Cluster headache

Bahra, Anish; May, Arne; Goadsby, Peter J.

doi:10.1212/wnl.58.3.354

Cited by 495 publications

(673 citation statements)

References 72 publications

(50 reference statements)

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“…Yet, for rs1800759 the mutant allele seems to be less common in the Italian cohorts (31.0%–33.7%) compared with our Swedish cohort (42.3%). From our questionnaire data, 56.2% of the patients reported that alcohol may trigger an attack which corresponds to what other groups have reported (52%–63%) 7, 8, 9. When performing a statistical analysis for control individuals and CH patients reporting alcohol as a trigger factor, there were no significant differences in the genotypes of the two groups for either SNP.…”

Section: Discussionsupporting

confidence: 83%

“…However, already in 1941 Bayard Horton observed that alcohol may elicit an attack in CH patients during the active phase 5. More recently, it has been reported that 52%‐79% of the patients experience alcohol to trigger an attack when in a bout 6, 7, 8, 9. However, the study reporting a frequency of 79% included only male patients with episodic CH 6.…”

Section: Introductionmentioning

confidence: 99%

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Screening of Two ADH4 Variations in a Swedish Cluster Headache Case–Control Material

et al. 2016

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BackgroundCluster headache (CH) is a severe neurovascular disorder and an increasing amount of evidence points to a genetic contribution to this disease. When CH was first described, it was observed that alcohol may precipitate an attack during the active phase of the disease. The alcohol dehydrogenase 4 (ADH4) gene encodes an enzyme which contributes to the metabolization of alcohol and is, therefore, an interesting candidate gene for CH. Two Italian groups have reported association of the single nucleotide polymorphism (SNP) rs1126671 located in the ADH4 gene with an increased risk of CH in Italy. In addition, one of the groups found an association between the ADH4 SNP rs1800759 and CH.ObjectiveTo perform a replication study on the ADH4 SNPs rs1126671 and rs1800759 in a large homogeneous Swedish case–control cohort in order to further investigate the possible contribution of ADH4 to CH.MethodsA total of 390 unrelated patients diagnosed with CH and 389 controls representing a general Swedish population were recruited to the study. DNA samples from patients and controls were genotyped for the two ADH4 SNPs rs1126671 and rs1800759 using quantitative real‐time polymerase chain reaction. Statistical analyses of genotype, allele and haplotype frequencies for the two SNPs were performed and compared between patients and controls.ResultsFor rs1126671, the minor allele frequency (A allele) was 32.8% (n = 254) in controls compared with 31.9% (n = 249) in CH patients. The minor allele frequency (A allele) of rs1800759 was 42.3% (n = 324) in controls and 41.9% (n = 327) in CH patients. Statistical analysis showed no significant differences in allele as well as in genotype or haplotype frequencies between the patient and control group for either SNP. This was also seen after stratifying the patient group for experiencing alcohol as a trigger factor.ConclusionsThe data did not support an association of the ADH4 SNPs rs1126671 and rs1800759 with CH. A comparison with previous studies revealed variance in genotype, allele, and haplotype frequencies among the different populations which might contribute to the contradictory results. Although a significant association with CH in Swedish case–control group was not found, ADH4 as a candidate gene for CH could not be excluded.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Screening of Two ADH4 Variations in a Swedish Cluster Headache Case–Control Material

et al. 2016

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“…The findings of the two patients who began complaining of CH symptoms at an uncommon age (11 and 70 years) are noteworthy, although similar cases have been previously reported 19 . The proportion of episodic and chronic patterns of CH in this sample (approximately 4:1) is also concordant with most studies 20 . The high number of cases matching the criteria for SUNCT in this study is unexpected, as this type of headache is described as very uncommon.…”

Section: Discussionsupporting

confidence: 91%

Familial aggregation of cluster headache

Cruz

Lemos

Monteiro

2013

Arq. Neuro-Psiquiatr.

