Clonostachysins A and B, New Antidinoflagellate Cyclic Peptides from a Marine‐Derived Fungus

Adachi, Kyoko; Kanoh, Kaneo; Wisespongp, Puntip; Nishijima, Miyuki; Shizuri, Yoshikazu

doi:10.1002/chin.200527190

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Linear Oligopeptides1

Nitrogen-containing Metabolites and Their Biological Acti1

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2020

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“…Clonostachys rogersoniana Anti-dinoflagellate activity [10] Clonostachysin B (8) Clonostachys rogersoniana Anti-dinoflagellate activity [10] Cyclo-(Gly-D-Leu-D-allo-Ile -L-Val-L-Val-D-Trp-β-Ala)…”

Section: Linear Oligopeptidesmentioning

confidence: 99%

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Metabolites from Clonostachys Fungi and Their Biological Activities

Han

Zhang

et al. 2020

JoF

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Clonostachys (teleomorph: Bionectria) fungi are well known to produce a variety of secondary metabolites with various biological activities to show their pharmaceutical and agrochemical applications. Up to now, at least 229 secondary metabolites, mainly including 84 nitrogen-containing metabolites, 85 polyketides, 40 terpenoids, and 20 other metabolites, have been reported. Many of these compounds exhibit biological activities, such as cytotoxic, antimicrobial, antileishmanial, antimalarial activities. This mini-review aims to summarize the diversity of the secondary metabolites as well as their occurrences in Clonostachys fungi and biological activities.

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Section: Linear Oligopeptidesmentioning

confidence: 99%

“…Clonostachysins A ( 7 ) and B ( 8 ) were two cyclic nonapeptides isolated from Clonostachys rogersoniana . They exhibited a selectively inhibitory effect on a dinoflagellate Prorocentrum micans at 30 μM but had no effect on other microalgae and bacteria, even at 100 μM [ 10 ].…”

Section: Nitrogen-containing Metabolites and Their Biological Actimentioning

confidence: 99%