Clinicopathological spectrum of mycosis fungoides

Kazakov, Dmitry V.; Burg, G.; Kempf, Werner

doi:10.1111/j.1468-3083.2004.00937.x

Cited by 240 publications

(268 citation statements)

References 196 publications

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“…The episodes of high fever and blisters are very unusual although blister formation has been documented in a patient with MF (so-called MF bullosa), whereas fever and symptoms of rheumatic diseases are not uncommonly observed in CGD-TCL. 15,16 The reason for recurrent blister formation is unknown. It can be speculated that cytokines released in a cyclic manner result in blister formation, fever, and arthralgias.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Kempf¹,

Kazakov

Scheidegger

et al. 2014

The American Journal of Dermatopathology

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Cutaneous [gamma]/[delta]+ T-cell lymphoma (CGD-TCL) is a rare but aggressive lymphoma associated with a poor prognosis in most patients. The clinicopathological spectrum is variable including predominantly epidermotropic infiltrates manifesting with patches and plaques or tumors with dermal and/or subcutaneous infiltrates. The diagnosis of CGD-TCL requires the demonstration of a [gamma]/[delta]+ phenotype by immunohistochemistry. We report 2 patients with epidermotropic cutaneous T-cell lymphomas displaying a [gamma]/[delta]+ phenotype, but exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-to-medium-sized lymphocytes. exhibiting an indolent course. In one patient, the clinical presentation was similar to mycosis fungoides in patch and plaque stage, but recurrent blister formation within the lesions was observed accompanied by fever and arthralgias, whereas the second patient presented with 2 localized erosive plaques on the left temple and dense epidermotropic and dermal diffuse and folliculotropic infiltrates of atypical small-tomedium-sized lymphocytes. These cases corroborate the view that expression of a g/d+ phenotype in cutaneous T-cell lymphomas per se does not portend a worse prognosis and that CGD-TCL may represent a clinically and prognostically heterogeneous group.

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Section: Discussionmentioning

confidence: 99%

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Kempf¹,

Kazakov

Scheidegger

et al. 2014

The American Journal of Dermatopathology

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“…1A). However, a broad range of MF variants have been described with differences in tropism (e.g., follicular MF), distribution (e.g., palmoplantar MF), pigmentation (e.g., hypopigmented and hyperpigmented variants) and focality (e.g., unilesional MF), some of which are formally recognized in the WHO-EORTC classification (see Table I) [2,102].…”

Section: Mycosis Fungoidesmentioning

confidence: 99%

Cutaneous T‐cell lymphoma: 2011 update on diagnosis, risk‐stratification, and management

Wilcox

2011

American J Hematol

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Disease overview: Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis fungoides (MF) or Sézary syndrome (SS).Diagnosis: The diagnosis of MF or SS requires the integration of clinical and histopathologic data.Risk‐adapted therapy: Tumor, node, metastasis, and blood (TNMB) staging remains the most important prognostic factor in MF/SS and forms the basis for a “risk‐adapted,” multidisciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin‐directed therapies is preferred, as both disease‐specific and overall survival for these patients is favorable. In contrast, patients with advanced‐stage disease with significant nodal, visceral, or blood involvement are generally approached with biologic‐response modifiers, denileukin diftitox, and histone deacetylase inhibitors before escalating therapy to include systemic, single‐agent chemotherapy. Multiagent chemotherapy may be used for those patients with extensive visceral involvement requiring rapid disease control. In highly‐selected patients with disease refractory to standard treatments, allogeneic stem‐cell transplantation may be considered. Am. J. Hematol., 2011. © 2011 Wiley‐Liss, Inc.

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“…The skin rash in MF patients usually consists of patches, plaques or tumors that may have a long natural history; however many atypical variants have also been reported 1 .…”

Section: Introductionmentioning

confidence: 99%

“…Ichthyosiform eruption as a specific manifestation of MF is very rare and this represents 1.8% of all MF cases. Only a few cases of ichthyosiform eruption as a specific manifestation of MF have currently been reported in the English literature [1][2][3][4][5][6][7][8] . We report here on the case of a 63-year-old Korean man who presented with ichthyosiform eruption and a histological pattern of MF.…”

Section: Introductionmentioning

confidence: 99%

Mycosis Fungoides as an Ichthyosiform Eruption

et al. 2009

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Ichthyosiform eruption as a specific manifestation of mycosis fungoides is very rare and only a few such cases have currently been reported in the medical literature. A 63-year-old Korean man presented with a 4-year history of a pruritic ichthyotic eruption. There was no personal or family history of ichthyosis or atopy. The ichthyosiform skin changes involved the abdomen, arms, thighs and shins. The face, palms and soles were spared. There was no peripheral lymphadenopathy or organomegaly. The typical lesions of mycosis fungoides were not present. The results of the routine investigations were normal or negative. A skin biopsy specimen revealed the findings of early mycosis fungoides. He was successfully treated with photochemotherapy. (Ann Dermatol 21(2) 182∼184, 2009)

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Clinicopathological spectrum of mycosis fungoides

Cited by 240 publications

References 196 publications

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Two Cases of Primary Cutaneous Lymphoma With a γ/δ+ Phenotype and an Indolent Course

Cutaneous T‐cell lymphoma: 2011 update on diagnosis, risk‐stratification, and management

Mycosis Fungoides as an Ichthyosiform Eruption

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