interleukin 6, cyclooxygenase‐2, glutathione, malondialdehyde, superoxide dismutase, histopathological score, macroscopic and microscopic scores, disease activity index, body weight change, and colon length were also reviewed. Most studies have emphasized on significant positive effects of ALA and AL‐1. Comprehensive clinical trials are obligatory to determine the precious position of ALA or AL‐1 in the management of UC.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Effect Of Ala In Comparison Withmentioning

confidence: 92%

Section: Effect Of Ala In Comparison With Placebo Therapy On Mda Inmentioning

confidence: 99%

Section: Effect Of Ala In Comparison Withmentioning

confidence: 99%

See 3 more Smart Citations

Effects of alpha lipoic acid and its derivative “andrographolid‐lipoic acid‐1” on ulcerative colitis: A systematic review with meta‐analysis of animal studies

Moeinian

Abdolghaffari

Nikfar

et al. 2018

J of Cellular Biochemistry

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An Extracellular Matrix‐Liposome Composite, a Novel Extracellular Matrix Delivery System for Accelerated Tissue Regeneration

Lee

Nguyen

Setiawati

et al. 2021

Adv Healthcare Materials

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The unfolded states of fibronectin (FN) subsequently induce the formation of an extracellular matrix (ECM) fibrillar network, which is necessary to generate new substitutive tissues. Here, the authors demonstrate that negatively charged small unilamellar vesicles (SUVs) qualify as candidates for FN delivery due to their remarkable effects on the autonomous binding and unfolding of FN, which leads to increased tissue regeneration. In vitro experiments revealed that the FN-SUV complex remarkably increased the attachment, differentiation, and migration of fibroblasts. The potential utilization of this complex in vivo to treat inflammatory colon diseases is also described based on results obtained for ameliorated conditions in rats with ulcerative colitis (UC) that had been treated with the FN-SUV complex. Their findings provide a new ECM-delivery platform for ECM-based therapeutic applications and suggest that properly designed SUVs may be an unprecedented FN-delivery system that is highly effective in treating UC and inflammatory bowel diseases.

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Role of MiRNAs in Inflammatory Bowel Disease

Cao

Zhou

et al. 2017

Dig Dis Sci

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Inflammatory bowel diseases (IBD), mainly including Crohn's disease and ulcerative colitis, are characterized by chronic inflammation of the gastrointestinal tract. Despite improvements in detection, drug treatment and surgery, the pathogenesis of IBD has not been clarified. A number of miRNAs have been found to be involved in the initiation, development and progression of IBD, and they may have the potential to be used as biomarkers and therapeutic targets. Here, we have summarized the recent advances about the roles of miRNAs in IBD and analyzed the contribution of miRNAs to general diagnosis, differential diagnosis and activity judgment of IBD. Furthermore, we have also elaborated the promising role of miRNAs in IBD-related cancer prevention and prognosis prediction.

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Co-administration of α-lipoic acid and cyclosporine aggravates colon ulceration of acetic acid-induced ulcerative colitis via facilitation of NO/COX-2/miR-210 cascade

Cited by 14 publications

References 72 publications

Effects of alpha lipoic acid and its derivative “andrographolid‐lipoic acid‐1” on ulcerative colitis: A systematic review with meta‐analysis of animal studies

Effects of alpha lipoic acid and its derivative “andrographolid‐lipoic acid‐1” on ulcerative colitis: A systematic review with meta‐analysis of animal studies

An Extracellular Matrix‐Liposome Composite, a Novel Extracellular Matrix Delivery System for Accelerated Tissue Regeneration

Role of MiRNAs in Inflammatory Bowel Disease

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