Clonal expansion of multiple pulmonary leiomyomatous hamartoma: 12‐year follow‐up

Sugawara, Michio; Kato, Noriko; Endo, Masatoshi; Oizumi, Hiroyuki; Motoyama, Teiichi

doi:10.1111/j.1440-1827.2009.02453.x

Cited by 3 publications

(1 citation statement)

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“…[4] The MPLH is a special pulmonic lesion, and the individual lesions of which are composed of a mixture of smooth muscle and glandular elements. [5] The pathogenesis of MPLH is not clear, it is not associated with specific pathological conditions of the lung, some investigators have reported that uterine leiomyoma can be found in many cases of MPLH and suggested that MPLH is not a real hamartoma but represents metastasizing uterine leiomyoma. [6,7] However, there is still controversy whether MPLH represents the metastasizing uterine leiomyoma, as MPLH could not be distinguished pathologically from metastasizing uterine leiomyoma.…”

Section: Discussionmentioning

confidence: 99%

An unusual case report of multiple pulmonary leiomyomatous hamartoma

Cheng

Zhang

2019

Medicine

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Rationale: Multiple pulmonary leiomyomatous hamartoma (MPLH) is an extremely rare benign disease that mostly occurs in women of reproductive age. Patient concerns: A 32-year-old female patient recently diagnosed with multiple bilateral pulmonary nodules. She has the symptoms of dry cough, chest tightness, dyspnea on exertion. Chest X-ray identified multiple bilateral pulmonary nodules in the lung, and the diameter of the largest nodule was about 3.1 cm. Diagnoses: Pathology confirmed the diagnosis of MPLH based on morphology and immunohistochemical staining. Interventions: The patient presented with multiple well-defined nodular shadows in chest computed tomography (CT), atypical image and symptoms were detected. Positron emission tomography/CT scan showed mild fluorine-18 fluorodeoxyglucose uptake in the lesions and no abnormal foci in any other parts of her body. She subsequently underwent a video-assisted thoracoscopic surgery with wedge resection of the biggest one of the nodules. Then the patient given symptomatic treatment, without hormone, no further treatment was prescribed. Outcomes: The patient is in the good general condition and without obvious pulmonary symptoms after the follow-up of 1 year, chest CT scan showed no significant changes in the sizes and locations of her bilateral pulmonary nodules. Lessons: Due to its rare presentation, the primary MPLH may be undiagnosed. Awareness of main morphologic and immunohistochemical features of MPLH is critical for the recognition of this uncommon disease.

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Section: Discussionmentioning

confidence: 99%

An unusual case report of multiple pulmonary leiomyomatous hamartoma

Cheng

Zhang

2019

Medicine

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Development of the lungs; perinatal and developmental lung disease

Corrin

2011

Pathology of the Lungs

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Unusual cystic hamartomatous lung lesion with clinical manifestation of subpleural bullae in a woman of reproductive age: A case report

Yorita

Ayabe

Chosa

et al. 2015

Pathology International

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Pulmonary hamartoma is a common benign lung disorder, and most cases show solid nodules. Here, we documented the clinicopathological features of a growing, bulla-like, multilocular hamartomatous lung lesion in a woman of reproductive age. To the best of our knowledge, this disorder has not been reported in the literature to date. An asymptomatic 29-year-old Japanese woman with no significant past medical history was referred to our institution for surgical treatment of a bullous lesion in the right upper lobe because the pulmonary lesion had enlarged to multilocular cysts, including a giant bulla, within 1 year, leading to compression of the right lung. The bullous lesion, which was projected from the apex of the lung via a narrow stalk, showed nonemphysematous, multiloculated tissue. The wall mimicked a bronchiolar structure with ciliated, nonatypical epithelium and layers of nonatypical spindle cells that were positive for smooth muscle markers and sex steroid hormone receptors. No cartilage was included in the lesion. We believe that this may be a novel form of hamartoma. This disorder may be included in a differential diagnosis of subpleural bullous diseases in women of reproductive age.

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Clonal expansion of multiple pulmonary leiomyomatous hamartoma: 12‐year follow‐up

Cited by 3 publications

References 9 publications

An unusual case report of multiple pulmonary leiomyomatous hamartoma

An unusual case report of multiple pulmonary leiomyomatous hamartoma

Development of the lungs; perinatal and developmental lung disease

Unusual cystic hamartomatous lung lesion with clinical manifestation of subpleural bullae in a woman of reproductive age: A case report

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