CNS activities of liquid and spray-dried extracts from Lippia alba—Verbenaceae (Brazilian false melissa)

Zétola, M; Lima, Thereza Christina Monteiro de; Sonaglio, Diva; González‐Ortega, George; Limberger, Renata Pereira; Petrovick, Pedro Ros; Bassani, V. L.

doi:10.1016/s0378-8741(02)00187-3

Cited by 57 publications

(41 citation statements)

References 25 publications

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“…Lippia alba occurs in all regions of Brazil (Zétola et al, 2002;Oliveira et al, 2006;Neto et al, 2009;Cunha et al, 2010;Teles et al, 2012;Vale et al, 2012;Soares et al, 2016). Due to its genetic variation, wide geographical distribution and exposure to different soil and weather conditions, and distinct seasons of collection, L. alba can produce EOs with different chemical composition, which expresses the occurrence of distinct chemotypes (Pascual et al, 2001;Hennebelle et al, 2008;Maffei et al, 2011;Teles et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Physiological responses of Rhamdia quelen (Siluriformes: Heptapteridae) to anesthesia with essential oils from two different chemotypes of Lippia alba

et al. 2017

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The aim of this study was to evaluate if Lippia alba has different chemotypes according to the chemical composition of the essential oil (EO) considering collection site, and if the EO may have different effects on blood and plasma parameters in silver catfish, Rhamdia quelen, during and immediately after anesthesia. The citral (EO-C) and linalool (EO-L) chemotypes were identified, and both presented similar anesthetic effects for silver catfish. Fish were exposed to two concentrations of each EO, which induced slow and fast anesthesia (100 and 300 µL L -1 , respectively). Blood ions did not change at any time of anesthesia induction and recovery and, therefore, the electrolyte balance was not altered. Blood gases oscillated through all exposure and recovery times, but there was an increase in pO 2 after 10 min recovery in fish anesthetized with EO-C. Glucose increased in fish exposed to both EOs when compared with the control group. Overall, exposure to both EOs (except 100 µL L -1 EO-L at most times) reduced plasma cortisol levels compared to the control and/or ethanol groups. However, as plasma creatinine levels in fish anesthetized with EO-C were higher than control fish, the use of EO-L is preferable.Keywords: Blood gas, Cortisol, Glucose, Plasma ions, Silver Catfish.O objetivo deste estudo foi avaliar se Lippia alba apresenta diferentes quimiotipos de acordo com a composição química do óleo essencial (OE), considerando local de coleta e se o OE causa diferentes efeitos nos parâmetros sanguíneos e plasmáticos em jundiá, Rhamdia quelen, durante e imediatamente após a anestesia. Os quimiotipos citral (OE-C) e linalol (OE-L) foram identificados e ambos apresentaram efeito anestésico semelhante para jundiá. Os peixes foram expostos a duas concentrações de cada OE, que induziram anestesia lenta e rápida (100 e 300 mL L -1 , respectivamente). Íons sanguíneos não se alteraram em nenhum tempo e consequentemente, o equilíbrio eletrolítico não foi alterado. Os gases sanguíneos oscilaram durante todo tempo de exposição e recuperação, mas houve aumento na pO 2 após 10 min de recuperação em peixes anestesiados com OE-C. Níveis sanguíneos de glicose aumentaram nos peixes expostos a ambos OEs quando comparados com o grupo controle. De um modo geral, a exposição a ambos OEs (exceto 100 µL L -1 OE-L na maioria dos tempos) reduziu o cortisol plasmático comparado aos grupos controle e etanol. No entanto, como os níveis de creatinina plasmática em peixes anestesiados com OE-C foram maiores que nos peixes controle, é preferível o uso do OE-L.

