Clustering patterns of metabolic syndrome: A cross-sectional study in children and adolescents in Kyiv

Aliusef, Maiia H.; Gnyloskurenko, Ganna V; Churylina, Alina V.; Mityuryayeva, Inga

doi:10.3389/fped.2022.972975

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…In physiological conditions, leptin stimulates the oxidation of FFAs and the uptake of glucose, thus preventing the accumulation of lipids in non-adipose tissues. When the abundance of FFAs is no longer compensated by leptin activity, they are shifted to the nonoxidative metabolic pathway and detrimental metabolites able to induce β cells death are produced [ 26 , 33 , 34 ]. Another adipokine strongly related to the pathogenesis of MetS is adiponectin, which is known to exert a variety of protective functions on metabolism and to induce an anti-inflammatory effect via inhibition of TLRs and secretion of anti-inflammatory cytokines [ 15 – 17 , 28 , 29 , 32 ].…”

Section: Modifiable Risk Factors Of Mets In Childhood and Adolescencementioning

confidence: 99%

Mechanisms and risk factors of metabolic syndrome in children and adolescents

Codazzi,

Frontino,

Galimberti

et al. 2023

Endocrine

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Metabolic syndrome (MetS) is a complex disorder characterized by abdominal obesity, elevated blood pressure, hyperlipidemia, and elevated fasting blood glucose levels. The diagnostic criteria for MetS in adults are well-established, but there is currently no consensus on the definition in children and adolescents. The etiology of MetS is believed to involve a complex interplay between genetic predisposition and environmental factors. While genetic predisposition explains only a small part of MetS pathogenesis, modifiable environmental risk factors play a significant role. Factors such as maternal weight during pregnancy, children’s lifestyle, sedentariness, high-fat diet, fructose and branched-chain amino acid consumption, vitamin D deficiency, and sleep disturbances contribute to the development of MetS. Early identification and treatment of MetS in children and adolescents is crucial to prevent the development of chronic diseases later in life. In this review we discuss the latest research on factors contributing to the pathogenesis of MetS in children, focusing on non-modifiable and modifiable risk factors, including genetics, dysbiosis and chronic low-grade inflammation.

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Section: Modifiable Risk Factors Of Mets In Childhood and Adolescencementioning

confidence: 99%

Mechanisms and risk factors of metabolic syndrome in children and adolescents

Codazzi,

Frontino,

Galimberti

et al. 2023

Endocrine

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show abstract

“…Ñë³ä çàçíà÷èòè, ùî IDF -öå ºäèíå âèçíà÷åííÿ, â ÿêîìó àáäîì³íàëüíå îaeèð³ííÿ º îáîâ'ÿçêîâèì êðèòåð³ºì. Íàäàííÿ ïåðâèííîñò³ â ä³àãíîñòèö³ âèì³ðþâàííþ îêðóaeíîñò³ òàë³¿ º íàóêîâî îá-´ðóíòîâàíèì ÷èñëåííèìè äîñë³äaeåííÿìè [9,10,11]. Òàê, çã³äíî ç ìåòà-àíàë³çîì 2018 ðîêó, ä³òè ç³ ñï³ââ³äíîøåííÿì îêðóaeíîñò³ òàë³¿ äî çðîñòó (WtHR) ≥0,5 ìàþòü â÷åòâåðî âèùèé ðèçèê êëàñòåðíèõ êðèòåð³¿â ÌÑ ³ ùî öåé ðèçèê âèïðàâäîâóº ïî÷àòîê ïðîô³ëàêòè÷íèõ çàõîä³â [12].…”

Section: âñòóïunclassified

“…It should be noted that the IDF is the only definition in which abdominal obesity is a mandatory criterion. The primary diagnostic role of waist circumference measurement is scientifically supported by numerous studies [9,10,11]. For example, according to a 2018 meta-analysis, children with a waist-to-height ratio (WHtR) ≥ 0.5 have a fourfold higher risk of meeting cluster criteria for MetS, and this risk justifies the initiation of preventive measures [12].…”

Section: ñLinical Characteristics Of Children and Adolescents With Me...mentioning

confidence: 99%

Сlinical Characteristics of Children and Adolescents With Metabolic Syndrome in Kyiv

