1991
DOI: 10.1016/0888-7543(91)90107-p
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Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY

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Cited by 92 publications
(42 citation statements)
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“…Although this genetic fragment contains a number of genes, the most interesting candidate in the development of GCT is TSPY (Testis Specific Protein on the Y chromosome) (Arnemann et al, 1991). It is a multi-copy gene (Manz et al, 1993), expressed in spermatogonia, CIS and GB (Hildenbrand et al, 1999, Kersemaekers et al, 2005, Ng et al, 2008, Schnieders et al, 1996 It is shown to regulate cell cycle progression, by interacting with cyclin B 1 (Oram et al, 2006).…”
Section: Unique Characteristics Of Testis Specific Protein On the Y Cmentioning
confidence: 99%
“…Although this genetic fragment contains a number of genes, the most interesting candidate in the development of GCT is TSPY (Testis Specific Protein on the Y chromosome) (Arnemann et al, 1991). It is a multi-copy gene (Manz et al, 1993), expressed in spermatogonia, CIS and GB (Hildenbrand et al, 1999, Kersemaekers et al, 2005, Ng et al, 2008, Schnieders et al, 1996 It is shown to regulate cell cycle progression, by interacting with cyclin B 1 (Oram et al, 2006).…”
Section: Unique Characteristics Of Testis Specific Protein On the Y Cmentioning
confidence: 99%
“…51,52 A number of candidate genes are located in this chromosomal fragment, including TSPY, which stands for testis-specific protein on the Y chromosome. 37,[53][54][55][56] This multicopy gene [57][58][59] is expressed in germ cells. 53 More interesting is the finding that it is present in large amounts in CIS/ITGCNU and gonadoblastoma cells 37 (see Figure 2A); the mechanism for this is unclear so far.…”
Section: The Role Of Oct3/4 and The Y Chromosome In Type-ii Gctsmentioning
confidence: 99%
“…Geographical and ethnic variations with respect to various Y chromosomal genes are well known (Santos et al 2000). Some authors have reported a divergence of up to 10% in human TSPY (Arnemann et al 1991;Manz et al 1993). Schnieders et al (1996) had also reported the diversity of human TSPY at the transcript level with at least nine different splice variants.…”
Section: Tspy Genementioning
confidence: 99%
“…This gene family has 20-40 gene copies that vary from individual to individual (Dechend et al 2000). Its prototype coding sequence is 924 bp and a sequence divergence of 10% has been reported in human TSPY sequences (Arnemann et al 1991;Manz et al 1993). The function of TSPY sequences is to integrate TSPY protein into spermatogenesis (Vogel et al 1997) and it is involved in the proliferation of germ cells (Schnieders et al 1996).…”
Section: Introductionmentioning
confidence: 99%