2000
DOI: 10.1016/s0014-2999(00)00171-0
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Cloning of rabbit α1b-adrenoceptor and pharmacological comparison of α1a-, α1b- and α1d-adrenoceptors in rabbit

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Cited by 28 publications
(36 citation statements)
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“…The drug showing the highest affinity among tested drugs was NAN-190; its subnanomolar affinity is equal to that of a representative a1-adrenoceptor antagonist, prazosin (pKi = 9 -10) (4,25,26). Furthermore, the binding affinity of NAN-190 for a 1-adrenoceptor was not different from that (pKi = 9.2) reported for 5-HT receptors (27), indicating that this drug is an antagonist of not only the 5-HT receptor but also the a1-adrenoceptor.…”
Section: Discussionmentioning
confidence: 99%
“…The drug showing the highest affinity among tested drugs was NAN-190; its subnanomolar affinity is equal to that of a representative a1-adrenoceptor antagonist, prazosin (pKi = 9 -10) (4,25,26). Furthermore, the binding affinity of NAN-190 for a 1-adrenoceptor was not different from that (pKi = 9.2) reported for 5-HT receptors (27), indicating that this drug is an antagonist of not only the 5-HT receptor but also the a1-adrenoceptor.…”
Section: Discussionmentioning
confidence: 99%
“…Our inability to detect the role of the a 1D -receptor may be explainable by the fact that no one has yet succeeded in demonstrating any a 1D -binding in the brain of either the rat (Yang et al, 1997), mouse (Yang et al, 1998), or rabbit (Piao et al, 2000) using the above antagonists as displacing agents. Therefore the a 1D -receptor responsible for behavioral activation must have some unique property such as a potential location in the peripheral nervous system which in some way communicates with the CNS.…”
Section: Role Of a 1 -Adrenoceptors In Behavioral Activitymentioning
confidence: 99%
“…However, direct binding studies showed that BMY 7378 inhibits 3 H-prazosin binding in the rabbit aorta with low affinity, presumably by binding to α 1A -and α 1B -adrenergic receptors. Moreover, relative level of expression of α 1D -adrenergic receptor mRNA in rabbit aorta is approximately 50 × lower than that of the α 1A -adrenergic receptor mRNA (Satoh et al 1998;Piao et al 2000). Negligible α 1D -adrenergic receptor function in aortic tonus regulation seems to be typical of rabbits, because administration of BMY 7378 blocked the α 1D -adrenergic receptor in the aorta of rats, leading to its dilatation (Goetz et al 1995).…”
Section: Discussionmentioning
confidence: 92%