Clostridium Infection in Mother and Infant

Intra‐uterine infection due to Clostridium perfringens with delivery of a stillborn infant with hypoplastic left heart syndrome

“…In the majority of those cases chorioamnionitis was present. The clinical manifestations were the same as those seen in adults (3,5,6,7,9).…”

“…C. perfringens sepsis in the neonate is very rare. Septicemia has been related to surgery, invasive procedures, exchange transfusion, necrotizing enterocolitis and omphalitis (4,7,9,10). Several reports have focused on fulminant congenital sepsis at birth as well.…”

Bacterial Sepsis and Meningitis

“…Infections caused by Clostridium species can be localized, as in the case of omphalitis [232], cellulitis, and necrotizing fasciitis [233], or can manifest as sepsis or meningitis [234]. Disease in neonates has been related to Clostridium perfringens, Clostridium septicum, Clostridium sordellii, Clostridium butyricum, Clostridium tertium, and Clostridium paraputrificum [235].…”

“…Disease in neonates has been related to Clostridium perfringens, Clostridium septicum, Clostridium sordellii, Clostridium butyricum, Clostridium tertium, and Clostridium paraputrificum [235]. Chaney [234] reported a case of bacteremia caused by C. perfringens in a mother and neonate in which the neonate had classic features of adult clostridial sepsis, including active hemolysis, hyperbilirubinemia, and hemoglobinuria. Chaney [234] reported a case of bacteremia caused by C. perfringens in a mother and neonate in which the neonate had classic features of adult clostridial sepsis, including active hemolysis, hyperbilirubinemia, and hemoglobinuria.…”

“…Chaney [234] reported a case of bacteremia caused by C. perfringens in a mother and neonate in which the neonate had classic features of adult clostridial sepsis, including active hemolysis, hyperbilirubinemia, and hemoglobinuria. Clostridial sepsis has a high mortality rate [234]. Clostridial sepsis has a high mortality rate [234].…”