Clostridium difficile colitis: A marker for ischemic colitis?

Fiddian-Green, Richard G.

doi:10.1503/cmaj.1041677

Cited by 3 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism implicates a stepwise exacerbation secondary to dehydration and hypotension precipitated by severe diarrhea induced by CDI, which leads to either global or localized bowel ischemia. This contributes to a more pronounced systemic inflammatory response and subsequently, fulminant colitis [ 27 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Rare Clinical Association between Clostridioides difficile Infection and Ischemic Colitis: Case Report and Literature Review

et al. 2021

View full text Add to dashboard Cite

Background and Objectives: Gut microbiota plays an important role in the wellbeing of the host through different interactions between microflora constituents. In certain instances, Clostridioides difficile may pullulate, causing infection with associated colitis that may vary in terms of severity from mild disease to severe colitis, with increased associated mortality due to its complications. However, there are few literature data regarding the association between Clostridioides difficile and ischemic colitis. Case report: We report the case of a 30-year-old male patient, overweight, with impending dehydration, who presented with hematochezia and colicky abdominal pain, with positive fecal tests for the detection of Clostridioides difficile infection and endoscopic appearance suggesting ischemic colitis in the sigmoid and left colon, confirmed by computed tomography and histology. The patient was treated with oral Vancomycin, with resolution of symptoms, and was reevaluated through colonoscopy eight weeks after discharge, with endoscopic mucosal normalization and histological scarring process on biopsy samples. Conclusion: We report one of the few cases in the literature of ischemic colitis associated with Clostridioides difficile infection, with resolution of clinical, endoscopic, and histologic changes after specific treatment with oral Vancomycin suggesting a possible association between the two diseases. We also review the existing literature data regarding this comorbid association.

show abstract

Section: Discussionmentioning

confidence: 99%

Rare Clinical Association between Clostridioides difficile Infection and Ischemic Colitis: Case Report and Literature Review

et al. 2021

View full text Add to dashboard Cite

show abstract

Clinical Practice and Infrastructure Review of Fecal Microbiota Transplantation for Clostridium difficile Infection

Kelly

Tebas

2018

Chest

View full text Add to dashboard Cite

A substantial proportion of Clostridium difficile infection (CDI) cases recur after completion of antibiotic therapy, and antibiotic cure rates diminish with each recurrence of CDI. Fecal microbiota transplantation (FMT) is an effective therapy for recurrent FMT, which otherwise requires prolonged or indefinite antibiotic treatment. FMT is performed by introducing the fecal microbial community obtained from a healthy donor or pool of donors into the stomach, small intestine, or colon of a patient with CDI. Multiple clinical trials support the usefulness of FMT in treating recurrent CDI, and CDI treatment guidelines now include consideration of FMT at the third CDI recurrence. However, there remain challenges to incorporating FMT into clinical practice. First, methods of fecal bacterial community processing vary, as do methods of FMT administration. Second, the optimal dosing strategy and expected benefit of FMT for refractory CDI, particularly for severe and severe complicated cases, are uncertain. Third, the US Food and Drug Administration (FDA) considers FMT an investigational treatment. Fourth, insurance reimbursement for FMT usually falls short of FMT administration costs. In the setting of rising C difficile incidence and growing evidence for FMT efficacy, the demand for FMT has increased. However, uncertainty surrounding optimal FMT preparation and administration methods, FDA oversight, and insurance reimbursement presently limits the clinical practice of FMT.

show abstract

Chronic intestinal ischaemia and Hirschsprung's disease

Fiddian-Green

2006

Archives of Disease in Childhood

View full text Add to dashboard Cite

did not investigate the reasons for noncompliance. It is not possible that the guardians were too sick with their pulmonary tuberculosis or HIV (not mentioned in the study, but assumed to be endemic in the suburbs of South Africa) to bring their children regularly to the clinics. On the basis of anecdotal experience of non-compliance, we use dual therapy with rifampicin and isoniazid. As soon as any non-compliers are located, intensive supervised treatment or directly observed therapy is instigated.

show abstract

Clostridium difficile colitis: A marker for ischemic colitis?

Cited by 3 publications

References 4 publications

Rare Clinical Association between Clostridioides difficile Infection and Ischemic Colitis: Case Report and Literature Review

Rare Clinical Association between Clostridioides difficile Infection and Ischemic Colitis: Case Report and Literature Review

Clinical Practice and Infrastructure Review of Fecal Microbiota Transplantation for Clostridium difficile Infection

Chronic intestinal ischaemia and Hirschsprung's disease

Contact Info

Product

Resources

About