Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34

Gow, Deborah J.; Garceau, Valérie; Kapétanovic, Ronan; Sester, David P.; Fici, Gregory J.; Shelly, John A.; Wilson, Thomas L.; Hume, David

doi:10.1016/j.cyto.2012.08.008

Cited by 42 publications

(52 citation statements)

References 58 publications

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“…The presence of feline CSF-1R in Ba/F3 cells (Ba/F3fCSF-1R) permitted proliferation in response to rhCSF-1 and removed the dependence of these cells for IL-3. Western blot analysis of these cells demonstrated detectable expression of feline CSF-1R at a similar level to porcine CSF-1R expressed in Ba/F3 cells [2] (Fig. 3).…”

Section: Resultsmentioning

confidence: 65%

“…2C and D). As noted previously in an analysis of pig CSF-1R [2], it is difficult to predict from these changes whether the cat receptor will bind CSF-1 or IL-34 from other species, and the results may inform both therapeutic applications and structure–function predictions.…”

Section: Resultsmentioning

confidence: 97%

“…The MTT bioassay for assessing the response of transfected Ba/F3 cells to CSF-1 has been previously described and optimised [2]. Both the parent Ba/F3 and Ba/F3 cells expressing feline CSF-1R survived and proliferated in IL-3.…”

Section: Resultsmentioning

confidence: 99%

“…Conversely, mouse CSF-1 bioactivity is restricted to non-primate species [2,7,14–18]. IL-34 has even more restricted species cross-reactivity; with the human and mouse ligands much less active on the other species, although both were active on the pig CSF-1R [2]. CSF-1 has been widely-used to drive proliferation and differentiation of mature macrophages from bone marrow or blood monocyte progenitors in multiple species.…”

Section: Introductionmentioning

confidence: 99%

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Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34)

et al. 2013

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Section: Resultsmentioning

confidence: 65%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34)

et al. 2013

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“…Intriguingly, the X. laevis IL-34-derived macrophages possess elevated arginase-1 gene expression and yet also exhibit potent respiratory burst responses, typical of mammalian M1 macrophages. It is notable that IL-34 is found across all vertebrates (Garceau et al, 2010; Gow et al, 2012; Gow et al, 2013; Wang et al, 2013). In fact, this cytokine may even predate CSF-1, considering the presence of IL-34 and absence of CSF-1 in the elasmobranch genome (Venkatesh et al, 2014).…”

Section: Monopoiesis In Anuramentioning

confidence: 99%

Amphibian macrophage development and antiviral defenses

Grayfer

Robert

2016

Developmental & Comparative Immunology

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Macrophage lineage cells represent the cornerstone of vertebrate physiology and immune defenses. In turn, comparative studies using non-mammalian animal models have revealed that evolutionarily distinct species have adopted diverse molecular and physiological strategies for controlling macrophage development and functions. Notably, amphibian species present a rich array of physiological and environmental adaptations, not to mention the peculiarity of metamorphosis from larval to adult stages of development, involving drastic transformation and differentiation of multiple new tissues. Thus it is not surprising that different amphibian species and their respective tadpole and adult stages have adopted unique hematopoietic strategies. Accordingly and in order to establish a more comprehensive view of these processes, here we review the hematopoietic and monopoietic strategies observed across amphibians, describe the present understanding of the molecular mechanisms driving amphibian, an in particular Xenopus laevis macrophage development and functional polarization, and discuss the roles of macrophage-lineage cells during ranavirus infections.

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Functional evolution of the colony-stimulating factor 1 receptor (CSF1R) and its ligands in birds

Hume

Gutowska-Ding

García‐Morales

et al. 2019

Journal of Leukocyte Biology

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Macrophage colony-stimulating factor (CSF1 or M-CSF) and interleukin 34 (IL34) are secreted cytokines that control macrophage survival and differentiation. Both act through the CSF1 receptor (CSF1R), a type III transmembrane receptor tyrosine kinase. The functions of CSF1R and both ligands are conserved in birds. We have analyzed protein-coding sequence divergence among avian species. The intracellular tyrosine kinase domain of CSF1R was highly conserved in bird species as in mammals but the extracellular domain of avian CSF1R was more divergent in birds with multiple positively selected amino acids. Based upon crystal structures of the mammalian CSF1/IL34 receptor-ligand interfaces and structure-based alignments, we identified amino acids involved in avian receptor-ligand interactions. The contact amino acids in both CSF1 and CSF1R diverged among avian species. Ligand-binding domain swaps between chicken and zebra finch CSF1 confirmed the function of variants that confer species specificity on the interaction of CSF1 with CSF1R. Based upon genomic sequence analysis, we identified prevalent amino acid changes in the extracellular domain of CSF1R even within the chicken species that distinguished commercial broilers and layers and tropically adapted breeds. The rapid evolution in the extracellular domain of avian CSF1R suggests that at least in birds this ligand-receptor interaction is subjected to pathogen selection. We discuss this finding in the context of expression of CSF1R in antigensampling and antigen-presenting cells.

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Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34

Cited by 42 publications

References 58 publications

Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34)

Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34)

Amphibian macrophage development and antiviral defenses

Functional evolution of the colony-stimulating factor 1 receptor (CSF1R) and its ligands in birds

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