Clusterin: a protein with multiple functions as a potential ionizing radiation exposure marker

Early effects of carbon-ion irradiation on murine lymphocytes and thymocytes

“…In BALB/c mice, it has been demonstrated that the spleen serves several important roles during irradiation, including being a site for the development of protective and pathological immune responses following irradiation (Kraal et al, 1989;Weiss, 1989). Some reports also concluded that the level of protein in spleen and splenocyte apoptotic bodies had significant increases after dose of 5.0 or 7.5 Gy (Amer, 1993;Klokov et al, 2003).…”

“…As we know, different organs have different radiosensitives. It is reported massive cell death appeared at 48 h after radiation in spleen (Klokov et al, 2003), and thymus is one of the more radiosensitive tissues (Altman et al, 1970), and we studied the acute reaction of radiation. So we selected the 24 h as the sampling time.…”