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Several studies suggest a strong familial aggregation for cluster headache (CH), but so far none of them have included subjects with probable cluster headache (PCH) in accordance with the International Classification of Headache Disorders. Objective: To identify cases of probable cluster headache and to assess the familial aggregation of cluster headache by including these subjects. Method: Thirty-six patients attending a headache consultation and diagnosed with trigeminal autonomic headaches were subjected to a questionnaire-based interview. A telephone interview was also applied to all the relatives who were pointed out as possibly affected as well as to some of the remaining relatives. Results: Twenty-four probands fulfilled the criteria for CH or PCH; they had 142 first-degree relatives, of whom five were found to have CH or PCH, including one case of CH sine headache. The risk for first-degree relatives was observed to be increased by 35-to 46-fold. Conclusion: Our results suggest a familial aggregation of cluster headache in the Portuguese population.Keywords: cluster headache, probable cluster headache, familial aggregation, cluster headache sine headache, first-degree relatives. REsumoDiversos artigos sugerem uma significativa agregação familiar da cefaleia em salvas (CH) embora nenhum tenha incluído indivíduos com provável cefaleia em salvas (PCH), segundo critérios da Classificação Internacional de Cefaleias (ICHD-II). Objetivo: Encontrar casos de provável cefaleia em salvas e avaliar a agregação familiar da cefaleia em salvas incluindo também esses indivíduos. Método: Foi aplicado um questionário por telefone a 36 doentes que frequentaram uma Consulta de Cefaleias com diagnóstico de cefaleia trigémino-autonómica. Todos os familiares de primeiro grau referidos como possivelmente afetados e alguns dos restantes foram entrevistados por telefone. Resultados: Em 24 doentes foi diagnosticada CH ou PCH e estes tinham 142 familiares de primeiro grau, cinco dos quais foram diagnosticados como CH ou PCH, incluindo um caso de CH sem cefaleias. O risco para familiares de primeiro grau foi 35-46 vezes superior ao da população geral. Conclusão: Nossos resultados sugerem a existência de uma agregação familiar da cefaleia em salvas na população portuguesa.Palavras-chave: cefaleia em salvas, provável cefaleia em salvas, agregação familiar, cefaleia em salvas sem cefaleia, familiares de primeiro grau.

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“…In some patients, the attacks occur at roughly the same time of the day every day, and in other clusters occur in the same period every year. 37 Permanent remission is seen, but after 15 years with the disease, 80% of patients still have attacks. However, about 10-15% of patients have chronic symptoms without remissions.…”

Section: Clinical Manifestationmentioning

confidence: 99%

The management of the patient with headache: from evidence to clinical practice

Gnerre¹,

Para

Antoniis

et al. 2015

Ital J Med

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EpidemiologyHeadaches are the most prevalent neurological disorders and are among the most frequent symptoms seen in general practice. The headache is about 30% of neurological specialist visits and continues to be a frequent cause of ED use, accounting for 2% of all visits. 4 50% of the general population have headaches during any given year, and more than 90% of them report a lifetime history of headache. 5 The only Italian epidemiological study (PACE study) 6 showed that 52% of men a and 43% of women interviewed suffered from headache in the last year. 7 Primary headache Migraine IntroductionMigraine is a common, debilitating headache disor- ABSTRACTHeadaches are the most prevalent neurological disorders and continue to be a frequent cause of Emergency Department use, accounting for 2% of all visits. Although it is a neurological disease it must be also a clinical competence of internist for its nature and frequency. The keys to effective management of these syndromes are differential diagnosis through history, physical examination, and diagnostic studies when necessary. This monograph highlights the importance of establishing whether headache is a secondary symptom of another disease process or a primary condition. The goal of headache management is for patients and healthcare professionals to work together to minimize pain and improve quality of life.

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Cluster headache

Cited by 495 publications

References 72 publications

Screening of Two ADH4 Variations in a Swedish Cluster Headache Case–Control Material

Screening of Two ADH4 Variations in a Swedish Cluster Headache Case–Control Material

Familial aggregation of cluster headache

The management of the patient with headache: from evidence to clinical practice

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