Free fatty acid-induced platelet aggregation: Studies with solubilized and nonsolubilized fatty acids

Zentner, Gaylen M.; Cardinal, John R.; Kim, S.W.

doi:10.1002/jps.2600700902

Cited by 2 publications

(1 citation statement)

References 27 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vasopressin, fatty acids and immune complexes: Unlike human platelets, porcine platelets did not respond to different forms of synthetic vasopressin (57). Aggregation response to free fatty acids increased with the fatty acid concentration and chain length (58). Precipitated immune complexes might initiate porcine platelet aggregation and serotonin secretion in a manner that was partially blocked by soluble immune complexes (59).…”

Section: Functional Studies In Vitromentioning

confidence: 99%

Porcine platelets in vitro and in vivo studies: Relevance to human thrombosis research

Søfteland

Framstad²,

Thorsen

et al. 1992

European J of Haematology

View full text Add to dashboard Cite

This review summarizes present knowledge on porcine platelets in vitro and recent studies on in vivo activation of platelets in the pig. There are certain differences compared to human platelets: Platelet aggregation and secretion cannot be achieved by epinephrine, and the arachidonate pathway seems poorly developed in porcine platelets. Genetic models for von Willebrand disease (vWD) and storage pool deficiency (SPD) have been developed in the pig. Several models for the study of in vivo platelet deposition and early thrombus formation have been developed. Platelet radio‐labeling techniques (with 111In) have been used extensively. We conclude that the pig seems to be a good choice for the investigation of in vivo platelet activation and deposition based on present knowledge of porcine platelets and on already established animal models.

show abstract

Section: Functional Studies In Vitromentioning

confidence: 99%