Correlation Between Body Mass Index and Prevalence of Hereditary Nonpolyposis Colorectal Cancer in Korean Patients With Endometrial Cancer

Yoo, Heon Jong; Joo, Jungnam; Seo, Seung‐Woo; Kang, Sokbom; Yoo, Chong Woo; Park, Sang-Yoon; Lim, Myong Cheol

doi:10.1097/igc.0b013e31823b3650

Cited by 4 publications

(5 citation statements)

References 16 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistently with previous studies (14,16), no differences in the prevalence of DM or other chronic illnesses between the study groups were identified in the current study. With regard to BMI and other co-morbidities, the similarities between LS and sporadic EC patient cohorts may imply that sporadic and hereditary EC patients share a common risk factor profile.…”

Section: Discussionsupporting

confidence: 80%

“…These studies have suggested that EC women with a family history of CRC or suspected LS appear to be obese less often compared with EC women with no CRC family history (14)(15)(16)(17)(18). However, Lynch mutation carriers with EC have also been reported to be more obese compared with women with sporadic EC (16), whereas others (13) have reported no significant difference in BMI between these two patient groups, which is in line with the results presented in the current study.…”

Section: Discussionsupporting

confidence: 77%

“…However, data are limited on lifestyle, hormonal and medical factors in mutation-verified LS-associated EC. Previous studies reporting BMI in EC-affected LS women have elicited contradictory results (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 83%

See 2 more Smart Citations

Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study

Aaltonen

Staff

Mecklin∥³

et al. 2017

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Data available on lifestyle-associated hormonal and medical factors among endometrial cancer (EC)-affected women who carry the Lynch syndrome (LS) mutation is limited. The aim of the present retrospective case study was to compare the reproductive and medical history, as well as lifestyle-associated factors, among patients with LS and sporadic EC. The study population consisted of 50 verified germline mismatch repair (MMR) gene mutation carriers diagnosed with EC, and 110 sporadic EC patients. Data were collected using postal questionnaires. Apart from the mean age at the time of the EC diagnosis (LS, 48.7 years compared with sporadic patients, 55.2 years; P<0.0001), the characteristics of sporadic and LS EC patients were similar with regard to body mass index (BMI) at age 18, 40 or at the time of the survey, and smoking and alcohol consumption. LS women reported a significantly lower rate of spontaneous abortion (P= 0.043) and also more frequent use of contraceptives (P= 0.004). The prevalence of co-morbidities, including diabetes, atherosclerosis, hypercholesterolemia and hypertension, was similar between the LS and the sporadic groups. A trend for a higher prevalence of endometriosis among mutation carriers was detected (16.0 vs. 8.1%, P= 0.137). As anticipated, the prevalence of gastrointestinal tract, urinary tract and ovarian cancer was higher among the LS women (P<0.0001, P= 0.006 and P= 0.056, respectively). Co-morbidity and lifestyle-associated factors appeared to be comparable among patients with LS and sporadic EC. The reported difference in the use of contraceptives warrants further investigation. Future studies are also required to address the possible association between LS and endometriosis.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 77%

See 1 more Smart Citation

Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study

Aaltonen

Staff

Mecklin∥³

et al. 2017

Molecular and Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…We have previously compared the BMI between the sporadic and hereditary nonpolyposis colorectal cancer (HNPCC)-related endometrial cancer groups and found that there was a difference in the proportion. Especially, among the nonobese patients, the proportion of normal weight was significantly higher in the HNPCC-related group than in the sporadic endometrial cancer group [20]. In this study, no significant difference was identified in BMI and diabetes between the hereditary group (according to the presence of synchronous malignancy) and the sporadic group.…”

Section: Discussionmentioning

confidence: 81%

Survival outcome in endometrial cancer patients according to hereditary predisposition

Yoo

Lim

Son

et al. 2015

Taiwanese Journal of Obstetrics and Gynecology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The doctors in our country were probably not aware of familial cancer risk as in Western countries, while the patients might be uncertain about their relatives' detailed health conditions or history. We were aware of a few studies from Asia that described HNPCC-related EC in Koreans [ 16 33 34 ]. Findings from their studies and our study might raise awareness of this topic in Thai and other Asian populations.…”

Section: Discussionmentioning

confidence: 99%

Synchronous and metachronous malignancy in endometrial cancer patients treated in a tertiary care center of Thailand

2015

View full text Add to dashboard Cite

ObjectiveTo evaluate the prevalence and features of non-endometrial cancers in Thai endometrial cancer (EC) patients.MethodsEC patients treated in our institution were identified and the following data were collected: age, EC stage, histopathology, adjuvant therapy, other cancers, living status, and cause of death.ResultsThe mean age of the 344 patients was 56.8±10.8 years. Fifty (14.5%) had other synchronous and metachronous cancers. Mean ages of the patients with or without other cancers were not significantly different, 55.7±10.04 years versus 57.1±11.0 years, respectively (p=0.358). History of any cancer in the family and tumor in the lower uterine segment were more frequent among the patients with other cancers (6.0% vs. 1.7%, p=0.095; 12.0% vs. 1.0%, p<0.001; respectively). Six patients had ≥2 other cancers. Ovarian, breast, and colon were the three most common other cancers. After a median follow-up of 57.1 months, 18.3% of patients had died: 30.0% of patients with other cancers and 16.3% of those without other cancers. The corresponding EC deaths were 14.0% and 11.2%. The 5-year overall survival was significantly lower in patients who had other cancers: 79.3% (95% confidence interval [CI], 68.3 to 90.3) vs. 86.0% (95% CI, 81.7 to 90.3) than in those without (p=0.023). However, the corresponding disease-specific survival was not significantly different: 85.1% (95% CI, 75.5 to 94.7) compared with 89.0% (95% CI, 85.1 to 92.9), respectively (p=0.514).ConclusionThai EC patients had a high incidence of other cancers. Overall survival of EC patients who had other cancers was worse than those without, while disease-specific survival was not significantly different.

show abstract

Correlation Between Body Mass Index and Prevalence of Hereditary Nonpolyposis Colorectal Cancer in Korean Patients With Endometrial Cancer

Cited by 4 publications

References 16 publications

Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study

Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study

Survival outcome in endometrial cancer patients according to hereditary predisposition

Synchronous and metachronous malignancy in endometrial cancer patients treated in a tertiary care center of Thailand

Contact Info

Product

Resources

About