Clock mechanisms in zebrafish

Cahill, Gregory M.

doi:10.1007/s00441-002-0570-7

Cited by 256 publications

(190 citation statements)

References 51 publications

(63 reference statements)

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“…Moreover, cell-autonomous circadian oscillators are present throughout the peripheral tissues and organs of zebrafish. 53,54) Importantly, zebrafish peripheral clocks are directly light-responsive. 55) Thus, in zebrafish organs and tissues, an acute light pulse can be used to transactivate clock genes and thus entrain oscillations of clock gene expression to a new light-dark cycle.…”

Section: Zebrafish As a Model System For Circadian Clock Studymentioning

confidence: 99%

Section: Redox Signaling Is Involved In the Light Entrainment Of The mentioning

confidence: 99%

“…53) Seven zebrafish Cry genes (zCry1a, 1b, 2a, 2b, 3, 4 and Dash) have been cloned. 53,61) Investigation of the in vitro functions of these genes has shown that they fall into two groups: one group inhibits CLOCK:BMAL-mediated transcription (repressor type CRYs: zCRY1a, 1b, 2a and 2b), whereas the other group does not inhibit transcription (non-repressor type CRYs: zCRY3, 4 and Dash). 61,62) Despite its structural and functional similarities to the repressor type CRYs, zCry1a transcription is quite different from that of the other repressor type CRYs and is strictly light-dependent (Fig.…”

Section: Redox Signaling Is Involved In the Light Entrainment Of The mentioning

confidence: 99%

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A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

Uchida

Hirayama

Nishina

2010

Biological & Pharmaceutical Bulletin

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INTRODUCTIONFrom bacteria to humans, almost all organisms can adapt the timing of their physiology to the cyclic changes of their environment, thanks to a naturally-selected intrinsic timekeeping system called the circadian clock. 1) The circadian clock enhances the physiological efficiency and survival of an organism by organizing its behavior and body functions. 2,3) During the circadian day, the organism's physiology is given over to catabolic processes, whereas the anabolic functions of growth, repair and consolidation occur at night. To achieve this schedule in mammals, the circadian clock regulates a number of physiological functions, including sleep and wakefulness, food intake, body temperature, cardiovascular and renal activity, hormone production, hepatic metabolism and immune responses. 4,5) Accordingly, disruption of the circadian clock in humans has been linked to profound effects on health, including insomnia, stomach ailments, depression and cancer. 4,5) In most organisms, the molecular mechanisms underlying the establishment and maintenance of biological rhythms comprise interconnected transcription-translation feedback loops in which some clock factors repress their own transcription once they have attained critical levels. 2,3) These oscillators have the property of being endogenous and cellautonomous systems that maintain their rhythm in the absence of external time cues. 6) Both vertebrates and invertebrates have circadian oscillators scattered throughout their bodies. 7,8) In mammals, the circadian system is composed of both central and peripheral oscillators. 7) The mammalian central clock is located in the suprachiasmatic nucleus (SCN) within the anterior hypothalamus of the brain. 9) This central clock acts as a coordinator and provides time signals via both neural and humoral routes that entrain independent peripheral clocks. Dysfunction of the central clock does not inactivate the peripheral clocks but instead causes individual peripheral oscillators to become temporally uncoupled. [10][11][12] To guarantee that an organism's behavior remains tied to the rhythms of its environment, the circadian clock must be able to reset itself in response to environmental cues. 9,13,14) The main environmental stimulus for organisms is light, which is provided in day-night cycles. Mammals have no photoreceptors in peripheral tissues, 15) so that the effect of light on peripheral clocks is indirect. 13) For the mammalian clock, the SCN integrates photic cues from the retina and uses neural and humoral signals to transmit this information to peripheral clocks, synchronizing them. [16][17][18] This communication between the central and peripheral clocks results in the seamless regulation of fundamental physiological functions. 4,8) Interestingly, peripheral clocks can also respond directly to SCN-independent signals such as feeding and temperature change. 19,20) However, the physiological role of SCN-independent responses of peripheral clocks is not yet fully understood. A recent study has reported that ...

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Section: Zebrafish As a Model System For Circadian Clock Studymentioning

confidence: 99%

Section: Redox Signaling Is Involved In the Light Entrainment Of The mentioning

confidence: 99%

Section: Redox Signaling Is Involved In the Light Entrainment Of The mentioning

confidence: 99%

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A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

Uchida

Hirayama

Nishina

2010

Biological & Pharmaceutical Bulletin

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“…These properties have established the zebrafish as an excellent model system that is relevant to studies of human diseases (Grunwald and Eisen, 2002). Zebrafish have also become the focus of neurobehavioral studies since larvae display learning, memory, sleep, drug addiction, and behavior phenotypes that are quantifiable and related to those seen in man (Zhdanova et al, 2001;Cahill, 2002;Guo, 2004;Orger et al, 2004;Ninkovic et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Non-Associative Learning in Larval Zebrafish

