Clinicoradiologic characteristics of patients with lung adenocarcinoma harboring EML4-ALK fusion oncogene

Fukui, Takayuki; Yatabe, Yasushi; Kobayashi, Yohnosuke; Tomizawa, Kenji; Ito, Simon; Hatooka, Shunzo; Matsuo, Keitaro; Mitsudomi, Tetsuya

doi:10.1016/j.lungcan.2012.03.013

Cited by 101 publications

(101 citation statements)

References 29 publications

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“…Tumors with ALK rearrangement were less seen to have brain metastasis. Our results were consistent with several previous studies (18,20,24,25).…”

Section: Discussionsupporting

confidence: 94%

“…Both of the groups were prone to be non-smokers, which was consistent with previous studies (20)(21)(22)(23). No statistically significant difference was found in tumor metastasis, but the tendencies were agree with Choi et al (18).…”

Section: Discussionsupporting

confidence: 92%

“…These results were consistent with previous studies in NSCLC (10,15,18). CEA is an important serum tumor marker; recent studies have found that patients with ALK rearrangement were seen more frequently to have normal serum CEA level in lung adenocarcinoma (19,20). However the study populations of these retrospective investigations were most with early clinical stage.…”

Section: Discussionsupporting

confidence: 91%

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Comparison of clinical and radiological characteristics between anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation in treatment naïve advanced lung adenocarcinoma

Miao

Zhu

et al. 2017

J. Thorac. Dis.

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Background: Gene analysis could not be performed in all patients, especially in advanced non-small cell lung cancer (NSCLC). We aimed to find some clinical futures and CT or FDG-PET characteristics, which could be combined to help distinguish anaplastic lymphoma kinase (ALK) rearrangement form epidermal growth factor receptor (EGFR) mutations in treatment naïve advanced lung adenocarcinoma of Chinese patients. Methods:We retrospectively reviewed clinical and radiological characteristics of 145 patients with treatment naïve advanced lung adenocarcinoma. The one-way ANOVA, the Mann-Whitney test, chi-square test and logistic regression were used for comparison between patients with ALK rearrangement and those with EGFR mutation.Results: Among 145 patients with advanced lung adenocarcinoma, only six patients had both ALK rearrangement and EGFR mutation, the sample size was too small to analysis. Univariate analysis revealed that patients with ALK rearrangement were younger (P=0.001) and with lower serum carcinoembryonic antigen (CEA) level (P=0.008) than those with EGFR mutation. More of tumors with ALK rearrangement were well defined (P=0.023) and have bubble lucency (P=0.026) compared with those with EGFR mutation (P=0.026). Lymphadenopathy was seen more frequently in patients with ALK rearrangement (P=0.167). Twenty-six patients received FDG-PET/CT, among this population, lesion standardized uptake values (SUV)>6.95 and lymph nodes SUV max >6.25 were more often seen in ALK rearrangement group (P=0.011, both).In multivariate analysis, patients younger than 50 years (RR =9.878, 95% CI: 2.318-42.090, P=0.002), with lower CEA level than 4.95 μg/L (RR =8.166, 95% CI: 1.085-31.983, P=0.003) and without brain metastasis (RR =7.304, 95% CI: 1.099-48.558, P=0.040) were more likely to be ALK rearrangement than EGFR mutation. Tumor diameter less than 36 mm were prone to be EGFR mutation (RR =0.078, 95% CI: 0.017-0.356, P=0.001).Conclusions: Treatment naïve advanced lung adenocarcinomas with ALK rearrangement were more likely to have younger age, lower serum CEA level, larger tumor volume, well defined tumor border, and non-brain metastasis than those with EGFR mutation. Bubble lucency and higher FDG uptake of lesion and lymph nodes may help distinguish ALK rearrangement from EGFR mutation in the absence of genetic analysis.

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“…Tumors with ALK rearrangement were less seen to have brain metastasis. Our results were consistent with several previous studies (18,20,24,25).…”

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Comparison of clinical and radiological characteristics between anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation in treatment naïve advanced lung adenocarcinoma

Miao

Zhu

et al. 2017

J. Thorac. Dis.

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“…Zhou et al (37) compared the radiologic characteristics of lung adenocarcinomas with presence or absence of ALK rearrangements and EGFR mutations. They demonstrated that the percentages of GGO volume and TDR were significantly lower in the ALK rearrangements group than the EGFR mutation group and the wild type group, which was consistent with the study by Fukui et al (49). In their analysis, the mean TDRs were significantly lower in the ALK rearrangement positive group (P=0.0006).…”

Section: Molecular Pathology and Ct Featuressupporting

confidence: 86%

Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Gao

Rizzo

et al. 2017

Transl. Lung Cancer Res.

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“…ALK gene rearrangements were screened with immunohistochemistry using sensitive ALK antibody (clone 5A4, Santa Cruz, Calif., USA) and the EnVision FLEX+ detection system (Dako, Copenhagen, Denmark). When positive or equivocal results were obtained with the immunohistochemistry, further confirmatory fluorescent in situ hybridization was carried out using an ALK break-apart probe (Vysis LSI ALK Dual Color, Break Apart Rearrangement Probe; Abbott Molecular, Abbott Park, Ill., USA) as previously described [32,33]. …”

Section: Methodsmentioning

confidence: 99%

Feasibility and Accuracy of Molecular Testing in Specimens Obtained with Small Biopsy Forceps: Comparison with the Results of Surgical Specimens

Oki

Yatabe²,

Sasaki³

et al. 2015

Respiration

Self Cite

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Background: During bronchoscopy, small biopsy forceps are increasingly used for the diagnosis of peripheral pulmonary lesions. However, it is unclear whether the formalin-fixed paraffin-embedded specimens sampled with the small biopsy forceps are suitable for the determination of genotypes which become indispensable for the management decision regarding patients with non-small cell lung cancer. Objectives: The aim of this study was to evaluate the feasibility and accuracy of molecular testing in the specimens obtained with 1.5-mm small biopsy forceps. Methods: We examined specimens in 91 patients, who were enrolled in our previous 3 studies on the usefulness of thin bronchoscopes and given a diagnosis of non-small cell lung cancer by bronchoscopy with the 1.5-mm biopsy forceps, and then underwent surgical resection. An experienced pathologist examined paraffin-embedded specimens obtained by bronchoscopic biopsy or surgical resection in a blind fashion on epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) rearrangements and KRAS mutations. Results: Twenty-five (27%), 2 (2%) and 5 (5%) patients had an EGFR mutation, ALK rearrangement and KRAS mutation, respectively, based on the results in surgical specimens. EGFR, ALK and KRAS testing with bronchoscopic specimens was feasible in 82 (90%), 86 (95%) and 83 (91%) patients, respectively. If molecular testing was feasible, the accuracy of EGFR, ALK and KRAS testing with bronchoscopic specimens for the results with surgical specimens was 98, 100 and 98%, respectively. Conclusion: The results of molecular testing in the formalin-fixed paraffin-embedded specimens obtained with the small forceps, in which the genotype could be evaluated, correlated well with those in surgically resected specimens.

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Clinicoradiologic characteristics of patients with lung adenocarcinoma harboring EML4-ALK fusion oncogene

Cited by 101 publications

References 29 publications

Comparison of clinical and radiological characteristics between anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation in treatment naïve advanced lung adenocarcinoma

Comparison of clinical and radiological characteristics between anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation in treatment naïve advanced lung adenocarcinoma

Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Feasibility and Accuracy of Molecular Testing in Specimens Obtained with Small Biopsy Forceps: Comparison with the Results of Surgical Specimens

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