Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Park, Hee Jung; Ahn, Ji Yong; Jung, Hwoon‐Yong; Lim, Hyun; Lee, Jeong Hoon; Choi, Kyeong‐Hee; Kim, Do Hoon; Choi, Kee Don; Song, Ho June; Lee, Gin Hyug; Kim, Jin-Ho

doi:10.1007/s10120-013-0331-1

Cited by 63 publications

(70 citation statements)

References 37 publications

(47 reference statements)

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“…4 Unlike the characteristics of advanced-stage cancer patients, the percentage of tumors located in the lower third for patients at the early stage were 71.9%, which was higher than that reported in Japan, 3,6 China, 10 and Korea. 9 The percentages of tumors located in the middle and upper thirds were reported 41.4% and 20.1% in Japan, 6 similar to that reported in China (60.0% in the middle and upper thirds). 13 The tumors of young gastric cancer patients at an advanced stage were located more commonly in the upper or middle third, compared with that in young EGC patients who underwent ESD.…”

Section: Discussionsupporting

confidence: 68%

“…1 However, most previous studies on young gastric cancer patients showed a female predominance, with a lower male-to-female sex ratio (0.54:1∼1.26:1). 3,6,9,10,13 The male-to-female sex ratio of young gastric patients who underwent ESD was 0.77:1 in our study. This corresponds to findings in young gastric patients with not only advanced stage but also early stage of disease.…”

Section: Discussionmentioning

confidence: 49%

“…3,13,18 Furthermore, the prognosis and survival rate of young patients after curative resection were better than those of older patients. [5][6][7]9,13 Owing to awareness about aggressive tumor biology and rapid progression in young patients with gastric cancer, there were concerns about endoscopic local treatment in young patients with EGC, even for those that met the expanded indication for ESD. In the past, physicians and patients tended to choose surgery over ESD because of concerns about rapid progression and the possibility of recurrence of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9][10] Because most previous studies included young patients with early gastric cancer (EGC) and advanced gastric cancer, the enrolled young patients showed more advanced-stage and metastatic disease at the time of diagnosis. Owing to awareness about rapid progression in young patients, there are concerns about endoscopic treatment in young patients with EGC that met the expanded indication of endoscopic submucosal dissection (ESD).…”

Section: Introductionmentioning

confidence: 99%

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Clinical Outcomes of Endoscopic Submucosal Dissection in Patients under 40 Years Old with Early Gastric Cancer

Hahn

Lee

Park

et al. 2016

Korean J Helicobacter Up Gastrointest Res

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Background/Aims: The clinicopathologic features of gastric cancer in young patients are different from those of older patients. However, endoscopic submucosal dissection (ESD) is performed regardless of age. The purpose of this study was to characterize younger patients (≤40 years) who underwent ESD for early gastric cancer (EGC) and analyze the results of ESD. Materials and Methods: From January 2006 to June 2014, 55 patients aged 40 years or younger with newly diagnosed EGC underwent ESD at two tertiary hospitals. The clinicopathologic features of EGC and clinical outcomes of ESD in these young patients were reviewed retrospectively. Results: A total 55 patients with 57 EGC lesions underwent ESD. Female sex, superficial flat or depressed lesions, and undifferentiated histology were more common in younger patients than in older patients in our institutional ESD cohort. The en bloc resection rate was 92.7% and the complete resection rate was 94.5%. Although there was a high proportion of undifferentiated cancer in the younger patient group, the curative resection rate was 72.7%. Among 15 patients with non-curative resection, 4 patients underwent additional surgery and 1 patient underwent argon plasma coagulation at the ESD ulcer margin. Eight patients were placed under close surveillance without additional treatment, and no recurrent tumors developed, with a median follow-up period of 37.2±23.6 months. Conclusions: Younger EGC patients who underwent ESD showed the typical characteristics seen in younger patients with gastric cancer. ESD in younger EGC patients showed comparable outcomes to those in patients with undifferentiated EGC in general.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Outcomes of Endoscopic Submucosal Dissection in Patients under 40 Years Old with Early Gastric Cancer

Hahn

Lee

Park

et al. 2016

Korean J Helicobacter Up Gastrointest Res

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“…The survival rate of patients with GC remains relatively poor, since the majority of cases are already in the late stage at diagnosis, and surgery and chemotherapy result in an unsatisfactory prognosis. Serum tumor markers are useful for diagnosis, for predicting survival rates and for monitoring recurrence following surgery (2,3). Carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9 and CA72-4 are the most frequently used clinical markers.…”

