Closed head injury-related information processing deficits: An event-related potential analysis

Duncan, Connie C.; Kosmidis, Mary H.; Mirsky, Allan F.

doi:10.1016/j.ijpsycho.2005.05.011

Cited by 69 publications

(57 citation statements)

References 126 publications

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“…As previously noted (Duncan et al, 43 Sloubonov et al 84 ), ERPs may prove useful for identifying, targeting, and evaluating interventions in persons with atypical recovery rates. Further, the superior temporal specificity of ERPs relative to other neuroimaging measures and overt behavioral responses elicited from clinical testing may enable us to better understand which aspects of neurocognition are affected by concussion in a noninvasive and increasingly affordable manner.…”

Section: Discussionmentioning

confidence: 75%

The Persistent Influence of Concussive Injuries on Cognitive Control and Neuroelectric Function

Moore

Hillman

Broglio

2014

Journal of Athletic Training

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Context: Increasing attention is being paid to the deleterious effects of sport-related concussion on cognitive and brain health.Objective: To evaluate the influence of concussion incurred during early life on the cognitive control and neuroelectric function of young adults.Design: Cross-sectional study. Setting: Research laboratory.Patients or Other Participants: Forty young adults were separated into groups according to concussive history (0 or 1þ). Participants incurred all injuries during sport and recreation before the age of 18 years and were an average of 7.1 6 4.0 years from injury at the time of the study.Intervention(s): All participants completed a 3-stimulus oddball task, a numeric switch task, and a modified flanker task during which event-related potentials and behavioral measures were collected.Main Outcome Measure(s): Reaction time, response accuracy, and electroencephalographic activity.Results: Compared with control participants, the concussion group exhibited decreased P3 amplitude during target detection within the oddball task and during the heterogeneous condition of the switch task. The concussion group also displayed increased N2 amplitude during the heterogeneous version of the switch task. Concussion history was associated with response accuracy during the flanker task.Conclusions: People with a history of concussion may demonstrate persistent decrements in neurocognitive function, as evidenced by decreased response accuracy, deficits in the allocation of attentional resources, and increased stimulusresponse conflict during tasks requiring variable amounts of cognitive control. Neuroelectric measures of cognitive control may be uniquely sensitive to the persistent and selective decrements of concussion.Key Words: concussions, inhibition, mental flexibility, attention, P3, N2 Key PointsSeven years after concussion, participants displayed disrupted higher-order neurocognition in the form of chronically impaired attention, working memory, inhibition, and interference control. The observed deficits in attention and conflict monitoring were only evident when cognitive demands were increased. Subtle deficits may remain unrecognized with other types of testing.

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Section: Discussionmentioning

confidence: 75%

The Persistent Influence of Concussive Injuries on Cognitive Control and Neuroelectric Function

Moore

Hillman

Broglio

2014

Journal of Athletic Training

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“…It should be noted, however, that a number of investigations of brain injury have not reported significant attenuation of P300 amplitude. In a recent investigation (Duncan et al, 2005), it was shown that P300 is low in amplitude in head-injury survivors only when the task is sufficiently demanding (Fig. 5).…”

Section: Traumatic Brain Injurymentioning

confidence: 88%

“…The most frequently reported effect of traumatic brain injury on ERPs is a reduction in the amplitude of auditory P300 (for a review, see Duncan et al, 2005). Early auditory processing deficits (see section on MMN) may affect perceptual ability and thereby indirectly affect auditory P300.…”

Section: Traumatic Brain Injurymentioning

confidence: 99%

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Duncan

Barry

Connolly

et al. 2009

Clinical Neurophysiology

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995

876

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“…Most studies report attenuation of P3b amplitude (e.g. Campbell et al 1986Campbell et al , 1990Ford and Khalil 1996;Segalowitz et al 1997Segalowitz et al , 2001Solbakk et al 1999Solbakk et al , 2000Bernstein 2002;Duncan et al 2005;Dupuis et al 2000;Gosselin et al 2006;de Beaumont et al 2007;Lavoie et al 2004). A reduction in P3b amplitude in TBI patients suggests a corresponding reduction in attentional resources allocated to updating working memory traces as compared with healthy controls (Duncan et al 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Campbell et al 1986Campbell et al , 1990Ford and Khalil 1996;Segalowitz et al 1997Segalowitz et al , 2001Solbakk et al 1999Solbakk et al , 2000Bernstein 2002;Duncan et al 2005;Dupuis et al 2000;Gosselin et al 2006;de Beaumont et al 2007;Lavoie et al 2004). A reduction in P3b amplitude in TBI patients suggests a corresponding reduction in attentional resources allocated to updating working memory traces as compared with healthy controls (Duncan et al 2005). Only a small proportion of existing TBI ERP studies reported abnormalities in N2 or an earlier-peaking P3a ERP thought to more directly reflect attentional-orienting (Curry 1980;Clark et al 1992;Ford and Khalil 1996;Solbakk et al 1999;Potter et al 2001;Duncan et al 2003Duncan et al , 2005, which strongly suggests inquiry should focus on any abnormalities of P3b-related (i.e., target-detection) brain activity.…”

Section: Introductionmentioning

confidence: 99%

Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

Witt

Lovejoy

Pearlson

et al. 2010

Brain Imaging and Behavior

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Up to one-third of patients with mild traumatic brain injury (TBI) demonstrate persistent cognitive deficits in the 'executive' function domain. Mild TBI patients have shown prefrontal cortex activity deficits during the performance of executive tasks requiring active information maintenance and manipulation. However, it is unclear whether these deficits are related to the executive processes themselves, or to the degree of mental effort. To determine whether prefrontal deficits also would be found during less effortful forms of executive ability, fMRI images were obtained on 31 mild TBI patients and 31 control participants during three-stimulus auditory oddball task performance. Although patients and controls had similar topographical patterns of brain activity, region-of-interest analysis revealed significantly decreased activity in right dorsolateral prefrontal cortex for mild TBI patients during target stimulus detection. Between-group analyses found evidence for potential compensatory brain activity during target detection and default-mode network dysfunction only during the detection of novel stimuli.

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Closed head injury-related information processing deficits: An event-related potential analysis

Cited by 69 publications

References 126 publications

The Persistent Influence of Concussive Injuries on Cognitive Control and Neuroelectric Function

The Persistent Influence of Concussive Injuries on Cognitive Control and Neuroelectric Function

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task

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