Clot-Promoting and Platelet-Aggregating Effects of Fatty Acids

Free fatty acid-induced platelet aggregation: Studies with solubilized and nonsolubilized fatty acids

“…2 and 3), in agreement with previous work (7,8,10,18). To correlate the platelet responses to the many and varied aggregation inducing and inhibiting agents, a basic platelet reaction hypothesis has been proposed (23).…”

“…Thrombin, collagen, adenosine diphosphate (ADP), epinephrine, and long chain (>C14) unesterified fatty acids are compounds encountered in oioo that have been shown to initiate platelet aggregation (1)(2)(3)(4)(5)(6)(7)(8)(9)(10).…”

“…Numerous studies (6)(7)(8)(9)(10) have demonstrated hypercoagulability and platelet aggregation both in uiuo and in uitro in response to administered fatty acid concentrations within the normal physiological range of 300-1200 p M . Numerous studies (6)(7)(8)(9)(10) have demonstrated hypercoagulability and platelet aggregation both in uiuo and in uitro in response to administered fatty acid concentrations within the normal physiological range of 300-1200 p M .…”

“…Since the critical micellar temperature is > 3 7 O for most poorly soluble long chain fatty acids (19), a suspension state, rather than a micellar state, is anticipated. Inspection of data (7,8,10,18) correlating platelet aggregating activity with free fatty acid chain length leads to the generalization that aggregating activity is negligible below '214, with activity increasing markedly with chain lengths up to (220; i.e., the fatty acids least likely to form micelles exhibit the greatest platelet aggregating activity. This trend holds for both saturated and unsaturated fatty acids when the aggregation of washed platelet preparations in uitro is examined (9,10,20).…”

The Influence of Plasma Free Fatty Acids and Cholesterol on the Aggregation of Blood Platelets in Migraine Patients

“…To date, it is well established that stearic and palmitic acids can promote the aggregation of blood platelets. 31 The effect of oleate remains unclear. It is believed that it has little effect.…”