Role of MiRNAs in Inflammatory Bowel Disease

Cao, Bo; Zhou, Xin; Ma, Jiaojiao; Zhou, Wei; Yang, Wanli; Fan, Daiming; Hong, Liu

doi:10.1007/s10620-017-4567-1

Cited by 47 publications

(41 citation statements)

References 117 publications

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“…For further detail about miRNAs, both mammalian enteritis related and novel miRNAs have been found. The current miRNA results contain the IBD related miRNAs, such as miR-10, which could down-regulate mucosal inflammatory response in DC, and miR-132, which was revealed to enhance the cholinergic anti-inflammatory pathway via regulation on AchE (acetylcholinesterase) (Cao et al, 2017 ). This also predicted the inhibiting role of novel 280 and novel 179 on CD276, which may suggest their therapeutic potential.…”

Section: Discussionmentioning

confidence: 99%

Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver

Wang

Cui

et al. 2018

Front. Physiol.

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In aquafeeds, fish-meal has been commonly replaced with plant protein, which often causes enteritis. Currently, foodborne enteritis has few solutions in regards to prevention or cures. The recovery mechanism from enteritis in herbivorous fish may further help understand prevention or therapy. However, few reports could be found regarding the recovery or resilience to fish foodborne enteritis. In this study, grass carp was used as an animal model for soybean meal induced enteritis and it was found that the fish could adapt to the soybean meal at a moderate level of substitution. Resilience to soybean meal stress was found in the 40% soybean meal group for juvenile fish at growth performance, morphological and gene expression levels, after a 7-week feeding trial. Furthermore, the intestinal transcriptomic data, including transcriptome and miRNAome, was applied to demonstrate resilience mechanisms. The result of this study revealed that in juvenile grass carp after a 7-week feeding cycle with 40% soybean meal, the intestine recovered via enhancing both an immune tolerance and wound healing, the liver gradually adapted via re-balancing immune responses, such as phagosome and complement cascades. Also, many immune factors in the gut and liver were systemically revealed among stages of on-setting, remising, and recovering (or relief). In addition, miRNA regulation played a key role in switching immune states. Thus, the present data systemically demonstrated that the molecular adaptation mechanism of fish gut-liver immunity is involved in the resilience to soybean meal stress.

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Section: Discussionmentioning

confidence: 99%

Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver

Wang

Cui

et al. 2018

Front. Physiol.

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“…Although the pathogenesis of CD is still unclear, accumulating evidence shows that environmental factors, genetics, autoimmunity, and dietary habits may contribute to its development and progression[ 24 , 25 ]. As an important genetic factor, miRNA dysregulation is involved in the aetiological mechanism of several autoimmune diseases, including CD[ 26 ]; however, the role of miR-125a/b expression in CD risk and management is largely unstudied[ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn’s disease

Sun¹,

Wu²,

Zhang³

et al. 2017

WJG

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AIMTo determine the association of circulating miR-125a/b expression with the risk and disease severity of Crohn’s disease (CD), and with inflammatory cytokines.METHODSPlasma samples were collected from patients with active CD (A-CD), or CD in remission (R-CD) and from healthy controls (HCs). The levels of the inflammatory cytokines interleukin-17 (IL-17), tumour necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were measured by enzyme-linked immunosorbent assay. The expression of miR-125a/b was assessed by quantitative polymerase chain reaction (qPCR).RESULTSTwenty-nine A-CD patients, 37 R-CD patients, and 37 HCs were included in the study. Plasma miR-125a expression was decreased in A-CD patients compared with that in R-CD patients (P < 0.001) and HCs (P < 0.001). miR-125a expression levels enabled the differentiation of A-CD from R-CD patients [area under curve (AUC) = 0.854] and from HCs (AUC = 0.780), whereas miR-125b expression did not. miR-125a was negatively correlated with C-reaction protein (CRP) (P = 0.017), erythrocyte sedimentation rate (ESR) (P = 0.026), Crohn’s disease activity index (CDAI) (P = 0.003), IL-17 (P = 0.015), and TNF-α (P = 0.004) in A-CD patients. Furthermore, miR-125a was negatively associated with CRP (P = 0.038) and CDAI (P = 0.021) in R-CD patients. Regarding miR-125b, no association with CRP, CDAI, IL-17, TNF-α, or IFN-γ was found in A-CD or in R-CD patients. miR-125a levels gradually increased in A-CD patients who achieved clinical remission (P = 0.009) after 3-mo treatment, whereas they remained unchanged among patients who failed to achieve remission. No changes in miR-125b expression were detected in remission or non-remission patients after treatment.CONCLUSIONCirculating miR-125a but not miR-125b is decreased in patients with active disease status and negatively correlates with disease severity and inflammatory cytokines in patients with CD.

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“…Hence, miRNAs hold great promise as potential non-invasive diagnostic markers. miRNAs are dysregulated in IBD 64. Therefore, researchers have attempted to demonstrate the diagnostic value of circulating miRNAs signatures in the blood as diagnostic biomarkers using machine learning modelling, including random forests and SVM 65 66…”

Section: Current Paradigm Of Ibd Disease Management and Its Limitationsmentioning

confidence: 99%

Big data in IBD: big progress for clinical practice

Tabib

Madgwick

Sudhakar³

et al. 2020

Gut

139

108

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IBD is a complex multifactorial inflammatory disease of the gut driven by extrinsic and intrinsic factors, including host genetics, the immune system, environmental factors and the gut microbiome. Technological advancements such as next-generation sequencing, high-throughput omics data generation and molecular networks have catalysed IBD research. The advent of artificial intelligence, in particular, machine learning, and systems biology has opened the avenue for the efficient integration and interpretation of big datasets for discovering clinically translatable knowledge. In this narrative review, we discuss how big data integration and machine learning have been applied to translational IBD research. Approaches such as machine learning may enable patient stratification, prediction of disease progression and therapy responses for fine-tuning treatment options with positive impacts on cost, health and safety. We also outline the challenges and opportunities presented by machine learning and big data in clinical IBD research.

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Role of MiRNAs in Inflammatory Bowel Disease

Cited by 47 publications

References 117 publications

Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver

Integrative Transcriptomic and microRNAomic Profiling Reveals Immune Mechanism for the Resilience to Soybean Meal Stress in Fish Gut and Liver

Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn’s disease

Big data in IBD: big progress for clinical practice

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