Mycosis Fungoides as an Ichthyosiform Eruption

Abstract

Ichthyosiform eruption as a specific manifestation of mycosis fungoides is very rare and only a few such cases have currently been reported in the medical literature. A 63-year-old Korean man presented with a 4-year history of a pruritic ichthyotic eruption. There was no personal or family history of ichthyosis or atopy. The ichthyosiform skin changes involved the abdomen, arms, thighs and shins. The face, palms and soles were spared. There was no peripheral lymphadenopathy or organomegaly. The typical lesions of mycosis fungoides were not present. The results of the routine investigations were normal or negative. A skin biopsy specimen revealed the findings of early mycosis fungoides. He was successfully treated with photochemotherapy. (Ann Dermatol 21(2) 182∼184, 2009)

Ichthyosis as a paraneoplastic syndrome and atypical variant of mycosis fungoides: two cases report

“…Clinical remission in IMF is obtained with nonaggressive therapies such as topical treatments, PUVA therapy and Ultraviolet light B (UVB) [12,13]. A significant remission was observed, after 5 months of UVB 311 therapy 3 times a week in the case of our first patient.…”

“…According to the clinical findings, IMF can be divided into 3 types: as the sole manifestation of the disease, in conjunction with additional atypical findings of MF and in combination with the classic types of MF [12]. Among cases presented by Morizane et al [9], diagnosis of IMF should be only considered when it is the sole manifestation of MF, as in our first case.…”

Ichthyosis with superimposed mycosis fungoides, a rare case of generalized erythema with malaise

“…Ichthyosiform eruption as a manifestation of mycosis fungoides is rare; furthermore, ichthyosis with superimposed mycosis fungoides is scarcely ever seen and just a few such cases have been presented in the medical literature. [ 10 11 ] Ichthyosiform MF can be subdivided into three types on the basis of the clinical findings: ichthyosiform lesions one and only, ichthyosiform eruption accompanied by classical MF, ichthyosiform eruption in combination with other atypical variants of MF. [ 10 11 ]…”

“…[ 4 5 6 7 8 9 ] Amid them, ichthyosiform MF is not as well-understood as other forms of MF, and this particular manifestation as an ichthyosiform eruption of mycosis fungoides is scarcely ever seen, and only a few cases have been documented in the medical literature. [ 10 11 ] Moreover, ichthyosiform lesions may indicate the presence of an underlying systemic disease, paraneoplastic syndrome, or an atypical manifestation of cutaneous T-cell lymphoma. [ 12 13 ] Hence, determining the accurate etiology is important to establish the correct diagnosis and subsequently facilitate its management.…”

Ichthyosiformer Morphenwandel einer erythrodermen Mycosis fungoides unter extrakorporaler Photopherese-Therapie – klinisch relevant?

“…Die ichthyosiforme MF (iMF) als solche ist bekannt und tritt in 1,8 -3,5 % der Patienten mit einer MF auf[5 -9]. Sie kann nochmals in 3 Subvarianten eingeteilt werden: 1) ichthyosiforme Eruptionen als solitäre Manifestation der Erkrankung, 2) ichthyosiforme Eruption in Verbindung mit zusätzlichen atypischen Anzeichen einer MF und 3) ichthyosiforme Eruption in Kombination mit der klassischen Variante der MF[9]. Klinisch manifestiert sich die iMF mit hyperpigmentierten, xerotisch-schuppenden sowie flachen ichthyosiformen Plaques.…”