Clinicopathological Features in Endometrial Carcinoma Associated With Lynch Syndrome in China

Wang, Yingmei; Xue, Fengxia; Broaddus, Russell R.; Tao, Xin; Xie, Shuai; Zhu, Yanbin

doi:10.1111/igc.0b013e3181a12fb9

Cited by 19 publications

(27 citation statements)

References 28 publications

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“…To our knowledge, there was only one report of an association of diabetes with HNPCC-associated cancer, which describes that the prevalence of diabetes was not different between those with HNPCC and those without HNPCC. 11 The result of our study is consistent with that in this previous study. 11 This finding should be confirmed in a larger population.…”

Section: Discussionsupporting

confidence: 93%

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Correlation Between Body Mass Index and Prevalence of Hereditary Nonpolyposis Colorectal Cancer in Korean Patients With Endometrial Cancer

Yoo

Joo

Seo

et al. 2012

International Journal of Gynecological Cancer

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Section: Discussionsupporting

confidence: 93%

“…11 The result of our study is consistent with that in this previous study. 11 This finding should be confirmed in a larger population.…”

Section: Discussionsupporting

confidence: 93%

Correlation Between Body Mass Index and Prevalence of Hereditary Nonpolyposis Colorectal Cancer in Korean Patients With Endometrial Cancer

Yoo

Joo

Seo

et al. 2012

International Journal of Gynecological Cancer

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“…Consistently with previous studies (14,16), no differences in the prevalence of DM or other chronic illnesses between the study groups were identified in the current study. With regard to BMI and other co-morbidities, the similarities between LS and sporadic EC patient cohorts may imply that sporadic and hereditary EC patients share a common risk factor profile.…”

Section: Discussionsupporting

confidence: 93%

“…These studies have suggested that EC women with a family history of CRC or suspected LS appear to be obese less often compared with EC women with no CRC family history (14)(15)(16)(17)(18). However, Lynch mutation carriers with EC have also been reported to be more obese compared with women with sporadic EC (16), whereas others (13) have reported no significant difference in BMI between these two patient groups, which is in line with the results presented in the current study.…”

Section: Discussionsupporting

confidence: 90%

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Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study

Aaltonen

Staff

Mecklin∥³

et al. 2017

Molecular and Clinical Oncology

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Abstract. Data available on lifestyle-associated hormonal and medical factors among endometrial cancer (EC)-affected women who carry the Lynch syndrome (LS) mutation is limited. The aim of the present retrospective case study was to compare the reproductive and medical history, as well as lifestyle-associated factors, among patients with LS and sporadic EC. The study population consisted of 50 verified germline mismatch repair (MMR) gene mutation carriers diagnosed with EC, and 110 sporadic EC patients. Data were collected using postal questionnaires. Apart from the mean age at the time of the EC diagnosis (LS, 48.7 years compared with sporadic patients, 55.2 years; P<0.0001), the characteristics of sporadic and LS EC patients were similar with regard to body mass index (BMI) at age 18, 40 or at the time of the survey, and smoking and alcohol consumption. LS women reported a significantly lower rate of spontaneous abortion (P= 0.043) and also more frequent use of contraceptives (P= 0.004). The prevalence of co-morbidities, including diabetes, atherosclerosis, hypercholesterolemia and hypertension, was similar between the LS and the sporadic groups. A trend for a higher prevalence of endometriosis among mutation carriers was detected (16.0 vs. 8.1%, P= 0.137). As anticipated, the prevalence of gastrointestinal tract, urinary tract and ovarian cancer was higher among the LS women (P<0.0001, P= 0.006 and P= 0.056, respectively). Co-morbidity and lifestyle-associated factors appeared to be comparable among patients with LS and sporadic EC. The reported difference in the use of contraceptives warrants further investigation. Future studies are also required to address the possible association between LS and endometriosis.

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Endometrial cancer in Lynch syndrome

Zhao

Chen

Zang

et al. 2021

Intl Journal of Cancer

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Lynch syndrome (LS) is an autosomal dominant inherited disease caused by germline pathogenic variants (PVs) in mismatch repair (MMR) genes. LS‐associated endometrial cancer (LS‐EC) is the most common extraintestinal sentinel cancer caused by germline PVs in MMR genes, including MLH1, MSH2, MSH6 and PMS2. The clinicopathologic features of LS‐EC include early age of onset, lower body mass index (BMI), endometrioid carcinoma and lower uterine segment involvement. There has been significant progress in screening, diagnosis, surveillance, prevention and treatment of LS‐EC. Many studies support universal screening for LS among patients with EC. Screening mainly involves a combination of traditional clinical criteria and molecular techniques, including MMR‐immunohistochemistry (MMR‐IHC), microsatellite instability (MSI) testing, MLH1 promoter methylation testing and gene sequencing. The effectiveness of endometrial biopsy and transvaginal ultrasound (TVS) for clinical monitoring of asymptomatic women with LS are uncertain yet. Preventive strategies include hysterectomy and bilateral salpingo‐oophorectomy (BSO) as well as chemoprophylaxis using exogenous progestin or aspirin. Recent research has revealed the benefits of immunotherapy for LS‐EC. The NCCN guidelines recommend pembrolizumab and nivolumab for treating patients with advanced or recurrent microsatellite instability‐high (MSI‐H)/mismatch repair‐deficient (dMMR) EC.

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Clinicopathological Features in Endometrial Carcinoma Associated With Lynch Syndrome in China

Cited by 19 publications

References 28 publications

Correlation Between Body Mass Index and Prevalence of Hereditary Nonpolyposis Colorectal Cancer in Korean Patients With Endometrial Cancer

Correlation Between Body Mass Index and Prevalence of Hereditary Nonpolyposis Colorectal Cancer in Korean Patients With Endometrial Cancer

Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study

Endometrial cancer in Lynch syndrome

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