Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene

Kasahara, Masanori; Gutknecht, Jutta; Brew, Keith; Spurr, Nigel K.; Goodfellow, Peter N.

doi:10.1016/0888-7543(89)90019-0

Cited by 152 publications

(113 citation statements)

References 29 publications

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“…Similar observations have also been made in other nematode species, such as C. elegans, T. vitrinus, O. dentatum and B. malayi where respectively 11, two, three and five male-enriched ASPs were found (Reinke et al, 2004;Nisbet and Gasser, 2004;Li et al, 2005;Cottee et al, 2006). This could also explain the homology with TPX, AEG1, CRISP-1 and CRISP-2, proteins which are involved in sperm maturation and fertilisation (Kasahara et al, 1989;Krätzsch-mar et al, 1996). However, not all members of the SCP/ Tpx-1/Ag5/PR-1/Sc7 family seem to have a reproductive function.…”

Section: Discussionsupporting

confidence: 66%

“…Members of this family contain the Pfam-domain PF00188 and include sperm coating proteins (SCP), acidic epididymal glycoproteins (AEG), testis specific proteins (TPX) and cysteine rich secreted proteins (CRISP). Most of these mammalian proteins are localised in the testis or epididymis and are thought to play a role in sperm maturation and sperm-oocyte interaction (Kasahara et al, 1989;Eberspaecher et al, 1995;Krätzschmar et al, 1996). Also, some toxins of insects (Ag5 and Ag3) (Lu et al, 1993), defence-related proteins of plants (Dixon et al, 1991) and some proteins of fungi and yeasts are members of this family.…”

Section: Introductionmentioning

confidence: 99%

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Gender-enriched transcription of activation associated secreted proteins in Ostertagia ostertagi

Visser

Zeveren

Meyvis

et al. 2008

International Journal for Parasitology

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Activation associated secreted proteins (ASP) are members of a nematode-specific protein family belonging to the SCP/Tpx-1/Ag5/ PR-1/Sc7 family. Three different types of molecules have been identified in this family: two-domain ASPs and single-domain ASPs showing homology to either the C-terminal or N-terminal domain of the two-domain ASP. The function of these proteins is still unclear, but a role in transition to parasitism and a role as allergen are often suggested. Here we report that the abomasal cattle parasite Ostertagia ostertagi produces at least 15 ASPs, including two-domain and C-and N-type single-domain ASPs. Ten of these are highly transcribed in the L4 stage, whereas others are highly enriched in adult male worms. The latter was especially the case for the N-type single-domain ASPs Oo-ASP1 and Oo-ASP2 and also for Oo-ASP3, which is homologous with the Haemonchus contortus and Ancylostoma caninum Ctype single-domain ASPs. Immunohistochemistry showed that Oo-ASP3 was localised in the oesophagus. Oo-ASP1 and Oo-ASP2 on the other hand were localised in the reproductive tract of both male and female worms, suggesting a role in reproduction or in the development of the reproductive tract. Ó

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Gender-enriched transcription of activation associated secreted proteins in Ostertagia ostertagi

Visser

Zeveren

Meyvis

et al. 2008

International Journal for Parasitology

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“…Many of these genes encode proteins specifically involved in the control of the meiotic cell cycle, such as cyclin A1 (Table 2) (Liu et al, 1998), cdk4-inhibitors p18 and p19 (Table 2) (Zindy et al, 2001), A-myb (Table 2) (Toscani et al, 1997), Nek2 (Table 9) (Di Agostino et al, 2002), but in many cases their expression reflects meiotic accumulation of transcripts destined to be translated later during spermiogenesis, such as testis-specific lactate dehydrogenase (Table 7) (Li et al, 1998), testis-specific poly(A) polymerase b (Table 8) Kashiwabara et al, 2002), calmegin (Table 9) (Ikawa et al, 1997), preproacrosin (Table 5) (Kremling et al, 1991), fertilin b (Table 5) (Cho et al, 1998), Trf2 (Table 3) (Martianov et al, 2001), MSJ-1 (Table 5) (Berruti and Martegani, 2001), Tpx1 (Table 5) (Kasahara et al, 1989), Tekt1 (Table 5) (Larsson et al, 2000), Tesp1 (Table 5) (Kohno et al, 1998) and so on. It is noteworthy that the spermatocyte-specific expression of a large number of genes encoding enzymes is involved in glycolysis and gluconeogenesis, beside that of Pgk2, encoding a well known meiotic isoform of phosphoglycerate kinase (Boer et al, 1987) (Table 7).…”

