Closed loop administration of propofol based on a Smith predictor: a randomized controlled trial

Reboso, José Antonio; González-Cava, José M.; Leon, Ana M.; Méndez‐Pérez, Juan Albino

doi:10.23736/s0375-9393.18.13058-6

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…Effect assessment: The first step toward personalizing drug infusion is the availability of an index that correlates well with the variable of interest. For general anesthesia, different measures have been proposed to measure the unconscious level of the patient: 114,115 116 However, one of the current challenging issues is the proposal of a reliable index to assess analgesia level in patients. This is a muchcomplicated problem due to the complexity of the involved mechanisms and the disturbances affecting the process.…”

Section: Cancer Pathways and Personalized Therapymentioning

confidence: 99%

“…Effect assessment: The first step toward personalizing drug infusion is the availability of an index that correlates well with the variable of interest. For general anesthesia, different measures have been proposed to measure the unconscious level of the patient: 114 , 115 Bispectral index (Medtronic), Spectral Entropy (Datex-Ohmeda), Narcotrend index (Monitortechnik), Patient State Index (Masimo), or Auditory Evoked Potentials Index (Danmeter). For neuromuscular blockade monitoring, there are also reliable techniques, and most of them are based on Train-of-four stimulation.…”

Section: Clinical Applications (On the Horizon)mentioning

confidence: 99%

See 1 more Smart Citation

Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine

Comte

Baumbach

Benis

et al. 2020

Network and Systems Medicine

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Introduction: Network and systems medicine has rapidly evolved over the past decade, thanks to computational and integrative tools, which stem in part from systems biology. However, major challenges and hurdles are still present regarding validation and translation into clinical application and decision making for precision medicine. Methods: In this context, the Collaboration on Science and Technology Action on Open Multiscale Systems Medicine (OpenMultiMed) reviewed the available advanced technologies for multidimensional data generation and integration in an open-science approach as well as key clinical applications of network and systems medicine and the main issues and opportunities for the future. Results: The development of multi-omic approaches as well as new digital tools provides a unique opportunity to explore complex biological systems and networks at different scales. Moreover, the application of findable, applicable, interoperable, and reusable principles and the adoption of standards increases data availability and sharing for multiscale integration and interpretation. These innovations have led to the first clinical applications of network and systems medicine, particularly in the field of personalized therapy and drug dosing. Enlarging network and systems medicine application would now imply to increase patient engagement and health care providers as well as to educate the novel generations of medical doctors and biomedical researchers to

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Section: Cancer Pathways and Personalized Therapymentioning

confidence: 99%

“…Effect assessment: The first step toward personalizing drug infusion is the availability of an index that correlates well with the variable of interest. For general anesthesia, different measures have been proposed to measure the unconscious level of the patient: 114 , 115 Bispectral index (Medtronic), Spectral Entropy (Datex-Ohmeda), Narcotrend index (Monitortechnik), Patient State Index (Masimo), or Auditory Evoked Potentials Index (Danmeter). For neuromuscular blockade monitoring, there are also reliable techniques, and most of them are based on Train-of-four stimulation.…”

Section: Clinical Applications (On the Horizon)mentioning

confidence: 99%

Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine

Comte

Baumbach

Benis

et al. 2020

Network and Systems Medicine

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“…A successful field of research has been focused on the use of the BIS signal in closed-loop control applications. Many closed-loop strategies can be found in the literature [11,12].…”

Section: Bismentioning

confidence: 99%

Modelling the PSI response in general anesthesia

Pérez

Torres

et al. 2020

J Clin Monit Comput

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In anesthesia automation, one of the main important issues is the availability of a reliable measurement of the depth of consciousness level (hypnosis) of the patient. According to this value, the hypnotic drug dosage can be adequately calculated. One of the most studied hypnosis indexes is the bispectral index (BIS). In this article we analyzed an alternative called patient state index (PSI). The objectives of this study are, first, to validate the accuracy of the PSI describing the hypnosis level during the maintenance phase of general anesthesia, by comparing with the BIS and, second, to model the relationship between propofol infusion rate and PSI values, obtained from a SEDLine monitor. For this, real data from patients undergoing general anesthesia simultaneously monitored with both BIS and PSI signals was used. Results obtained are interesting for a correct interpretation of PSI signal in clinical practice.

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“…an elegant randomized trial by reboso et al investigated the feasibility of adding a predictor to a controller in a closed-loop system to reach the desired hypnotic effect of Propofol earlier. 6 the combined software showed better performance than the operator's adjustments, reducing the number of anesthetist interventions.…”

mentioning

confidence: 94%

A year in review in Minerva Anestesiologica 2019. Anesthesia, analgesia, and perioperative medicine

Cavaliere

Allegri²,

Apan

et al. 2020

Minerva Anestesiol

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Closed loop administration of propofol based on a Smith predictor: a randomized controlled trial

Cited by 11 publications

References 21 publications

Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine

Network and Systems Medicine: Position Paper of the European Collaboration on Science and Technology Action on Open Multiscale Systems Medicine

Modelling the PSI response in general anesthesia

A year in review in Minerva Anestesiologica 2019. Anesthesia, analgesia, and perioperative medicine

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