Clinicopathological study of leiomyomas in hysterectomy specimens

Abstract

Background: Leiomyomas are benign tumors of smooth muscle cells commonly encountered in women of reproductive age group. Aim of this study was to conduct a histopathological study of leiomyomas in hysterectomy specimens and to correlate them with clinical findings.Methods: A prospective study was done on 130 hysterectomy specimens clinically diagnosed as leiomyoma. The specimens were subjected to histopathological examination.Results: In this study, the most common age group was 31-50 years (87.69%). Most common complaint was menorrhagia (51.54%). In endometrium, the most common histopathological diagnosis was proliferative phase (46.15%) followed by endometrial hyperplasia (19.23%). The most common secondary change was hyalinization and the most common site was intramural (62.9%).Conclusions: Hysterectomy is a commonly performed procedure in the management of uterine leiomyomas. The ultimate diagnosis and prognosis depends on the histopathological examination; therefore, every operated specimen must be subjected to histopathology.

Leiomyomas in Hysterectomy Specimens: A Clinicohistopathological Study

“…Leiomyomas are mostly asymptomatic but when symptomatic, most common clinical manifestation is menorrhagia due to increased vascularity, endometrial surface and altered uterine contractility which was chief complaint in 45.97% cases in our study and studies of Geethamala et al 12 49.36%, Kaur et al 13 51.54%, Abraham and Saldanha 10 40%. It is followed by pain abdomen possibly due to degenerative changes in leiomyomas, seen in 19.23% cases in our study, similar to Lahori et al 11 In our study leiomyomas in uterus were singly seen in 52.01% uteri and multiple fibroids were seen in 48.99% uteri.…”

“…Dual pathology of adenomyosis and leiomyomas were noted in 31.07% of patients in present study similar to studies by Geethamala et al (29.1%), 12 Gowri et al (29%) 18 and Kaur et al (27.69%). 13 However studies by Lahori et al (19.23%) 11 and Kulkarni et al (16%) 15 show lower incidence. Coexistence of these lesions may be due to unopposed estrogenic stimulation.…”

“…Number 10 Lahori et al, 11 Geethamala et al 12 and Kaur et al 13 The specimen obtained was most commonly uterocervix with bilateral adnexa (66.23%), while only uterocervix was obtained in 22.45% cases and uterocervix with one sided adnexa was excised in 11.32% cases. Comparable data was seen in study of Geethamala et al 12 with abdominal hysterectomies in 80.24% and vaginal hysterectomies in 19.76%.…”