Best¹,

Berghmans²,

Hunt³

et al. 2007

Neuropsychopharmacol

211

150

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Habituation, where a response is reduced when exposed to a continuous stimulus is one of the simplest forms of non-associative learning and has been shown in a number of organisms from sea slugs to rodents. However, very little has been reported in the zebrafish, a model that is gaining popularity for high-throughput compound screens. Furthermore, since most of the studies involving learning and memory in zebrafish have been conducted in adults, we sought to determine if zebrafish larvae could display non-associative learning and whether it could be modulated by compounds identified in previous rodent studies. We demonstrated that zebrafish larvae (7 days post fertilization) exhibit iterative reduction in a startle response to a series of acoustic stimuli. Furthermore, this reduction satisfied criteria for habituation: spontaneous recovery, more rapid reductions in startle to shorter intertrial intervals and dishabituation. We then investigated the pathways mediating this behavior using established compounds in learning and memory. Administration of rolipram (PDE4 inhibitor), donepezil (acetylcholinesterase inhibitor), and memantine (N-methyl-D-aspartic acid (NMDA) receptor antagonist) all increased the acoustic startle response and decreased habituation in the larvae, similar to previous rodent studies. Further studies demonstrated that NMDA blocked the memantine response and the effect of donepezil was blocked by mecamylamine but not atropine suggesting that the donepezil response was mediated by nicotinic rather than muscarinic receptors. Zebrafish larvae possess numerous advantages for medium to high-throughput screening; the model described herein therefore offers the potential to screen for additional compounds for further study on cognition function.

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“…Além disso, homólogos ao gene period têm sido descritos em outros grupos, incluindo outros insetos (Barr et al 2005;Mazzotta et al 2005;Mazzoni et al 2006;Regier et al 2008), plantas (McClung, 2006) e vertebrados (Cahill, 2002;Reppert & Weaver, 2002). Nesses táxons, o gene period também foi utilizado como marcador para inferências de hipóteses filogenéticas (Barr et al 2005;Regier et al 2008) e divergência populacional (Bauzer et al 2002).…”

Section: Periodunclassified

Filogenia do Complexo Drosophila Buzzatii (Grupo Repleta): Inferências de Análises Multilocus Mitocondriais e Nucleares.

Ferreira¹

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Filogenia do complexoOrientador: Prof a . Dr a . Maura Helena Manfrin RIBEIRÃO PRETO 2011Autorizo a reprodução total ou parcial deste trabalho para fins de estudo, desde que citada a fonte. Dedico à minha companheira Caroline, com amor. FICHA CATALOGRÁFICA AGRADECIMENTOSEm especial à Prof a . Dr a . Maura Helena Manfrin (FFCLRP/USP), por ter confiado em meu potencial e me orientado de forma tão prestativa e paciente. Obrigado por todos os ensinamentos, pela motivação e, principalmente, pela amizade.Ao Prof. Dr. Fábio de Melo Sene (FMRP/USP), por todos os ensinamentos, idéias, discussões e, principalmente, pelas histórias compartilhadas nos cafés do laboratório.Ao Prof. Dr. Reinaldo O. A. A. de Brito (UFSCar), pela ajuda com o alinhamento das sequências e sugestões.Ao Prof. Dr. Iderval da Silva Junior Sobrinho (UFSCar), pelas discussões sobre estatística e seleção.Aos professores da banca examinadora, pela disponibilidade em analisar este trabalho.Às amigas Carla Bruniera e Dr a . Érica Cristina de Carvalho, pela fundamental ajuda nas análises filogenéticas.Aos amigos do laboratório, Paulo Epifânio, Mateus Henrique, Luís Bizzo, Camila Kokudai, Cintia Graziela, Gislaine Rodrigues e Taís Lavagnini, por estarem sempre dispostos a me ajudar e por tornarem a convivência no laboratório tão agradável. Ao Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), pela bolsa de mestrado. À CAPES, FINEP, FAPESP, CNPq e USP que fornecem verbas para a manutenção do Laboratório de Genética Evolutiva.Ao Departamento de Genética da FMRP/USP, pela disponibilização de recursos.À toda a minha família, em especial aos meus pais, Manoel Ferreira Dionísio Jr.e Rosimeiry Ap. Fransak Davanso, ao meu padrasto, Carlos Roberto Davanso, e aos meus avós, Narciso Fransak, Olga Alves Fransak e Elza Peroni, por toda dedicação e por terem sempre me incentivado e investido em minha formação.À minha querida companheira Caroline dos Santos Rodrigues, pela paciência, carinho, apoio e dedicação. et al. 1996). Tal abordagem é essencial para o entendimento das relações filogenéticas, especialmente entre espécies de divergência recente, nas quais existe pouca divergência morfológica e genética, possibilitando a análise dos processos microevolutivos pelos quais a diversidade biológica é gerada em eventos de especiação (Machado & Hey, 2003). O complexo Drosophila buzzatiiO gênero Drosophila é dividido hierarquicamente em "subgêneros", "grupos", "subgrupos", "complexos" e "clusters" de espécies. Embora não reconhecida pelo Código Internacional de Nomenclatura Zoológica, essa classificação é amplamente utilizada em estudos envolvendo espécies desse gênero (Bächli, 2010 Marcadores molecularesAnálises usando múltiplas fontes de informação têm se multiplicado em estudos de evolução. Uma das razões para este fato é que quanto mais aprendemos sobre o processo evolutivo, torna-se evidente que diferentes conjuntos de dados não são equivalentes (Huelsenbeck et al. 1996;Avise, 2009 .1. Citocromo oxidase I e IIO DNA mitocondrial apresenta muitas carac...

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Clock mechanisms in zebrafish

Cited by 256 publications

References 51 publications

A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses

Non-Associative Learning in Larval Zebrafish

Filogenia do Complexo Drosophila Buzzatii (Grupo Repleta): Inferências de Análises Multilocus Mitocondriais e Nucleares.

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