Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation

Brašić, James Robert; Barnett, Jacqueline Y.; Kaplan, Diana; Sheitman, Brian; Aisemberg, Patricia; Lafargue, R. Todd; Kowalik, Sharon; Clark, Aileen; Tsaltas, Margaret Owen; Young, J. Gerald

doi:10.1212/wnl.44.7.1309

Cited by 72 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positive reports noted improvements in repetitive behaviors, aggression, social engagement, language, adventitious movements, and adaptive behavior. [26][27][28] In the largest of the open studies (n = 35 adults), 13 participants experienced adverse effects, with 3 reporting seizures. 27 Two of these participants had a preexisting seizure disorder that had been stabilized on anticonvulsants, and 1 experienced a new onset tonic-clonic seizures.…”

Section: Serotonergic Agentsmentioning

confidence: 99%

Psychopharmacological Interventions in Autism Spectrum Disorder

Politte

Henry

McDougle

2014

Harvard Review of Psychiatry

View full text Add to dashboard Cite

After participating in this educational activity, the physician should be better able to1. Prescribe the appropriate psychotropic medication to treat symptoms of ASD.2. Identify the side effects of the psychotropic medications used to treat ASD.Autism spectrum disorders (ASDs) are characterized by core deficits in social communication and language, and restrictive and repetitive behaviors that cause significant functional impairment and distress for affected individuals and their caregivers. The increasing prevalence of ASD, most recently estimated as 1 in 88 children, presents an ever-increasing burden on families, schools, medical systems, and society at large. Individuals with ASD commonly present for treatment of associated emotional and behavioral disturbances that include anxiety, symptoms of ADHD, compulsions and other repetitive behaviors, mood lability, irritability, aggression, and sleep disturbance. Psychotropic medications are widely utilized in alleviating these symptoms, though rigorous clinical trials in ASD are lacking for most areas of impairment. Strong evidence from randomized, placebo-controlled trials supports the use of atypical antipsychotics, particularly risperidone and aripiprazole, for managing severe irritability and aggression in ASD. Serotonin reuptake inhibitors are commonly used to treat anxiety and compulsions, though reports of efficacy in the literature are mixed, and behavioral side effects in children are common. Minimal evidence supports the utility of anticonvulsants and traditional mood stabilizers in managing mood lability and aggression. Stimulant and nonstimulant ADHD medications can be effective for reducing hyperactivity, inattention, and impulsivity, though to a lesser degree than in ADHD populations without ASD and with greater risk of adverse effects. Psychopharmacological interventions in development for core symptoms of autism include those that target the glutamatergic and GABAergic neurotransmitter systems and the neuropeptide oxytocin. Further research is needed to establish evidence-based interventions in ASD populations.

show abstract

Section: Serotonergic Agentsmentioning

confidence: 99%

Psychopharmacological Interventions in Autism Spectrum Disorder

Politte

Henry

McDougle

2014

Harvard Review of Psychiatry

View full text Add to dashboard Cite

show abstract

“…Published open trial studies with the less selective medication clomipramine have shown inconsistent findings and some have indicated that younger children respond less well (Brasic et al, 1994). Significant improvements have been more consistently observed in open studies of the SSRIs (DeLong, Teague, & McSwain-Kamran, 1998;Steingard, Zimnitzky, DeMaso, Bauman, & Bucci, 1997), including improvements in both repetitive behavior in children with autistic disorders.…”

Section: Serotonin Reuptake Inhibitors (Antidepressants)mentioning

confidence: 99%

Handbook of Intellectual and Developmental Disabilities

Jacobson¹,

Mulick²,

Rojahn³

2007

Issues on Clinical Child Psychology

View full text Add to dashboard Cite

show abstract

“…Published open trial studies with the less selective medication clomipramine have shown inconsistent findings and some have indicated that younger children respond less well [Brasic et al, 1994;McDougle et al, 2000]. Significant improvements have been more consistently observed in open studies of the SSRIs [Steingard et al, 1997;DeLong et al, 1998], including improvements in both repetitive behavior and social-communication symptoms.…”

Section: Medication Intervention Studiesmentioning

confidence: 99%

Treating the core features of autism: Are we there yet?

Bodfish

2004

Ment. Retard. Dev. Disabil. Res. Rev.

View full text Add to dashboard Cite

A wide variety of nonestablished treatments have been proposed as "cures" for the core features of autism and are used frequently despite having largely escaped scientific scrutiny. In contrast, a growing body of empirical evidence supports the use of a few forms of theory-based and empirically validated treatment for some aspects of the core features of autism. These include behavioral/psychoeducational interventions and specific forms of medication treatment, which can produce significant improvements in communication, social interaction, and problem behaviors that both maintain over time and generalize across settings. While there is no doubt that treatment and educational services for persons with autism have improved over the past 6 decades, it also appears that significant issues remain with respect to (1) the routine application of validated treatments for the majority of cases with autism, (2) the resistance to even validated forms of treatment for a substantial minority of cases with autism, and (3) the extent to which validated treatments effectively treat the specific core features of autism that are most disabling for persons with autism and their families.

show abstract

Clomipramine ameliorates adventitious movements and compulsions in prepubertal boys with autistic disorder and severe mental retardation

Cited by 72 publications

References 0 publications

Psychopharmacological Interventions in Autism Spectrum Disorder

Psychopharmacological Interventions in Autism Spectrum Disorder

Handbook of Intellectual and Developmental Disabilities

Treating the core features of autism: Are we there yet?

Contact Info

Product

Resources

About