Clinicopathology of sodium bicarbonate induced gout in broiler chicken model

Ali, Rayeesa; Kamil, Shayaib Ahmad; Amin, Umar; M, Mir; Shah, Ahmed Ijaz; Kashani, Bisma; Dar, Tawseef; Shah, Syed Aftab Hussain; Qureshi, Sabia

doi:10.5958/0973-970x.2018.00010.x

Cited by 1 publication

(9 citation statements)

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“…Raised levels of uric acid in the blood (hyperuricaemia), which may be due either to over production of uric acid or impaired destruction of uric acid because of deficient enzymes systems or to its decreased excretion, either due to impaired filtration or altered excretion in the tubules as may occur in drug therapy like aspirin, mercuric salts etc. (Ali and Sultana, 2012).…”

Section: Causesmentioning

confidence: 99%

“…The kidney performed its normal physiological functions only when calcium and phosphorus are maintained in a specific ratio of 2:1 that necessitates maintenance of different physiological mechanisms including secretions, excretions and resorption etc. An imbalance of these minerals in diet can result in renal failure and development of gout in chicken (Ali and sultana, 2012). Outbreak of gout attributed to disproportionate Ca: P ratio (3.5: 1) and 16.39% crude protein in the feed has been reported (Mir et al, 2005;Guo et al, 2005).…”

Section: Mineralsmentioning

confidence: 99%

“…Sodium bicarbonate can contribute to gout by making the urine more alkaline, which, with high levels of calcium, is an ideal medium for the formation of kidney stones. (Alice mitchell, 2015; Ali et al, 2018;Ejaz et al, 2005).…”

Section: Mineralsmentioning

confidence: 99%

“…infeCtiouS CauSeS Among the infectious causes, the viral pathogens like Avian Nephritis Virus (ANV), Nephropathic Infectious Bronchitis Virus (IBV) and Chicken Astrovirus (CAstV) ( Bulbule NR et al, 2013) are listed, but the IBV may lead to permanent kidney damage with high mortality (Singh et al, 2010). The most prevalent strain of IBV was Masachusette strain; its outbreaks caused visceral gout and nephrosis in commercial young broiler chicken and widely spread throughout the country in a short period, therefore caused huge economic losses (Gaba et al, 2010;Ali and sultana, 2012;Panigrahi, 2017). The disease, when vertically transmitted, affects the kidney of progeny leading to gout in young chickens (Alice mitchell, 2015).…”

Section: Mineralsmentioning

confidence: 99%

“…G out is a common metabolic disorder that results in abnormal accumulation of urates in domestic birds (Ali and Sultana, 2012). In case of gout, the blood levels of uric acid can be as high as 44 mg/100ml as compared to 5-7mg/100ml in a normal bird.…”

Section: Introductionmentioning

confidence: 99%

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Review - Gout In Chicken

Sandhyarani¹,

Madhuri²,

Ravikumar³

2021

AAVS

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|Chicken is more prone to gout due to uricotelic mechanism for excretion of nitrogenous waste and lack the enzyme uricase, which converts uric acid to less harmful substances. Uric acid itself is not toxic but precipitated crystals can cause severe mechanical damage to tissues like kidneys, heart, lungs, intestine (visceral gout) and also in the joints (articular gout). Gout is a multifactorial metaboic disease which involves infectious agents, nutritional factors and managemental prcatices. Infectious agents include Nephropathic Infectious Bronchitis Virus (IBV), Avian Nephritis Virus (ANV), Chicken Astrovirus (CAstV) and nutritional factors like high dietary calcium (>2%), high crude protein (> 30%), Hypovitaminosis A, Hypervitaminosis D3, dehydration, high sodium carbonate, Copper sulfate, mycotoxins in feed causes renal failure leads to gout. The managemental practices involves high brooding temperature thereby reducing the water intake and hence increasing chances of development of gout. In addition, products used on a routine basis and result into toxicity includes antibiotics, anticoccidials, manufactured chemicals, and pesticides can also induce gout in poultry. Clinical signs include decreased feed and water intake, lethargy, ruffled feathers, weight loss and abnormal droppings. Clinically, the body fluid reveals increase in TEC, TLC, Hb and PCV and decreased alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatases (ALP), serum total proteins, serum albumin and glutathione stimulating hormone (GSH). Grossly, chalky white deposits of urate crystals on the serosal surface of pericardium, liver, intestines, air sacs, kidneys and ureters. Microscopically, tissue sections show urate crystal deposition in parenchyma of the organs along with infiltration of inflammatory cells. Incorporation of low protein diets, jaggery mixed water, supplementation of B complex and electrolytes helps in the control of gout.

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Section: Causesmentioning

confidence: 99%

Section: Mineralsmentioning

confidence: 99%

Section: Mineralsmentioning

confidence: 99%

Section: Mineralsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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