Clozapine-induced extrinsic allergic alveolitis

Abstract

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Iatrogenic eosinophilic pleural effusion

“…No cases of pleural disease following treatment with olanzapine have been reported so far in the literature. However, several cases of pulmonary adverse events have been described following treatment with clozapine, including subacute diffuse interstitial pneumonitis and exudate pleural effusions, occasionally eosinophilic [20][21][22][23]. We have not found a study that could elucidate the immunological mechanisms of these reactions.…”

Myocarditis, pericarditis and cardiomyopathy in patients treated with clozapine

“…Benning (34) has reported a 45‐year‐old man who presented with fever, leucocytosis and eosinophilia 15 days after being started on clozapine (400 mg/day). Chest X‐ray revealed abnormalities suggestive of an acute inflammatory process.…”

Letters to the Editor

“…In addition to our case, there has been 1 other case report of multisystem organ failure (2). There have also been 24 case reports of new onset physical illness temporally associated with clozapine starts (3)(4)(5)(6)(7)(8)(9)(10)(11).…”

“…Until recently, our strategy was to admit most or all individuals in these high-risk groups in the hope ofpreventing a small number of tragedies (7). While it has been argued that this approach led to an unacceptably high level of falsepositives (8), risk reduction is not the only goal of admission. A stay in 392 hospital is often justified to treat the illness optimally and to remove the patient from the stressful situation that led to the original presentation.…”