Clinicopathological importance of Ki-67, p27, and p53 expression in gastric cancer

Çalık, Muhammet; Demirci, Elif; Altun, Eren; Çalık, İlknur; Gündoğdu, Özge Beyza; Gürsan, Nesrin; Gündoğdu, Betül; Albayrak, Mevlüt

doi:10.3906/sag-1311-107

Cited by 24 publications

(15 citation statements)

References 39 publications

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“…p27 is a cyclin-dependent kinase inhibitor acting as a tumor suppressor by preventing cellcycle progression. A decrease of p27 expression was reported in gastric cancer and it was associated with metastasis in patients with gastric carcinoma [18,19]. Our findings on p27-induced phosphorylation and the decrease of cell proliferation after KRT17 knockdown in gastric adenocarcinoma cells comes as a reflection of the observation by Escobar-Hoyos et al of an inverse correlation between KRT17 and p27 KIP1 expression.…”

Section: Krt17 Expression Was Maintained At a Low Level Insupporting

confidence: 85%

Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells

Chivu‐Economescu¹,

Dragu²,

Necula

et al. 2017

Gastric Cancer

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Section: Krt17 Expression Was Maintained At a Low Level Insupporting

confidence: 85%

Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells

Chivu‐Economescu¹,

Dragu²,

Necula

et al. 2017

Gastric Cancer

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“…In accordance with the previous reports [31], patients with p53-positive and HIF-1α-positive gastric cancer have worse prognosis, compared with those with double negative cancers. Our study on EOGC further suggests that p53-negative patients have a significantly better outcome than p53-positive patients, which is in disagreement with a most recent Turkish report because of the different study population and a high percentage of elderly patients investigated [32]. We show that overexpression of p53 is associated with younger age but advanced stage of EOGC, suggestive of an aggressive biology behavior.…”

Section: Discussioncontrasting

confidence: 97%

Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers

Zhang

Shi

et al. 2016

Cancer Medicine

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Early‐onset gastric cancer (EOGC) is predominant in females, diffuse histology, and hereditary pattern. Germline mutation of CDH1 and p53 has been reported previously and female dominance was speculated to be associated with estrogen and its receptors. Expression of E‐cadherin, estrogen receptor α (ER α), estrogen receptor β (ER β), and p53 in EOGC remains unclear, which was the focus of this study, to assess clinical significance of their expression in EOGC. The expression of E‐cadherin, ER α, ER β, and p53 in tumors and normal tissues from surgically resected EOGCs was assessed by immunohistochemistry (n = 139) and Western blot (n = 7) methods, respectively. The expression in tumor tissues was significantly higher for ER α, ER β, and p53, but lower for E‐cadherin, compared to uninvolved mucosa. Positive staining of ER β and p53 was more frequently observed in younger patients with advanced TNM stages. For E‐cadherin, significant correlation was observed between the immunopositivity and TNM stages IA+IB. P53‐negative patients had significantly better outcomes than p53‐positive patients. Significant association between expression of E‐cadherin and histologic types was found in familial, but not in sporadic, EOGC. In conclusion, our results demonstrated E‐cadherin may have a role in initiation of EOGC and positive ER β and p53 expression may partially explained early‐onset and tumor progression of EOGC.

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“…[4][5][6] The p53 protein coded by abnormal p53 gene had a longer half-life period so that it could be detected by immunohistochemistry (IHC). Several clinical studies have proved the prognostic value of p53 positive (overexpression or positivity) in patients with esophageal squamous cell carcinoma, 7 gastric cancer, 8,9 gallbladder cancer, 10 pancreatic cancer, 11 and non-small cell lung cancer. 12 But the prognostic value of p53 positive in CRC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of p53 positive in colorectal cancer: A retrospective cohort study

et al. 2017

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This retrospective cohort study aimed to discuss the prognostic value of p53 positive in colorectal cancer. A total of 124 consecutive patients diagnosed with colorectal cancer were evaluated at the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College from 1 January 2009 to 31 December 2010. The expression of p53 in colorectal cancer was examined by immunohistochemistry. Based on the expression levels of p53, the 124 patients were divided into a p53 positive group and a p53 negative group. In this study, 72 patients were in the p53 positive group and 52 in the p53 negative group. The two groups were well balanced in gender, age, body mass index, American Society of Anesthesiologists scores, and number of lymph nodes harvested. p53 positive was associated with carcinoembryonic antigen ≥5 ng/mL (p = 0.036), gross type (p = 0.037), degree of tumor differentiation (p = 0.026), pathological tumor stage (p = 0.019), pathological node stage (p = 0.004), pathological tumor-node-metastasis stage (p = 0.017), nerve invasion (p = 0.008), and vessel invasion (p = 0.018). Tumor site, tumor size, and pathological pattern were not significantly different between these two groups. Disease-free survival and overall survival in the p53 positive group were significantly shorter than the p53 negative group (p = 0.021 and 0.025, respectively). Colorectal cancer patients with p53 positive tended to be related to a higher degree of malignancy, advanced tumor-node-metastasis stage, and shorter disease-free survival and overall survival. p53 positive was independently an unfavorable prognostic marker for colorectal cancer patients.

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Clinicopathological importance of Ki-67, p27, and p53 expression in gastric cancer

Cited by 24 publications

References 39 publications

Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells

Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells

Expression profile of E‐cadherin, estrogen receptors, and P53 in early‐onset gastric cancers

The prognostic value of p53 positive in colorectal cancer: A retrospective cohort study

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