Clinicopathological profile of clear cell renal cell carcinoma

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer with aggressive behavior. Tumor stage and grade are important parameter in diagnosis. Data about the clinical and pathology profile of ccRCC in Indonesia is limited, therefore further information is needed. The study aimed to determine clinicopathologic profile of ccRCC in Soetomo Academic General Hospital (SAGH). This descriptive study was conducted retrospectively with cross-sectional approach. Clinical and histopathological archives of ccRCC specimen were retrieved during January 2016 to December 2020. The total number of ccRCC cases obtained was 38 cases, the most cases (11) occurred in 2016. The average of patient’s age was 55.64 years. Patients were predominantly male (71.1%), with a ratio to female 2.5:1. The tumors mostly filled the entire kidney, in 15 (39.5%) cases. Most pT stage distribution was pT2, in 15 (39.5%) cases. Most N stage distribution was N0, in 23 (60.5%) cases. Only 5 (13.2%) cases showed multiple pulmonary nodules which suspected to be metastatic (M1). The most common tumors grade was G4, in 17 (44.7%) cases. In conclusion, ccRCC patient were predominantly male, tumors mostly high grade, filled entire kidney, not penetrated renal capsule, and not metastasize to regional lymph nodes.

Study of the genetic polymorphisms of the promoter region of TNF- in Thi-Qar patients affected by psoriasis

“…A few examinations have discovered these distinctions just in patients with beginning stage psoriasis (5,6), or just in male patients (6). Studies did on the eastern populace they have not recognized contrasts in the conveyance of these polymorphisms (7,35,36). We have not discovered huge contrasts in dissemination of the TNF -308 genotype, similar to others creators (4,7,9,10,35,36).…”

“…Studies did on the eastern populace they have not recognized contrasts in the conveyance of these polymorphisms (7,35,36). We have not discovered huge contrasts in dissemination of the TNF -308 genotype, similar to others creators (4,7,9,10,35,36). Be that as it may, a few investigations have discovered a higher recurrence of TNF-308GG genotype in instances of moderate-serious psoriasis (37), or higher recurrence of bearers of the TNF -308G allele in patients with beginning stage psoriasis (5,8,33,38).…”

Ameloblastoma–A rigorous odontogenic tumours of the jaws

“…Their research confirmed that maxillary ameloblastoma is more common in men and develops at an older age, which explains the demographics of their patient population. 17,21 This is disputable to the current study because the majority of the tumour occurrence was in the mandible compared to maxilla.…”

Therapeutic efficacy of time-dependent cetuximab on experimentally induced hamster buccal pouch carcinoma

“…(82,83) There was more activity in the MEK/ERK1/2 and Akt signaling pathways after medication with cetuximab, which could be because cetuximab does not work for people with OSCC. (84) also found a link between increased EMT markers and cetuximab resistance in 20 pre-and post-cetuximab OSCC biopsy samples. As a result, inhibiting EGFR/PI3K/Akt/mTOR phosphorylation is a promising method for preventing the carcinogenic potential of oral cancer.…”