Clinicopathological studies of experimentally induced Nickel Chloride in Wistar rats (<i>Rattus norvegicus</i>)

Lambade, P.S.; Joshi, D. V.; Patel, B. J.; Patel, J.G.; Raval, S.H.; Patel, Jilpa

doi:10.5958/0973-970x.2015.00009.7

Cited by 4 publications

(8 citation statements)

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“…Adult Wistar rats were administered nickel chloride by gavage daily for 28 days at 0, 5.25, 10.5 and 21 mg/kg bw (assuming that the doses are expressed as nickel chloride, the corresponding doses of nickel are 1.0, 4.8 and 9.5 mg/kg bw per day) (Lambade et al., 2015; see also Appendix B.1). According to the authors, testes of mid‐ and high‐dosed rats showed severe testicular degeneration, which was described by the authors as ‘emptying of the seminiferous tubules’.…”

Section: Assessmentmentioning

confidence: 99%

“…Adult Wistar rats were administered nickel chloride by gavage daily for 28 days at 0, 5.25, 10.5 or 21 mg/kg bw (assuming that the doses are expressed as nickel chloride, the corresponding doses of nickel are 1.0, 4.8 and 9.5 mg/kg bw per day) (Lambade et al., 2015). The control group was administered deionised water.…”

Section: Appendix B – Hazard Identification and Characterisationmentioning

confidence: 99%

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Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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Section: Assessmentmentioning

confidence: 99%

Section: Appendix B – Hazard Identification and Characterisationmentioning

confidence: 99%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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“…These clinical signs were possibly associated with overall subchronic toxicity of NiCl 2 which is a one of water-soluble nickel compounds that have been shown to be more toxic than the less soluble ones. On the other hand, NiCl 2 has no significant retention and cumulative effect in the body and this may be the reason for no mortality in the present study besides the low used dose rate of NiCl 2 [15,32].…”

Section: Resultsmentioning

confidence: 56%

“…(1): control group was kept on distilled water , Rats in Gp. (2) received NiCl 2 daily at a dose of 0.75 mg/kg BW on the basis of LD 50 which equal to 105 mg/kg ( used dose equal to LD 50 /140) as a 0.5 ml/ rat [14,15]. Gp.…”

Section: Experimental Designmentioning

confidence: 99%

Protective Effect of Angelica sinensis Extract and Origanum majorana Oil on Hepatic and Renal Toxicities Induced by Nickel Chloride in Male Albino Rats

Hashem

Ismail

Hassan³

2019

Zagazig Veterinary Journal

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The present study was accomplished to evaluate the efficacy of Angelica sinensis root extract and Origanum majorana oil on subchronic toxicity of nickel chloride (NiCl 2 ) in albino rats by studying the changes in the biochemical parameters, lipid peroxidation and antioxidant status related to the liver and kidneys. This study was carried out on sixty male albino rats with average body weight (120 ± 10 g), which were divided into 6 equal groups. Gp.(1): were kept as control on distilled water, rats in Gp. (2) received NiCl 2 (0.75 mg/kg BW), Gp. (3) received A. sinensis root extract (300 mg/kg BW) and Gp. (4) received O. majorana oil (0.5 ml/kg BW). NiCl 2 intoxicated rats in Gp. (5) and Gp. (6) were administered A. sinensis root extract and O. majorana oil at the same former doses, respectively. The treatments were daily and orally for 4 weeks. Blood and tissue samples were collected for performing the different experimental analysis after 4 weeks from starting the treatments. Comparing with the control group, results showed that NiCl 2 significantly increased serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activities and serum bilirubin, triglycerides, total cholesterol, urea and creatinine concentrations, besides hepatic and renal malondialdehyde concentration, while serum total proteins, albumin and hepatic and renal glutathione, glutathione peroxidase, superoxide dismutase and catalase levels were significantly decreased. A. sinensis root extract and O. majorana oil has no adverse effects and worked on amelioration the various alterations in estimated analytes in combined treated groups. In conclusion, NiCl 2 caused hepatic and renal injuries besides the induction of lipid peroxidation and reducing the antioxidant enzymes activities in these organs. Moreover, both of A. sinensis root extract and O. majorana oil provided significant protection against harmful effects of NiCl 2 with superiorty of A. sinensis root extract .

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“…Lines 964-969 (mice), lines 1022-1030 (rats): Testicular effects are discussed for mice (Pandey et al, 1999;Pandey and Srivastava, 2000) and rats (Lambade et al, 2015). The micrographs published in Pandey et al (1999) are consistent with changes seen in testes that were improperly fixed with formalin which can result in incomplete penetration of the fixative and allows degradation of the tissue prior to fixation.…”

Section: Summary Of Uncertaintiesmentioning

confidence: 94%

Outcome of a public consultation on the draft update of the risk assessment of nickel in food and drinking water

2020

EFSA Supporting Publications

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Clinicopathological studies of experimentally induced Nickel Chloride in Wistar rats (Rattus norvegicus)

Cited by 4 publications

References 0 publications

Update of the risk assessment of nickel in food and drinking water

Update of the risk assessment of nickel in food and drinking water

Protective Effect of Angelica sinensis Extract and Origanum majorana Oil on Hepatic and Renal Toxicities Induced by Nickel Chloride in Male Albino Rats

Outcome of a public consultation on the draft update of the risk assessment of nickel in food and drinking water

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