Clonal eosinophilic disorders and the hypereosinophilic syndrome

Brito‐Babapulle, Finella

doi:10.1016/s0268-960x(97)90008-4

Cited by 70 publications

(67 citation statements)

References 183 publications

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“…Sufficient rehydration was done, Ofloxacin continued and oral prednisolone was advised considering a patient of polymyositis. His PBF report revealed Leucoerythroblastic blood picture with thrombocytopenia (Total count was 30x10 9 At CMH Saidpur, after admission and subsequently also, the deceased had persistent hypoalbuminaemia.…”

Section: Case Reportmentioning

confidence: 99%

Myeloproliferative Neoplasm with Prominent Eosinophilia

Giti

Bhuiyan

Hossain

et al. 2014

J. Bangladesh Coll. Phys.

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The patient, a young soldier aged 36 years having past history of malaria, was admitted in CMH Dhaka on 17 August 2011 as a transferred case from CMH Saidpur and died on 22 August 2011. The deceased was admitted in CMH Saidpur on 05 August 2011 with high fever for 05 days along with generalized joint and muscle pain. In spite of all available treatment the patient was deteriorating and he was then transferred to CMH Dhaka. At that time the patient was febrile, dehydrated and toxic with lymphadenopathy, extremely tender joints and muscles. The patient rapidly developed acute kidney failure and gradually developed features of DIC. His bone marrow examination revealed dyserythropoiesis with predominantly eosinophilic granulopoiesis, suggestive of myeloproliferative neoplasm with prominent eosinophilia. The patient was treated with injectable antibiotics, antimalarial and oral prednisolone with all intensive care facilities. Ultimately all attempts were proved unsuccessful and he died on 22 August 2011 at 1700 hrs. On autopsy the deceased had intra atrial thrombus and possibly that was the immediate cause of death. A haematological malignancy, myeloproliferative neoplasm with prominent eosinophilia, can very well produce such a fatal condition. DOI: http://dx.doi.org/10.3329/jbcps.v31i3.20985 J Bangladesh Coll Phys Surg 2013; 31: 162-167

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Section: Case Reportmentioning

confidence: 99%

Myeloproliferative Neoplasm with Prominent Eosinophilia

Giti

Bhuiyan

Hossain

et al. 2014

J. Bangladesh Coll. Phys.

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“…The diagnosis of CEL was based on a blood sample and bone marrow aspirate and biopsy analysis using conventional criteria. 4 The BCR-ABL transcript was negative by the conventional method of molecular analysis. 5 The bone marrow cells were cultured for obtaining karyotype according to a conventional method.…”

mentioning

confidence: 98%

Translocation t(1;16) in Chronic Eosinophilic Leukaemia

Lourenço¹,

Rueda²,

Ortega³

et al. 2005

Rev. Bras. Hematol. Hemoter.

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“…Sua natureza ainda permanece desconhecida e a relação da SHI com leucemia eosinofílica crônica é controversa 1 . O diagnóstico é empírico e definido por hipereosinofilia persistente sem nenhuma etiologia justificável (parasitária, alér-gica ou outra) associada a comprometimento orgâ-nico [1][2][3][4] . A hipereosinofilia também ocorre nas desordens mieloproliferativas, nas leucemias eosinofílicas agudas e crônicas 2,4 .…”

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Neuropatia periférica e miosite na síndrome hipereosinofílica idiopática: relato de caso

Scola

Trentin

Fabiani

et al. 2004

Arq. Neuro-Psiquiatr.

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RESUMO -Descrevemos um caso de síndrome hipereosinofílica idiopática, com manifestações clínicas de neuropatia periférica e sinais de miosite inflamatória. Trata-se de mulher de 20 anos de idade, que apresentou dificuldade progressiva para caminhar com quedas freqüentes e edema de membros inferiores até o nível do joelho, associado a parestesias e cãibras. O exame neurológico revelou hipotonia, arreflexia e redução da força e sensibilidade nos membros inferiores. O exame parasitológico de fezes foi negativo e o hemograma mostrou 24 % de eosinófilos (1848/mm 3 ). Estudo eletrodiagnóstico mostrou comprometimento axonal sensitivomotor nos nervos dos membros inferiores. A biópsia muscular mostrou discreta reação inflamatória perivascular e intersticial. Tratada com prednisona a paciente apresentou remissão dos sintomas em dois meses.PALAVRAS-CHAVE: neuropatia periférica, miosite, síndrome hipereosinofílica idiopática. Peripheral neuropathy and myositis in idiopathic hypereosinophilic syndrome: case reportABSTRACT -We describe a case of idiopathic hypereosinophilic syndrome manifested by an axonal sensoriomotor polyneuropathy (ASMP) and signals of myositis. A 20 years old woman began with progressive gait impairment with drops and presented with subacute lower limb edema associated with paresthesis and cramps. She showed hypotonia in the lower limbs, absence of knee and ankle jerks, steppage gait, and decreased sensation on both legs. Examinations of stools were negative. Blood examination showed 7700 leukocytes with 24% (1848/mm 3 ) eosinophils. Electrodiagnostic studies showed axonal lesion in sensory and motor nerves. Muscle biopsy showed type 2 muscle fibers atrophy with discrete inflammatory cells, predominantly lymphocytic in perivascular and interstitial locations. She was treated with prednisone and all the symptoms subsided after two months.KEY WORDS: peripheral neuropathy, myositis, idiopathic hypereosinophilic syndrome.A síndrome hipereosinofílica idiopática (SHI) é desordem hematológica crônica rara, associada a lesão tecidual caracterizada pela produção persistente e excessiva de eosinófilos 1 . Sua natureza ainda permanece desconhecida e a relação da SHI com leucemia eosinofílica crônica é controversa 1 . O diagnóstico é empírico e definido por hipereosinofilia persistente sem nenhuma etiologia justificável (parasitária, alér-gica ou outra) associada a comprometimento orgâ-nico [1][2][3][4] . A hipereosinofilia também ocorre nas desordens mieloproliferativas, nas leucemias eosinofílicas agudas e crônicas 2,4 . Hipereosinofilia similar à da SHI ocorre também nas eosinofilias reativas 2 . O tratamento visa promover a supressão da hipereosinofilia, evitando-se deste modo o dano tecidual e a consequente morte do paciente. As drogas utilizadas pertencem à categoria dos corticoesteróides, imunossupressores ou imunomoduladores 1,3,4 . Com o propósito de contribuir com alguns dados de diagnóstico, tratamento e prognóstico relatamos um caso de SHI que se manifestou clinicamente como polineuropatia periférica e s...

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Clonal eosinophilic disorders and the hypereosinophilic syndrome

Cited by 70 publications

References 183 publications

Myeloproliferative Neoplasm with Prominent Eosinophilia

Myeloproliferative Neoplasm with Prominent Eosinophilia

Translocation t(1;16) in Chronic Eosinophilic Leukaemia

Neuropatia periférica e miosite na síndrome hipereosinofílica idiopática: relato de caso

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