Cluster analysis reveals risk factors for repeated suicide attempts in a multi-ethnic Asian population

Choo, Carol C; Diederich, Joachim; Song, Insu; Ho, Roger

doi:10.1016/j.ajp.2013.10.001

Cited by 83 publications

(93 citation statements)

References 14 publications

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“…Chronic pain can independently contribute to the pathogenesis of depression, through elevation of inflammatory cytokines IL‐1β, IL‐6, and TNF‐α . Here, we review the prevalence and characteristics of depression, and its correlation to the levels of inflammatory cytokines and disease activity among different CTD (Tables and ).…”

Section: Depression In Connective Tissue Diseasesmentioning

confidence: 99%

“…The high prevalence of depression in primary SS has been established, and the estimated prevalence ranges from 8.33% to 75.56% (based on multiple diagnostic screening methods across various studies) . Depression in primary SS patients is associated with enhanced fatigue, increased levels of physical disability, reduced QOL, increased suicide risk, and increased health‐care costs . Depressed patients experience increased complications, and have poor long‐term outcomes and increased mortality .…”

Section: Depression In Connective Tissue Diseasesmentioning

confidence: 99%

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Cytokine secretion and the risk of depression development in patients with connective tissue diseases

Grygiel-Górniak

Limphaibool

Puszczewicz

2019

Psychiatry Clin Neurosci

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Research in the past two decades has revolutionized our understanding of depressive illnesses. Proinflammatory cytokines have become a point of interest in the interconnecting areas of neuropsychiatric and autoimmune diseases. The cytokine hypothesis of depression suggests that pro‐inflammatory cytokines play a primary role in the mediation of the pathophysiological characteristics of major depression, in which an inflammatory process may be induced by external and internal stressors, such as psychological and inflammatory diseases, respectively. The higher prevalence of depression, particularly in patients with chronic autoimmune connective tissue disorders (CTD), suggests that depression may present a dysfunctional adaptation of cytokine‐induced sickness, which could manifest in times of an exacerbated activation of the innate immune system. Inflammation is thought to contribute to the development of clinical depression through its ability to induce sickness behaviors corresponding to the neurovegetative features of depression, through the dysregulation of the hypothalamic–pituitary–adrenal axis, alterations in neurotransmitter synthesis and reuptake, and through its involvement in the neuroprogression pathways. This review explores the complex interrelationships in which inflammatory responses alter neuroendocrine and neuropsychological regulation contributing to depressive symptoms in CTD. The prevalence and characteristics of depression, and its correlation to the levels of inflammatory cytokines and disease activity among different CTD will be reviewed.

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Section: Depression In Connective Tissue Diseasesmentioning

confidence: 99%

Section: Depression In Connective Tissue Diseasesmentioning

confidence: 99%

Cytokine secretion and the risk of depression development in patients with connective tissue diseases

Grygiel-Górniak

Limphaibool

Puszczewicz

2019

Psychiatry Clin Neurosci

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“…Based on past evidence in both Western and Asian studies, analysis will be conducted on the following available variables, which are salient in literature with good clinical relevance. Risk factors include: living alone [27], unemployment [27–29], financial problem [30], physical illness [31], mental illness [29–30,32], alcohol/ drug use [6,33] interpersonal conflict [28–30], protective factors include: presence of dependents [34], emotional support [35], willingness to seek help [36–37], resolution of precipitants [38], religion [39], regret of the attempt [40], and positive future planning [41]. It is hypothesized that there will be ethnic differences in risk and protective factors for suicide attempts.…”

Section: Introductionmentioning

confidence: 99%

Does ethnicity matter in risk and protective factors for suicide attempts and suicide lethality?

et al. 2017

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This study explored ethnic differences in risk and protective factors for suicide attempts, for the major ethnic groups in Singapore, and ethnic differences in prediction of lethality. Three years of medical records related to suicide attempters (N = 666) who were admitted to the emergency department of a large teaching hospital in Singapore were subjected to analysis. Of the sample, 69.2% were female, 30.8% male; 63.8% Chinese, 15.8% Indian, and 15.0% Malay. Indians were over-represented in this sample, as compared with the ethnic distribution in the general population. Ages ranged from 10 to 85 years old (M = 29.7, SD = 16.1). Ethnic differences were found in risk and protective factors, and perceived lethality of suicide attempts. All available variables were subjected to regression analyses for Chinese, Indian and Malay attempters to arrive at parsimonious models for prediction of perceived lethality. The findings were discussed in regards to implications in assessment of suicide risk and primary prevention for the multiethnic society in Singapore.

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“…Usage of alcohol was associated with the risk of suicide (Choo et al, 2014) but this study did not explore the relationship between substance abuse and suicide in Europeans. Ethnicity was found to influence the method of suicide (Ho et al, 2016) but this study could not obtain information on the method of suicide in different countries.…”

Section: Discussionmentioning

confidence: 99%

Suicide rates in the European Union Countries. An analysis from a multivariate approach

Barroso¹,

Barragán-Medero²,

Pérez‐Jorge³

2018

GJHS

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Suicide is one of the most important causes of death in the European Union Countries (EU) and is considered as a phenomenon which can be explained from a psychological, biological and social point of view. Objectives: This research will analyze the phenomenon of suicide in the European Union from a sociological point of view, with the aim of creating a multivariate model which explains such phenomenon. Method: Taking into account those data offered by the European Statistics Office (EUROSTAT), this study will try to explain, through the multiple linear regression model, suicide rates in European countries from demographic variables (number of inhabitants, divorce rate, ratio of women), economic variables (Gross Domestic Product (GDP), general government gross debt), social variables (government expenditure on social protection, population at risk of poverty) or educational variables (public expenditure on education and population with secondary education). Conclusions: A model to explain suicide rates in different countries was developed. This model was made up of two variables (percentage of people with secondary education and ratio of women), which account for 50% of the suicide rate.

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Cluster analysis reveals risk factors for repeated suicide attempts in a multi-ethnic Asian population

Cited by 83 publications

References 14 publications

Cytokine secretion and the risk of depression development in patients with connective tissue diseases

Cytokine secretion and the risk of depression development in patients with connective tissue diseases

Does ethnicity matter in risk and protective factors for suicide attempts and suicide lethality?

Suicide rates in the European Union Countries. An analysis from a multivariate approach

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