Section: Resultsmentioning

confidence: 99%

Analysis of the gene expression profile of mouse male meiotic germ cells

Rossi

Dolci

Sette

et al. 2004

Gene Expression Patterns

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Wide genome analysis of difference in gene expression between spermatogonial populations from 7-day-old mice and pachytene spermatocytes from 18-day-old mice was performed using Affymetrix gene chips representing , 12,500 mouse known genes or EST sequences, spanning approximately 1/3rd of the mouse genome. To delineate differences in the profile of gene expression between mitotic and meiotic stages of male germ cell differentiation, expressed genes were grouped in functional clusters. The analysis confirmed the previously described pre-meiotic or meiotic expression for several genes, in particular for those involved in the regulation of the mitotic and meiotic cell cycle, and for those whose transcripts are accumulated during the meiotic stages to be translated later in post-meiotic stages. Differential expression of several additional genes was discovered. In few cases (pro-apoptotic factors Bak, Bad and Bax), data were in conflict with the previously published stage-dependent expression of genes already known to be expressed in male germ cells. Northern blot analysis of selected genes confirmed the results obtained with the microarray chips. Six of these were novel genes specifically expressed in pachytene spermatocytes: a chromatin remodeling factor (chrac1/YCL1), a homeobox gene (hmx1), a novel G-coupled receptor for an unknown ligand (Gpr19), a glycoprotein of the intestinal epithelium (mucin 3), a novel RAS activator (Ranbp9), and the A630056B21Rik gene (predicted to encode a novel zinc finger protein). These studies will help to delineate the global patterns of gene expression characterizing male germ cell differentiation for a better understanding of regulation of spermatogenesis in mammals. q

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“…As evidenced by Northern blotting, Crisp2 is most abundantly expressed in the testis (Kasahara et al, 1989;Kratzschmar et al, 1996;O'Bryan et al, 1998). Crisp2 is not regulated by androgens and its mRNA is first expressed in pachytene spermatocytes (Haendler et al, 1997;O'Bryan et al, 1998).…”

Section: Introductionmentioning

confidence: 98%

Cysteine‐rich secretory proteins are not exclusively expressed in the male reproductive tract

Reddy¹,

Gibbs²,

Merriner³

et al. 2008

Developmental Dynamics

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The Cysteine-RIch Secretory Proteins (CRISPs) are abundantly produced in the male reproductive tract of mammals and within the venom of reptiles and have been shown to regulate ion channel activity. CRISPs, along with the Antigen-5 proteins and the Pathogenesis related-1 (Pr-1) proteins, form the CAP superfamily of proteins. Analyses of EST expression databases are increasingly suggesting that mammalian CRISPs are expressed more widely than in the reproductive tract. We, therefore, conducted a reverse transcription PCR expression profile and immunohistochemical analyses of 16 mouse tissues to define the sites of production of each of the four murine CRISPs. These data showed that each of the CRISPs have distinct and sometimes overlapping expression profiles, typically associated with the male and female reproductive tract, the secretory epithelia of exocrine glands, and immune tissues including the spleen and thymus. These investigations raise the potential for a role for CRISPs in general mammalian physiology. Developmental Dynamics 237:3313-3323, 2008.

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Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene

Cited by 152 publications

References 29 publications

Gender-enriched transcription of activation associated secreted proteins in Ostertagia ostertagi

Gender-enriched transcription of activation associated secreted proteins in Ostertagia ostertagi

Analysis of the gene expression profile of mouse male meiotic germ cells

Cysteine‐rich secretory proteins are not exclusively expressed in the male reproductive tract

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