2021
DOI: 10.3389/fendo.2021.672557
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CMR-Verified Myocardial Fibrosis Is Associated With Subclinical Diastolic Dysfunction in Primary Aldosteronism Patients

Abstract: ObjectivesThe main cardiac features of primary aldosteronism (PA) are impaired left ventricular (LV) diastolic function, and some articles also reported more cardiac fibrosis in PA patients. However, the correlation between LV dysfunction and diffuse myocardial fibrosis in PA remains unknown.MethodsWe enrolled 84 PA patients and 28 essential hypertension (EH) patients in West China Hospital. Cardiac magnetic resonance imaging (CMR) contrast enhancement was arranged for all subjects. Postcontrast T1 time and le… Show more

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Cited by 6 publications
(3 citation statements)
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References 41 publications
(56 reference statements)
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“…вносит вклад в патофизиологию ремоделирования миокарда и церебральных сосудов, способствует развитию хронической сердечной недостаточности, усугубляет последствия ишемии головного мозга [33][34][35][36].…”
Section: артериальная гипертензияunclassified
“…вносит вклад в патофизиологию ремоделирования миокарда и церебральных сосудов, способствует развитию хронической сердечной недостаточности, усугубляет последствия ишемии головного мозга [33][34][35][36].…”
Section: артериальная гипертензияunclassified
“…Moreover, CMR has become the imaging method of choice to assess myocardial fibrosis thanks to the uncontestable advantages deriving from CMR in accurate tissue characterization [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ].…”
Section: Cmr and Ccta Imagingmentioning
confidence: 99%
“…VE: ventrículo esquerdo. Em 2020, Redheuil e colaboradores publicaram um artigo de prova de conceito (58) que também não encontrou diferença significativa nos valores Também em 2021, Zhou e colaboradores (60) compararam apenas pacientes hipertensos com HAS e HAP pareados por nível pressórico, com curta duração da doença e já em uso de tratamento anti-hipertensivo, porém houve descontinuidade do uso de drogas interferindo no SRAA antes do exame de RMC. Nessa coorte, onde a massa ventricular esquerda era semelhante entre os grupos, o excesso de aldosterona foi associado a prolongamento do T1 nativo e expansão do VEC, caracterizando fibrose intersticial.…”
Section: Análise Estatísticaunclassified