Aliusef,

Churylina

2023

AML

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This study aimed to clinically evaluate children and adolescents with metabolic syndrome (MetS) in order to identify and diagnose the condition at an early stage and prevent possible complications. Materials and Methods. A comprehensive examination of 105 children aged 10 to 17 years with MetS was conducted at the Rheumatology and Cardiology Department of Children's Clinical Hospital No. 6 in Kyiv. The International Diabetes Federation (IDF) criteria were used to establish MetS. Anthropometric assessments included calculation of body mass index, evaluation of waist circumference using age-specific percentile charts, determination of waist-to-height ratio (WHtR), and measurement of neck circumference in lying and standing positions. Ambulatory blood pressure monitoring was performed using the ABM-04 device (Meditech, Hungary), and laboratory investigations (glucose, insulin, lipid profile) were conducted using the Cobas 6000 analyzer and test system (Roche Diagnostics). The EZR version 1.61 (November 11, 2022) package was used for statistical analysis of the obtained data. Results and Discussion. In terms of heredity analysis, the presence of hypertension in the father of children, maternal grandmother, and mother was the most common, indicating the importance of genetic influence on the development of this condition. Among the most common complaints were elevated blood pressure, headaches, anxiety, and palpitations. The logistic regression model demonstrated that daytime sleepiness was associated with symptoms such as sweating, morning hoarseness, tinnitus, weather sensitivity, and fatigue. There was no statistically significant difference between the manifestations of acanthosis nigricans and purple stretch marks in girls and boys, but a higher tendency was observed in males. Conclusions. Metabolic syndrome in children and adolescents is associated with a high risk of complications, as most of them have a high WHtR value. Cardiovascular diseases showed the highest hereditary dependency in close relatives of children with MetS. Cardiovascular symptoms are the most common among children with MetS, but girls had significantly higher frequencies of emotional and psychological symptoms.

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Cardiorespiratory Monitoring of Children and Adolescents With Metabolic Syndrome Aged 10-17 Years: A Cross-Sectional Descriptive Study

Aliusef,

Churylina,

Mitiuriaeva

et al. 2023

EUMJ

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Study objectives. This study aims to investigate potential differences in sleep parameters between children with metabolic syndrome (MetS) and their healthy counterparts using the portable cardiorespiratory monitoring device SOMNOcheck micro CARDIO. Methods. The study included 71 children and adolescents aged 10 to 17 years, with 39 in the MetS group and 32 in the control group. The main anthropometric parameters were: neck circumference (NC), waist circumference (WC) and waist-to-height ratio (WHtR). All children were assessed using the Friedman tongue position (FTP) scale. Children completed the Epworth Sleepiness Scale for Children and Adolescents (ESS-CHAD) and the Montreal Cognitive Assessment (MoCA). Salivary cortisol was collected in the morning immediately after waking up. The sleep study was performed using a portable SOMNOcheck micro CARDIO device with a special cardiaс sensor. Statistical analysis of the data was performed using EZR version 1.61. Results. Significant differences in cardiorespiratory sleep monitoring were observed between between the MetS and non-MetS groups. Patients with MetS had higher daytime sleepiness scores and lower MoCA scores compared to the control group. Cortisol levels in morning saliva showed a marked increase among children with obstructive apnea/hypopnea index ≥ 1. A logistic regression model established a link between FTP stages III and IV and the autonomous arousal index. Conclusions. These findings highlight the differences (p < 0.05) in sleep-related parameters between the MetS and non-MetS groups, which may indicate an increased risk of sleep-disordered breathing and cognitive impairment in such children.

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Clustering patterns of metabolic syndrome: A cross-sectional study in children and adolescents in Kyiv

Cited by 4 publications

References 24 publications

Mechanisms and risk factors of metabolic syndrome in children and adolescents

Mechanisms and risk factors of metabolic syndrome in children and adolescents

Сlinical Characteristics of Children and Adolescents With Metabolic Syndrome in Kyiv

Cardiorespiratory Monitoring of Children and Adolescents With Metabolic Syndrome Aged 10-17 Years: A Cross-Sectional Descriptive Study

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