Section: Introductionmentioning

confidence: 99%

Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer

Zhang

Zhao

2015

Molecular and Clinical Oncology

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Abstract. The sensitivity of three biomarkers, carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9 and CA72-4, in combination has been identified to be greater than that of any of the biomarkers considered in isolation in cases of gastric cancer (GC). However, the fundamental cause underlying this phenomenon remains to be fully elucidated. In the present study, the differences and correlation of these three biomarkers were investigated in patients with GC in order to determine how the three biomarkers in combination work more effectively compared with any of the biomarkers considered alone. The serum levels of CEA, CA19-9 and CA72-4 of 216 patients with gastric adenocarcinoma were analyzed on admission to hospital. The differences in positive rates and the serum levels of CEA, CA19-9 and CA72-4 were analyzed using the χ 2 test and the non-parametric Wilcoxon two-sample test. Phi (f) correlation analysis was used to study the correlation among the expression (positive or not) levels of CEA, CA19-9 and CA72-4. The correlation among the serum levels of biomarkers was analyzed using Spearman's test. The results demonstrated that the combined positive rate of CEA, CA19-9 and CA72-4 was significantly higher compared with the individual CEA, CA19-9 and CA72-4 positive rates (44.91% vs. 22.69, 18.98 and 22.69%, respectively; all P<0.05). The positive rate of CA19-9 and CA72-4 in the extent of the primary tumor/involvement of regional lymph node/distant metastases (TNM)-III/IV stage subgroup was higher compared with that in the TNM-I/II subgroup (χ 2 =5.902, P=0.015; χ 2 =8.009, P=0.005), although not the positive rate of CEA (χ 2 =0.302, P= 0.583). A significant correlation was identified between the expression level of CEA and CA72-4 (f correlation coefficient=0.182; P=0.008) and between that of CA19-9 and CA72-4 (f correlation coefficient= 0.189; P= 0.006), although not between that of CEA and CA19-9 (f correlation coefficient=0.048; P=0.482) in the total number of patients with GC. A significant correlation was also identified between the serum levels of CEA and CA19-9, of CEA and CA72-4 and of CA19-9 and CA72-4 (Spearman's correlation coefficient=0.231, -0.271 and 0.167; P=0.001, P<0.0001 and P=0.014, respectively). The present study indicated that there was only a weak correlation between the positive rate of CEA and CA72-4 and between that of CA19-9 and CA72-4, and no correlation was identified between the positive rate of CEA and CA19-9, even if a correlation was identified between the serum levels of the biomarkers. The present study suggested that the evidence that the sensitivity of the three biomarkers in combination is greater than that of any of the biomarkers taken in isolation is due to less co-presentation of CEA, CA19-9 and CA72-4 in patients with GC.

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Nomogram for predicting the overall survival of patients with early‐onset prostate cancer: A population‐based retrospective study

Qiao

Zheng

et al. 2022

Cancer Medicine

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Background The incidence of early‐onset prostate cancer (PCa) has increased significantly over the past few decades. It is necessary to develop a prognostic nomogram for the prediction of overall survival (OS) in early‐onset PCa patients. Methods A total of 23,730 early‐onset PCa patients (younger than 55 years old) between 2010 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were enrolled for the current study, and randomly separated into the training cohort and the validation cohort. 361 eligible early‐onset PCa patients from The Cancer Genome Atlas‐Prostate Adenocarcinoma (TCGA‐PRAD) cohort were obtained as the external validation cohort. Independent predictors were selected by univariate and multivariate Cox regression analysis, and a prognostic nomogram was constructed for 1‐, 3‐, and 5‐year OS. The accurate and discriminative abilities of the nomogram were evaluated by the concordance index (C‐index), receiver operating characteristic curve (ROC), calibration plot, net reclassification index (NRI), and integrated discrimination improvement (IDI). Results Multivariate Cox analysis showed that race, marital status, TNM stage, prostate‐specific antigen, Gleason score, and surgery were significantly associated with poor prognosis of PCa. A nomogram consisting of these variables was established, which had higher C‐indexes than the TNM system (training cohort: 0.831 vs. 0.746, validation cohort: 0.817 vs. 0.752). Better AUCs of the nomogram than the TNM system at 1, 3, and 5 years were found in both the training cohort and the validation cohort. The 3‐year and 5‐year AUCs of the nomogram in the TCGA‐PRAD cohort were 0.723 and 0.679, respectively. The calibration diagram, NRI, and IDI also showed promising prognostic value in OS. Conclusions We developed an effective prognostic nomogram for OS prediction in early‐onset PCa patients, which will further assist both the precise clinical treatment and the assessment of long‐term outcomes.

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Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Cited by 63 publications

References 37 publications

Clinical Outcomes of Endoscopic Submucosal Dissection in Patients under 40 Years Old with Early Gastric Cancer

Clinical Outcomes of Endoscopic Submucosal Dissection in Patients under 40 Years Old with Early Gastric Cancer

Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer

Nomogram for predicting the overall survival of patients with early‐onset prostate cancer: A population‐based retrospective study

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