Clostridium difficile infection in pregnant and postpartum women in 2 hospitals and a review of literature

Meda, Manjula; Virgincar, N.; Gentry, V.; Walker, Amanda; MacDonald, Neil; Hooper, Michaela; Wells, S. M.; Anderson, Charlotte; Garner, David M.; Mumtaz, Shamma; Smith, Alyson

doi:10.1016/j.ajic.2018.06.001

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…A 25-week pregnant woman whose pregnancy was terminated early because of PMC due to C. difficile colitis and had to undergo emergent subtotal colectomy is presented here. Although publications emphasized that CDIs pose an increased risk in pregnant women, especially after cesarean section, diagnosis during pregnancy may increase morbidity and mortality of both mother and baby ( 4 , 6 ).…”

Section: Discussionmentioning

confidence: 99%

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A Case of Clostridioides difficile Infection of a Pregnant Woman Treated with Colectomy

Tekin

İrkören

Sucu

et al. 2022

Infect Dis Clin Microbiol

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Clostridioides difficile-associated pseudomembranous colitis (PMC) is a life-threatening inflammatory bowel disease. Here, we aimed to present a 40-year-old woman at 25 weeks of gestation whose pregnancy was terminated earlier than expected. Unfortunately, despite fidaxomicin and oral vancomycin, the patient’s diarrhea did not improve, and she had to undergo a subtotal colectomy. C. difficile infections developing in pregnant women can be catastrophic for both baby and maternal health. Also, antibiotic stewardship is crucial in the prevention of PMC. Therefore, unnecessary and prolonged use of antibiotics should be avoided. Keywords: Clostridioides difficile, pregnant, colectomy, colitis

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Section: Discussionmentioning

confidence: 99%

“…Although pregnant women are known as a low-risk group for PMC due to their young age and overall good health, PMC may cause life-threatening problems in pregnant women, and it may be a potential threat to both maternal and fetal health ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

A Case of Clostridioides difficile Infection of a Pregnant Woman Treated with Colectomy

Tekin

İrkören

Sucu

et al. 2022

Infect Dis Clin Microbiol

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“…Не варто забувати і про фізіологічну імуносупресію у таких жінок. Тож розвиток ПМК може виявитися катастрофічним для здоров'я матері та дитини [16,17]. Tekin S. та співавт.…”

Section: (116)2024 інфекційні хворобиunclassified

Pseudomembraneous Colitis. Is There a Danger for Pregnants?

Копча,

Шпікула

2024

ІХ

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Псевдомембранозний коліт (ПМК) – це захворювання, спричинене Clostridium difficile, яке переважно уражає нижні відділи травного каналу. Основними факторами ризику є прийом антибіотиків, похилий вік і тривала госпіталізація. Патогенез хвороби остаточно не вивчений. Найчастіше клінічна картина проявляється типовими симптомами – діареєю, болем у нижніх квадрантах живота, гарячкою. Для підтвердження діагнозу необхідні лабораторна ідентифікація токсину C. difficile у зразку калу та/або виявлення псевдомембран під час ендоскопії. На сьогодні доступне консервативне лікування, однак може виникнути багато ускладнень, а в найтяжчих випадках може бути необхідним хірургічне втручання. Сучасні технології ще не в змозі допомогти усім хворим, оскільки не рідкісні рефрактерні й рецидивні форми недуги. Особливо складною може бути інфекція C. difficile (CDI) у вагітних, оскільки в такому разі вона становить серйозну небезпеку для здоров’я матері й дитини.

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“…Contrary to other GI bacterial infections [20], women are more vulnerable than men to both primary CDI and CDI relapse [25][26][27][28][29][30][31][32]. More recently, CDI has been flagged as an emerging threat to pregnant and peripartum women [33][34][35][36]. Similarly, older was not certified by peer review) is the author/funder.…”

Section: Introductionmentioning

confidence: 99%

Effects of sexual dimorphism and estrous cycle onC. difficileinfections in rodent models

Phan,

Washington,

et al. 2023

Preprint

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Clostridioides difficile infection (CDI) is responsible for the majority of identifiable hospital-related antibiotic-associated diarrhea. Susceptibility to CDI and severity of disease varies depending on a variety of factors such as aggressive use of broad-spectrum antibiotics, age, and immune status. Epidemiological studies have consistently shown that female patients are more at risk for CDI than their male counterparts. In this study, we show that female mice developed more severe CDI than their male counterparts when challenged with spores from three different C. difficile strains. CDI sexual dimorphism was still apparent when animals were placed under diet conditions that exacerbated CDI severity. Unlike male mice, females undergo the estrous cycle. Thus, female mice were challenged with C. difficile spores when they were at the estrus, metestrus, diestrus, late diestrus/early proestrus, proestrus, or late proestrus/early estrus stages. Animals were scored for CDI sign severity while continuously monitoring their estrous cycle stages. The resulting data showed a striking spike in CDI severity when animals were in proestrus the day before sign scoring. In contrast, animals who were in estrus the day before signs scoring were protected from CDI. Prophylactic treatment of CDI also showed sexual dimorphism with females responding better to treatment than males. Interestingly, infection sexual dimorphism was reversed in hamsters, with male hamsters developing more severe CDI signs than females. In conclusion, we have shown that mice recreate many of the conditions of sexual dimorphism of human CDI.

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Clostridium difficile infection in pregnant and postpartum women in 2 hospitals and a review of literature

Cited by 6 publications

References 25 publications

A Case of Clostridioides difficile Infection of a Pregnant Woman Treated with Colectomy

A Case of Clostridioides difficile Infection of a Pregnant Woman Treated with Colectomy

Pseudomembraneous Colitis. Is There a Danger for Pregnants?

Effects of sexual dimorphism and estrous cycle onC. difficileinfections in rodent models

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