“…Citral, another major component of EOCL, increased barbituric sleeping time of mice (Vale et al, 2002) and blocks the excitability of rat sciatic nerves (Sousa et al, 2015). Citral is also the main component of other EOs that have anesthetic effects in fish: Aloysia triphylla (Gressler et al, 2012;Parodi et al, 2014;Santos et al, 2017 Cymbopogon flexuosus (Limma-Neto et al, 2016) and L. alba citral chemotype (Souza et al, 2017). The anesthetic effects of citral in fish does not involve the benzodiazepine site of the GABAergic system γ-terpinene, also a major component of EOCL, increases dopamine release from rat brain striatum slices (Fukumoto et al, 2006), but to our knowledge, no study so far has analyzed the sedative and/or anesthetic activities of this compound.…”