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Section: Introductionmentioning

confidence: 99%

Physiological responses of Rhamdia quelen (Siluriformes: Heptapteridae) to anesthesia with essential oils from two different chemotypes of Lippia alba

et al. 2017

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“…Brown (Verbenaceae) is an aromatic shrub widely distributed in South America, that grows in sandy soils on the margin of rivers, lakes and ponds (Moldenk 1965). This species is used in folk Brazilian medicine as sedative, carminative, spasmolitic, emanogoge, sudorific, antidysenteric, antireumatic, antihypertensive and expectorant (Corręa 1992;Di Stasi & Huruma-Lima 2002;Lorenzi & Matos 2002;Zétola et al 2002;Zoghbi et al 1998). This species shows a great phenotypical plasticity (Montanari et al 2004) and a great variation in essential oil constituents, being divided into different chemotypes (Matos 1996).…”

Section: Introductionmentioning

confidence: 99%

Chromosome banding and essential oils composition of Brazilian accessions of Lippia alba (Verbenaceae)

et al. 2009

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Abstract:The essential oil components and a karyotypic analysis of five Lippia alba (Verbenaceae) accessions from Brazil were performed with the objective of investigating the variation among different populations. The chemistry analysis allowed the grouping of the accessions in two main chemotypes: neral chemotype (LaCat, LaJF and LaRJ) and linalool chemotype (LaGua and LaVC). However, large karyotypic differences, verified by different chromosome banding techniques, were not detected. The results presented the same chromosome number for all accessions (2n = 30) with 10 metacentric chromosomes and 5 submetacentric. The chromosome banding showed great blocks of constitutive heterochromatin (C-bands) around the centromeric region, which was rich in AT bases (DAPI+), while the CMA bands were observed only in terminal regions of six chromosomes. Through Ag-NOR techniques, only two active pairs of NORs were detected on the three pairs of secondary constrictions (the NOR activity is discussed). This work relates the pattern of heterochromatin for Lippia alba for the first time.

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“…N.E.Br., contendo diferentes proporções de dióxido de silício coloidal, polisorbato 80 e β-ciclodextrina, concluiu-se que apenas o extrato contendo unicamente dióxido de silício coloidal como adjuvante apresentou efeitos sedativos próximos ao extrato fluído. O processo de secagem não alterou as propriedades sedativas, porém, no que tange aos adjuvantes de secagem utilizados, estes exerceram influência sobre as mesmas (Zétola et al, 2002).…”

Section: Aplicações Da Técnica E Sua Interferência Na Qualidade Dos Punclassified

Secagem por aspersão (spray drying) de extratos vegetais: bases e aplicações

Oliveira¹,

Petrovick²

2010

Rev. bras. farmacogn.

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RESUMO:A maioria dos medicamentos fitoterápicos registrados no Brasil apresenta-se sob a forma farmacêutica sólida, utilizando extratos secos como principal matéria-prima ativa. A técnica de secagem por aspersão (spray drying) tem sido amplamente aplicada na obtenção de extratos secos com melhores características tecnológicas e maior concentração de constituintes com atividade biológica. As propriedades físico-químicas dos produtos produzidos por spray drying são influenciadas por fatores relacionados ao processo, à formulação (material de entrada) e ao equipamento. Nesta revisão são apresentados e discutidos resultados de trabalhos relacionados a parâmetros de processo e formulação, e as aplicações da técnica com enfoque no desenvolvimento de extratos secos oriundos de vegetais, principalmente da flora medicinal brasileira.Unitermos: Secagem por aspersão, produtos naturais, extratos secos, processo.ABSTRACT: "Spray drying of plant extracts: basic remarks and application". In Brazil, the majority of the approved phytomedicines are formulated as solid dosage forms containing plant dried extracts as active component. Spray drying technique has been widely used to obtain dried extracts presenting better technological characteristics and greater concentration of biological active constituents. Physicochemical properties of such products depend on factors related to process, formulation (inlet material) and equipment. This review presents and discusses some studies related to parameters of process and formulation, as well as some technical applications focusing on the development of dried extract from plants, mainly from the Brazilian medicinal flora.

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CNS activities of liquid and spray-dried extracts from Lippia alba—Verbenaceae (Brazilian false melissa)

Cited by 57 publications

References 25 publications

Physiological responses of Rhamdia quelen (Siluriformes: Heptapteridae) to anesthesia with essential oils from two different chemotypes of Lippia alba

Physiological responses of Rhamdia quelen (Siluriformes: Heptapteridae) to anesthesia with essential oils from two different chemotypes of Lippia alba

Chromosome banding and essential oils composition of Brazilian accessions of Lippia alba (Verbenaceae)

Secagem por aspersão (spray drying) de extratos vegetais: bases e aplicações

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