Clinicopathological study of migratory lung infiltrates.

Miyagawa, Yosuke; Nagata, Nobuhiko; Shigematsu, Nobuaki

doi:10.1136/thx.46.4.233

Cited by 49 publications

(25 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For more information regarding the clinical features of COP please refer to [15][16][17][18][19][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101]. Males and females are equally affected by COP, with mean age of onset ,50-60 yrs.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Radiation-primed organising pneumonia is thus quite similar to COP. Interestingly, this peculiar iatrogenic organising pneumonia provides some insight into the pathogenesis of Chlamydia pneumoniae [184,185] Coxiella burnetii [186,187] Legionella pneumophila [95,[188][189][190][191][192][193][194] Mycoplasma pneumoniae [95,189,[195][196][197] Nocardia asteroides [198,199] Pseudomonas aeruginosa [200] Serratia marcescens [201]; in lung transplant recipient [200] Staphylococcus aureus In lung transplant recipient [200] Streptococcus pneumoniae [5,6,202] Viruses Adenovirus [203] Cytomegalovirus [203,204] Herpes virus In lung transplant recipient [200] HIV [205][206][207][208][209][210]; in a pregnant patient using cocaine [205]; following highly active antiretroviral therapy introduction [211] Influenza virus [189,[212][213][214] Parainfluenza virus [215] Human herpes virus-7 …”

Section: Determined Causes Of Organising Pneumoniamentioning

confidence: 99%

See 1 more Smart Citation

Cryptogenic organising pneumonia

Jf¹

2006

European Respiratory Journal

477

466

View full text Add to dashboard Cite

Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific, this histopathological pattern, together with characteristic clinical and imaging features, defines cryptogenic organising pneumonia when no cause or peculiar underlying context is found. Rapid clinical and imaging improvement is obtained with corticosteroid treatment, but relapses are common after stopping treatment.

show abstract

Section: Clinical Featuresmentioning

confidence: 99%

Section: Determined Causes Of Organising Pneumoniamentioning

confidence: 99%

Cryptogenic organising pneumonia

Jf¹

2006

European Respiratory Journal

477

466

View full text Add to dashboard Cite

show abstract

“…It also appears that BAL and the presence of numerous eosinophils in the BAL fluid can establish the diagnosis, whether or not transbronchial biopsy is carried out as well [7]. Radiographically, the infiltrates may be transient and they tend to resolve and reappear in the same or a distinct location [8]. Peripheral blood eosinophilia is usually present and elevated serum IgE levels have been reported during the acute phase, which return to normal during remissions, with or without treatment, suggesting that eosinophilic pneumonia may be an IgE-mediated hypersensitivity pneumonitis [9].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic lung disease associated with Candida albicans allergy

Pacheco¹,

Cuevas²,

Carbelo³

et al. 1998

Eur Respir J

View full text Add to dashboard Cite

There are few references in the literature about the role of Candida albicans (CA) in eosinophilic lung disease. Asthma related to immunoglobulin (Ig)E-mediated allergy to CA [1] as well as allergic bronchopulmonary candidiasis has been described [2], but the implication of CA in chronic eosinophilic pneumonia has not been previously reported. In this paper we report on a patient in whom chronic eosinophilic pneumonia developed and levels of specific anti-CA IgE in the serum paralleled the clinical course of the disease. Case reportA 43 yr old female was admitted to the hospital reporting symptoms of an intermittent fever of 38°C, nocturnal sweat, chills, dyspnoea, dry cough and malaise, with a weight loss of 4-5 kg during the last 45 days. No improvement was observed despite several courses of amoxicillin and cephalosporin being given. These symptoms were reported by the family because she had had severe mental deficiency since 11 months of age, as a result of severe traumatic head injury. The physical examination revealed a respiratory frequency of 32 breaths·min -1 and crackles in both pulmonary bases. The blood count detected 2,400 eosinophils·mm -3 . The chest radiograph showed a patchy, nonsegmental infiltrate of peripheral distribution in the upper right lobe. This radiological pattern changed its localization at 48 h, inside the same lobe ( fig. 1). There was no previous history of asthma, ingestion of drugs or inhalation of fumes. Although bronchoscopy was indicated, transbronchial biopsy was not possible owing to a lack of collaboration. Bronchoalveolar lavage (BAL) showed a predominant fraction of 40% eosinophils in cytological analysis, with 57% macrophages and 3% lymphocytes. CA was the only fungus isolated from the BAL culture.The serum rheumatoid factor, anti-nuclear antibody, canti-neutrophil cytoplasmic antibody (ANCA) and p-ANCA were all negative. Negative skin-prick test responses were obtained to grass, weed and tree pollens, house dust mite and dog and cat dander. Four examinations of stools for ova of parasites at different times were negative. Total serum IgE and antifungus specific IgE were determined by a fluoroenzyme immunoassay (CAP System; Pharmacia Diagnostics, Uppsala, Sweden) and the results expressed in kU·L -1 . Specific anti-fungus IgG was assessed by an enzyme-linked immunosorbent assay (ELISA) method as described previously [3] and the results were expressed in optical densities (OD). A value at least twice over the negative control (0.6 OD) was considered positive. Serum immunological assays were carried out for seven fungi: Mucor spp., Penicillium spp., Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum, Trichophyton and CA, and also for Echinococcus granulosus and Toxocara canis. A positive result was only detected for anti-CA IgE: 32.7 kU·L -1 (normal <0.35 kU·L -1 ). The ELISA deter-mination of anti-CA IgG showed a titre of 2.3 OD. Total serum IgE was 1,430 kU·L -1 . Leukocyte histamine release test using peripheral blood was performed as described previou...

show abstract

“…[1][2][3] In the endemic area, parasitic infections are also considered. ▸ When lung infiltrations with GGO are rapidly worsening, physicians should be aware of the possibility of carcinomatous lymphangiosis in addition to the diseases identified above.…”

Section: Learning Pointsmentioning

confidence: 99%