Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients

Kulig, Jan; Popiela, T; Kołodziejczyk, Piotr; Sierżęga, Marek; Jędrys, Joanna; Szczepanik, Antoni M.

doi:10.1007/s00423-007-0208-z

Cited by 36 publications

(54 citation statements)

References 44 publications

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“…This finding is similar to other reports on young GC patients [13,16] and it may be attributable to a lack of screening endoscopy in the typically asymptomatic young population. Population screening for GC varies between countries in both methods and screening intervals.…”

Section: Discussionsupporting

confidence: 81%

“…However, there has been some concern about a trend toward steadily increasing GC in young patients over the past few decades and studies were conducted to define the demographic, clinicopathologic and prognostic factors of GC in young patients [10][11][12]. The incidence of GC in patients aged 40 years or younger ranges from 4.6 to 6.2 % [12][13][14]. The clinicopathological features of GC in young patients are known to be different from older patients.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

et al. 2014

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Background There is little known about the clinicopathological features and the predictors of survival in extremely young adult patients aged 18-30 years. The aim of this study was to identify clinicopathological features and clinical outcomes for the overall population and for a resectable subgroup of gastric cancer patients aged 18-30 years.Methods From January 2004 to December 2010, 207 patients aged between 18 and 30 years old were diagnosed with gastric cancer and treated at the Asan Medical Center. Clinical findings, histopathological parameters and outcomes were reviewed retrospectively. Patients were further divided into 2 groups according to tumor resectability and then clinicopathological factors that affect tumor resectability and clinical outcomes were analyzed. Results Clinicopathological characteristics of study population showed a predominance of females, undifferentiated tumors, diffuse-type cancers, and advanced gastric cancer. The overall resectability rate was 70.0 % and the median follow-up period was significantly longer in the resectable tumor group (P \ 0.001). Significant prognostic predictors for overall survival in overall patients were higher CEA levels (P = 0.016), larger tumor size (P \ 0.001), unresectability (P = 0.006), and presence of lymphovascular invasion (P = 0.012) in a multivariate analysis. Significant prognostic factors for overall survival in patients with resectable disease included larger tumor size ([4 cm), lymphovascular invasion and higher CEA level in the multivariate analysis. Conclusions Gastric adenocarcinomas in young adult patients aged 18-30 years have unique clinicopathological features. Early detection in a resectable state and subsequent complete resection could increase survival period in young patients with gastric cancer.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

et al. 2014

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“…This corresponds with other investigations [28]. In our study there was no significant influence in overall survival related to tumor localization.…”

Section: Discussionsupporting

confidence: 93%

Gastric surgery at the department of surgery in Graz*

et al. 2011

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“…Factors that contribute to the poor prognosis of gastric cancer in the young include delayed detection, resulting in an advanced stage at presentation, diffuse infiltration of the tumor and a poorly differentiated histology [1,4,10]. On the other hand, recent studies have indicated that prognosis in young patients is equivalent to [7,11,12] or better than that in middle-aged patients with cancers at the same stage [8,9,13,14]. Thus, the concept of gastric cancer having a poorer prognosis in relatively young patients remains controversial.…”

Section: Introductionmentioning

confidence: 98%

“…However, the results of previous studies focusing on young patients with gastric cancer have not been convincing because of the small number of patients and lack of recent data. Moreover, the definition of ''early onset'' has varied among studies (e.g., disease occurrence at less than 30, 35, 40 or 45 years of age [3,10,13,14]). In addition, few studies have compared young and middle-aged patients epidemiologically or focused specifically on the clinicopathological characteristics of younger patients.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of gastric cancer in young patients

et al. 2015

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Background Early-onset gastric cancer is relatively rare. To evaluate the clinicopathological features and surgical outcome of young patients with gastric cancer, this retrospective comparative study was conducted. Methods From 2000 to 2010, 4882 patients underwent surgery for gastric adenocarcinoma in our institution. A total of 136 patients under 40 years old were enrolled as the young group, and a total of 1435 patients aged between 60 and 69 were identified as the control group for this study. The patient's characteristics, pathological findings, surgical and clinical outcomes were reviewed, and the risk factors of recurrence were compared between the two groups. Results Among the young group, patients had significantly fewer comorbidities and postoperative complications. The patient proportion having 7 or more lymph node metastases was higher in the young group (25 %) than in the control group (16 %). The presence of lymph node metastasis was identified as a strong risk factor for recurrence (odds ratio = 4.31) in the young group according to the results of the step-wise logistic regression analysis. Although the disease-specific survival at stage II was relatively better in the young group (p = 0.0439) than in the control group, there were no significant differences in overall survival for all stages. Conclusion Early-onset gastric cancer is likely to present lymph node metastases. The survival rate of gastric cancer in young patients was equivalent to that in patients in their 60s, which is the typical age at onset.

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Clinicopathological profile and long-term outcome in young adults with gastric cancer: multicenter evaluation of 214 patients

Abstract: GC in young adults demonstrates only minor deviations from the general population with a similar long-term outcome.

Cited by 36 publications

References 44 publications

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Gastric surgery at the department of surgery in Graz*

Clinicopathological features of gastric cancer in young patients

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