Cloning, sequence analysis and chromosome localization of a <i>Drosophila</i> muscarinic acetylcholine receptor

Onai, Takeshi; FitzGerald, Michael G.; Arakawa, Shingo; Gocayne, Jeannine D.; Urquhart, Deborah A.; Hall, Linda M.; Fraser, Claire M.; McCombie, W. Richard; Venter, J. Craig

doi:10.1016/0014-5793(89)81095-6

Cited by 73 publications

(44 citation statements)

References 30 publications

(8 reference statements)

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“…Successful cloning of the Drosophila mAChR gene (Onai et al, 1989;Shapiro et al, 1989) enabled generation of the highly specific antiDrosophila mAChR antibody (Blake et al, 1993). We and others (Harrison et al, 1995) have used the antibody to characterize other insect's mAChRs, and we have reported the presence of mAChR on the PTTH-producing neurosecretory cells in Bombyx mori (Aizono et al, 1997a).…”

Section: Discussionmentioning

confidence: 99%

The release of an insect neuropeptide hormone, bombyxin, is regulated by muscarinic transmission in the brain-corpus cardiacum-corpus allatum complex of the silkworm, Bombyx mori (Lepidoptera: Bomby cidae).

Shirai

Jiang

Yoshioka

et al. 2001

Appl. Entomol. Zool.

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Immunoreactivities against anti-bombyxin and anti-muscarinic acetylcholine receptor on sequential sections of the pupal brain of Bombyx mori showed that bombyxin-producing neurosecretory cells expressed the muscarinic acetylcholine receptor. Carbachol at 100 mM induced isolated bombyxin-producing neurosecretory cells to depolarize in the range of 5 to 20 mV and the carbachol-induced depolarization was blocked with 1 mM atropine (muscarinic acetylcholine antagonist). These results suggested that a direct transmission to regulate release of bombyxin occurs on the bombyxin neurosecretory cells. In fact, the release of bombyxin from the brain-corpus cardiacum-corpus allatum complex was induced with carbachol and inhibited with atropine, indicating that the release of bombyxin is, at least partially, regulated by muscarinic transmission.

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Section: Discussionmentioning

confidence: 99%

The release of an insect neuropeptide hormone, bombyxin, is regulated by muscarinic transmission in the brain-corpus cardiacum-corpus allatum complex of the silkworm, Bombyx mori (Lepidoptera: Bomby cidae).

Shirai

Jiang

Yoshioka

et al. 2001

Appl. Entomol. Zool.

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“…The neurotransmitter acetylcholine signals via distinct ionotropic (nicotinic) and metabotropic (muscarinic) receptors in both vertebrates and invertebrates, including insects (23,24). In mammals, substantial evidence indicates a role for forebrain cholinergic mechanisms in learning and memory (25); in humans, loss of cholinergic function contributes to the loss of cognitive function seen in patients with Alzheimer's disease (26) and is a target for therapeutic intervention (27).…”

mentioning

confidence: 99%

Stimulation of muscarinic receptors mimics experience-dependent plasticity in the honey bee brain

Ismail

Robinson

Fahrbach

2005

Proc. Natl. Acad. Sci. U.S.A.

103

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Honey bees begin life working in the hive. At Ϸ3 weeks of age, they shift to visiting flowers to forage for pollen and nectar. Foraging is a complex task associated with enlargement of the mushroom bodies, a brain region important in insects for certain forms of learning and memory. We report here that foraging bees had a larger volume of mushroom body neuropil than did agematched bees confined to the hive. This result indicates that direct experience of the world outside the hive causes mushroom body neuropil growth in bees. We also show that oral treatment of caged bees with pilocarpine, a muscarinic agonist, induced an increase in the volume of the neuropil similar to that seen after a week of foraging experience. Effects of pilocarpine were blocked by scopolamine, a muscarinic antagonist. Our results suggest that signaling in cholinergic pathways couples experience to structural brain plasticity.acetylcholine ͉ Apis mellifera ͉ foraging ͉ mushroom body

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“…dGqa-3 Is Not Highly Expressed in Antennal Lobes. Muscarinic acetylcholine receptors are G protein-coupled receptors in animals, including Drosophila (44,45). The Drosophila receptors stimulate production of InsP3 when expressed and activated in Y1 adrenocarcinoma cells (44).…”

mentioning

confidence: 99%

Identification of a Drosophila G protein alpha subunit (dGq alpha-3) expressed in chemosensory cells and central neurons.

Talluri

Bhatt

Smith

1995

Proc. Natl. Acad. Sci. U.S.A.

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Cloning, sequence analysis and chromosome localization of a Drosophila muscarinic acetylcholine receptor

Cited by 73 publications

References 30 publications

The release of an insect neuropeptide hormone, bombyxin, is regulated by muscarinic transmission in the brain-corpus cardiacum-corpus allatum complex of the silkworm, Bombyx mori (Lepidoptera: Bomby cidae).

The release of an insect neuropeptide hormone, bombyxin, is regulated by muscarinic transmission in the brain-corpus cardiacum-corpus allatum complex of the silkworm, Bombyx mori (Lepidoptera: Bomby cidae).

Stimulation of muscarinic receptors mimics experience-dependent plasticity in the honey bee brain

Identification of a Drosophila G protein alpha subunit (dGq alpha-3) expressed in chemosensory cells and central neurons.

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