CNS Involvement in Pancreatic Adenocarcinoma: a Report of Eight Cases from the Johns Hopkins Hospital and Review of Literature

Kumar, Abhijeet; Dagar, Meenakshi; Herman, Joseph M.; Iacobuzio‐Donahue, Christine A.; Laheru, Dan

doi:10.1007/s12029-014-9667-y

Cited by 23 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 Cerebral metastases of pancreatic carcinoma, in contrast, are rather rare but still documented in the literature. 47 Lastly, the movie 50/50 27 portrays a tumor of the lumbar spine, a schwannoma. Like the astrocytoma in the movie Phenomenon, 26 the protagonist also benefits from his condition in an unrealistic way, freeing himself from his unhappy relationship.…”

Section: Neuro-oncologymentioning

confidence: 99%

Neurosurgery in Contemporary Medical Dramas: How Grey's Anatomy & Co. May Affect Perception of Neurosurgery in the Media

Pilz

Stummer

Holling

2020

J Neurol Surg A Cent Eur Neurosurg

View full text Add to dashboard Cite

Background Neurosurgery is a common topic in contemporary medical dramas. This study aimed to examine depictions of several neurosurgical diseases and techniques as well as the perception of the personality of neurosurgeons in the media, focusing on their impact on the physician-patient relationship. Methods TV series and movies with a main focus on neurosurgeons and/or neurosurgical diseases were identified by consulting the International Movie Database (IMDb). Results After investigation of many TV series and movies, we identified five main topics: vascular neurosurgery, neuro-oncology, neurointensive care, neurosurgical techniques, and neurosurgeon's personality. The portrayal of neurosurgery in medical drama is characterized to a large extent by sensationalism, a lot of misinformation, and an unfavorable portrayal of neurosurgeons, although it is assumed that expert advice was sought in advance of every production. Conclusions Considering the popularity of medical dramas and movies dealing with medical topics, we must consider the general public's picture of neurosurgery to be widely influenced by the media.

show abstract

Section: Neuro-oncologymentioning

confidence: 99%

Neurosurgery in Contemporary Medical Dramas: How Grey's Anatomy & Co. May Affect Perception of Neurosurgery in the Media

Pilz

Stummer

Holling

2020

J Neurol Surg A Cent Eur Neurosurg

View full text Add to dashboard Cite

show abstract

“…The same was true for serum hemoglobin. Other reports have also suggested that patients with gastric or pancreatic cancer constitute a minority of GI cancer patients who develop brain metastases [20,21]. Thirty-one percent of the patients analyzed by Sperduto et al [1] had KPS 90-100, compared to only 23% of our patients.…”

Section: Discussionmentioning

confidence: 45%

Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA)

et al. 2020

View full text Add to dashboard Cite

Purpose: The purpose of this study was to validate a new prognostic model (GI-GPA) originally derived from a multi-center database (USA, Canada, Japan). Patients and Methods: This retrospective study included 92 German and Norwegian patients treated with individualized approaches, always including brain radiotherapy. Information about age, extracranial spread, number of brain metastases, performance status and other variables was collected. The GI-GPA score was calculated as described by Sperduto et al. Results: Median survival was 4 months. The corresponding figures for the 4 different prognostic strata were 2.3, 4.4, 9.4 and 12.7 months, respectively (p = 0.0001). Patients whose management included surgical resection had longer median survival than those who were treated with other approaches (median 11.9 versus 3.0 months, p = 0.002). Comparable results were seen for additional systemic therapy (median 8.5 versus 3.5 months, p = 0.01). Conclusion: These results confirm the validity of the GI-GPA in an independent dataset from a different geographical region, despite the fact that overall survival was shorter in all prognostic strata, compared to Sperduto et al. Potential explanations include differences in molecular tumor characteristics and treatment selection, both brain metastasesdirected and extracranially. Long-term survival beyond 5 years is possible in a small minority of patients.

show abstract

“…Treatment modalities for cranial pathology include resection followed by radiation, resection alone, or WBRT 2. Lemke et al recommend resection of metastatic lesions of pancreatic adenocarcinomas as a treatment strategy or potentially as a cure 6.…”

Section: Discussionmentioning

confidence: 99%

“…However, spread of disease to the brain is exceedingly rare and has an incidence of 0.33%–0.57% in antemortem cases as compared with 7.9% in postmortem diagnoses 2. This may be due to the short life expectancy which limits time for manifestation of neurological symptoms.…”

Section: Introductionmentioning

confidence: 99%

Metastatic pancreatic adenocarcinoma presenting as an occipital haemorrhage

Ng¹,

How

Schwindack

et al. 2018

BMJ Case Reports

View full text Add to dashboard Cite

We report a case of a 63-year-old woman who was presented to the emergency department with an occipital haemorrhage secondary to a pancreatic cerebral metastasis. Pancreatic cancer is the ninth most common cancer in women in Australia, and distant disease is present in 70% of patients with pancreatic cancer at the time of diagnosis. However, metastases to the brain are rare, accounting for only 0.33%-0.57% cases antemortem. Herein, we discuss the management of this unusual case to highlight the importance of recognising unusual central nervous system involvement of cancers, a problem which may be increasing in prevalence.

show abstract

CNS Involvement in Pancreatic Adenocarcinoma: a Report of Eight Cases from the Johns Hopkins Hospital and Review of Literature

Cited by 23 publications

References 15 publications

Neurosurgery in Contemporary Medical Dramas: How Grey's Anatomy & Co. May Affect Perception of Neurosurgery in the Media

Neurosurgery in Contemporary Medical Dramas: How Grey's Anatomy & Co. May Affect Perception of Neurosurgery in the Media

Validation of the graded prognostic assessment for gastrointestinal cancers with brain metastases (GI-GPA)

Metastatic pancreatic adenocarcinoma presenting as an occipital haemorrhage

Contact Info

Product

Resources

About