Clinicopathological profile of colorectal cancer managed at a university teaching hospital, Nepal

Abstract

Introductions: Colorectal carcinoma is the third most common cancer worldwide. The incidence is increasing in developing countries including Nepal. The aim of this study is to find out the clinicopathological pattern of colorectal carcinoma locally. 
 Methods: Data were recorded retrospectively by reviewing the charts of the patients who were diagnosed and treated for in patients having colorectal cancer managed during three years period of 2016-9 at Patan Hospital, the university teaching hospital of Patan Academy of health sciences, Nepal. Clinicopathological profile, age, gender, surgery, histopathological findings were descriptively analised. 
 Results: There were 36 colorectal cancer patients, male 20 (56%) and females 16 (44%), mean age 56.9 years (range 24 to 89). Curative surgery was possible in 17 (47.2%) and adenocarcinoma of moderate differentiation was found in 25 (70%) of the resected specimen. 
 Conclusions: Colorectal carcinoma was found in old age, slightly more in male than female, adenocarcinoma being most common histology type.

Comparative Study of Colorectal Cancer Based on Tumor Location in Adolescent and Young Adult Population in Nepal

“…For left-sided CRC, common histologic subtypes were moderately differentiated, mucinous, and well-differentiated. This finding was similar to another Nepalese data of patients across all ages, where moderately differentiated (70%) was the most common histology, followed by mucinous (20%) 12 whereas, in another study of childhood and adolescence patients, mucinous (62%) was most common histology. 7,16 The various subtypes within the histology group were compared as per the tumor location however the difference was not significant.…”

“…10 In a study done across all ages in one of the teaching hospitals of Nepal, pain abdomen (86%) and bleeding per rectum (55%) were common symptoms at presentation. 12 Our study showed more left-sided tumors compared to right-sided. The left-sided tumor was more common in metastatic CRC in a study with a large sample size 9 while in a large data of patients across all ages, 67.03% of patients had right-sided CRC while 32.96% patients had left-sided CRC.…”

“…The most common site of the tumor was the rectum (49.18%) in our study and other studies also showed a similar distribution of tumor site. 10,12,15 The most common histology was adenocarcinoma (95.08%). The most common histologic subtypes in right-sided CRC were moderately differentiated followed by mucinous, poorly differentiated, and welldifferentiated.…”

Clinicopathological profile of colorectal carcinoma in a tertiary care teaching hospital in Pokhara, Nepal

“…The mean age of presentation was 54.7 years in a multicenter study comprising of 1525 patients at Colombia 7 . In a similar study by Paudyal et al 8 in Nepal and Kumar et al 9 in Oman, the mean age was 56.9 and 56 years respectively with male predominance.…”

“…In the current study, 4.8% patients were aged below 40 years of age. In a previous study in Nepal by Paudyal et al 8 , the incidence of colorectal cancer in young below 40 years of age was even higher (16.7%). Colorectal carcinomas were detected at even lower ages (less than 35 years) among 19.25% patients by Bhat et al 6 Bohorquez et al 7 had also reported 26.5% of cases diagnosed with CRC before the age of 50 years.…”