Clusterin and psoriasis, what is the relation?

Abstract

Background: Psoriasis is a chronic inflammatory immunologically mediated disease characterized by antigen presentation and keratinocytes hyperproliferation due to release of chemokines and cytokines from activated T-lymphocytes. Relationship between psoriasis and peripheral vascular diseases, increased risk of myocardial infarction and cerebrovascular diseases has been reported. Clusterin [apolipoprotein J] is a 75-80 KDa disulfide-linked heterodimeric protein associated with apoptosis and clearance of cellular debris. Clusterin [CLU] is involved in many diseases related to oxidative stress, including neurodegenerative and inflammatory diseases. Aim of the work: The aim of this study is to estimate the serum level of clusterin in patients with severe plaque psoriasis to evaluate its possible role in psoriasis pathogenesis and comorbidity. Patients and methods: Sixty patients with severe plaque psoriasis having Psoriasis Area Severity Index [PASI] score more than 10 and Thirty healthy individuals as control were studied by enzyme linked immunosorbent assay for determination of serum clusterin levels. Results: Serum levels of clusterin showed statistically significant increase in psoriatic patients than in controls. Conclusion: Psoriatic patients show increase clusterin serum level compared with normal controls. This indicates that it may have a potential role in the pathogenesis of psoriasis and may be related to increase risk of cardiovascular diseases among psoriatic patients.

Serum clusterin in psoriasis: relation to metabolic syndrome

“…This is not consistent with Hashem et al that suggest that serum clusterin levels were higher than controls and suggest the presence of psoriasis-metabolic syndrome pathogenic interactions and with Zhu et al who concluded that serum values of clusterin were increased in the premature form of coronary artery disease. 12,13,15 Comparing between psoriatic patients having metabolic syndrome and psoriatic patients having no metabolic syndrome revealed no significant difference in clusterin serum levels. This matches with Garcia-Rodriguez et al who however said that clusterin levels are decreased in psoriatic patients than controls, but also found that there was no difference in its levels in patients haning and having no metabolic syndrome.…”

“…With no significant correlation in clusterin level with other studied parameters in all psoriasis cases. 10,13 The results obtained by Garcia-Rodriguez et al observed that plasma clusterin was reduced in psoriasis patients compared with healthy controls but the study had a small sample size. 14 In this study there was a comparison between psoriatic patients with metabolic syndrome and controls where there were differences in correlation to any other parameter.…”

“…These results don't match with Hashem et al who suggested that clusterin level showed a significant correlation with PASI score and it could be a useful marker for severity of the disease. 13 Kyrylowicz et al refered elevated levels of clusterin to its defensive role against the inflammation associated with psoriasis. 17 on another hand, increased rate of cardio vascular diseases in psoriasis is associated with elevated levels of proinflammatory cytokines like tumor necrosis factor-alpha, interleukin 1, and cardiotropin-1.…”

Regulation of psoriasis, colitis, and the intestinal microbiota by clusterin

“…HaCaT cells, immortalized human keratinocytes, also produce clusterin 24 . Serum clusterin levels are higher in patients with psoriasis than in healthy controls 25 , 26 , and the clusterin mRNA level in skin lesions from patients with psoriasis is different from that in normal controls 27 . However, little is known about how clusterin affects the inflammatory reactions associated with psoriasis.…”