Clinicopathological Study of Primary Intraosseous Squamous Cell Carcinoma of the Jaw and a Review of the Literature

Naruse, Tomofumi; Yanamoto, Souichi; Sakamoto, Yuki; Ikeda, Tohru; Yamada, Shin‐ichi; Umeda, Masahiro

doi:10.1016/j.joms.2016.05.006

Cited by 19 publications

(25 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results suggest that these two PIOC, NOS cases belong to different subcategories. However, its low incidence leads to difficulties in performing a systematic analysis that includes many cases of these odontogenic carcinomas, which can only be done with a review of the literature [20].…”

Section: Discussionmentioning

confidence: 99%

Genetic and histopathological analysis of a case of primary intraosseous carcinoma, NOS with features of both ameloblastic carcinoma and squamous cell carcinoma

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Primary intraosseous carcinoma (PIOC), NOS is an odontogenic carcinoma with unknown etiology. Its diagnosis may be used when central jaw carcinoma cannot be categorized as any other type of carcinoma. Further information on this extremely rare tumor is needed to improve our understanding and evaluate the classification of odontogenic carcinomas. Case presentation: We herein presented two patients with PIOC, NOS with different clinical and histopathological features and analyzed gene mutations in these patients using next-generation sequencing (NGS). The typical PIOC, NOS case had many histopathological similarities to oral squamous cell carcinoma (OSCC), including the missense point mutations of TP53 Glu285Val, KDR Gln472His, and APC Pro1433Leu, which are similar to those in other cancers; however, no mutations were detected in the other patient with an atypical presentation of PIOC, NOS, which was derived from a precursor cystic lesion with similarities to both ameloblastic carcinoma and OSCC. Conclusions: Genetic analysis suggested that these two PIOC, NOS cases have different features and can be subcategorized.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic and histopathological analysis of a case of primary intraosseous carcinoma, NOS with features of both ameloblastic carcinoma and squamous cell carcinoma

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is tempting in such cases to treat the patient by removing the offending tooth, incising and draining any associated abscess, and treating with antibiotics. However, clinicians should be very cautious of hastily removing a tooth associated with underlying malignancy without further workup, since doing so has been linked to poorer patient prognosis [9]. This was illustrated by Naruse et al [9] for which at least 3 patients underwent initial tooth extraction before being diagnosed with SCC 1 to 2 months later in the same anatomical location.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Mandibular Squamous Cell Carcinoma in Intimacy with an Impacted Wisdom Tooth

Cheung

Afif

Bullock

et al. 2019

Case Reports in Surgery

View full text Add to dashboard Cite

Squamous cell carcinoma is the most common head and neck malignancy. It can occur in the mandible or maxilla without a preexisting oral mucosal lesion. Often, the clinical and radiographic presentation of SCC directs the clinician to favour malignancy over other pathological conditions. However, SCC may also mimic an infectious condition and therefore can pose a diagnostic challenge even for the most experienced clinicians. Herein, we report a case of mandibular squamous cell carcinoma in a 53-year-old male who presented with symptoms of right facial swelling, trismus, pain, and right-sided lip paresthesia. The patient underwent a surgical removal of the presumed infected third molar of the right mandible, but histopathological analysis of the associated soft tissue unexpectedly yielded squamous cell carcinoma. Given the biopsy-proven diagnosis, the patient received a mandibular resection of the tumor followed by primary reconstruction with a fibular free flap. Patients presenting with symptoms mimicking odontogenic infections should receive vigilant attention by clinicians with regard to the disease history, clinical signs, radiographic evidence, and decision for histopathological analysis. This is especially true in the context of impacted dentition, where malignancy must be considered when formulating a differential diagnosis.

show abstract

“…PIOC also superficially resembles many other routine dental disorders, such as dental infection, periodontal and periapical disease, resulting in a high occurrence of early misdiagnosis. A clinicopathologic review documented that the majority of patients receive pre‐operative dental procedures prior to a definitive diagnosis of PIOC. Parameters established to guide diagnosis of PIOC include: (i) intraoral clinical exam does not reveal any mucosal tumours or mucosal lesions overlying the central bony mass, (ii) histologic examination notes epithelial lining transitioning into SCC, (iii) primary neoplasm at a distant site should be ruled out and (iv) physical and radiographic examination.…”

Section: Discussionmentioning

confidence: 99%

“…Extensive clinical, radiographic and histopathologic testing needs to be conducted for the prompt diagnosis of PIOC. Intraoral examination, screening panoramic radiography, CT scan, PET scan, MRI and histopathologic examination are all important. Visualization of some carcinomatous features can be seen via CT, providing information on the size, shape and location of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Primary intraosseous carcinoma, NOS in a 17‐year‐old male: case report and literature review

Cox

Shuren²,

Chirila

et al. 2019

Oral Surgery

View full text Add to dashboard Cite

Primary intraosseous carcinoma (PIOC), NOS is a rare malignancy occurring in the jaw bones. It may arise de novo, or more commonly develop from pre-existing lesions such as odontogenic cysts or tumours. In this manuscript, we describe a case of PIOC in the mandible of a 17year-old male. Complicating factors were a history of familial hemophagocytic lymphohistiocytosis and Griscelli syndrome. Management included surgical removal and planned adjuvant chemoradiation. The relevant literature is reviewed with respect to PIOC in a paediatric population.

show abstract

Clinicopathological Study of Primary Intraosseous Squamous Cell Carcinoma of the Jaw and a Review of the Literature

Abstract: 1Background: Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare

Cited by 19 publications

References 20 publications

Genetic and histopathological analysis of a case of primary intraosseous carcinoma, NOS with features of both ameloblastic carcinoma and squamous cell carcinoma

Genetic and histopathological analysis of a case of primary intraosseous carcinoma, NOS with features of both ameloblastic carcinoma and squamous cell carcinoma

An Unusual Case of Mandibular Squamous Cell Carcinoma in Intimacy with an Impacted Wisdom Tooth

Primary intraosseous carcinoma, NOS in a 17‐year‐old male: case report and literature review

Contact Info

Product

Resources

About