Clonal anergy blocks the response to IL-4, as well as the production of IL-2, in dual-producing T helper cell clones.

Abstract

In this report we extend the in vitro clonal anergy model to examine the regulation of proliferation in T cells that secrete both IL-2 and IL-4. Newly cloned Ag-specific murine T cells are shown to depend on both IL-2 and IL-4 synthesis for maximal proliferation. Whereas IL-2 responsiveness is constitutive in these cells, IL-4 responsiveness develops only after Ag and APC stimulation. Remarkably, proliferation of these cells to Ag is sensitive to inhibition by clonal anergy, even though IL-4 synthesis remains inducible. Anergy in these cells is associated with an inability to respond to IL-4, in addition to the development of an IL-2 production defect. The results suggest that anergy induction may be capable of preventing the clonal expansion of autoreactive T cells producing both IL-2 and IL-4 in vivo.

The immunosuppression effects of deforolimus (ridaforolimus, AP23573) on allograft organ transplantation

“…Clonal anergy was deemed as mechanisms to balance B cell tolerance and immunity 36 . Meanwhile, it was one of the mechanisms that T helper cell induced immune tolerance 37 . The molecular surface marker of CD19 is present in pre‐B lymphocytes and immature B lymphocytes.…”