Clinicopathological Features and the Prevalence of Oxyntic Gland Neoplasm: A Single-center Retrospective Study

Asahara, Hikari; Takao, Toshitatsu; Asahara, Yumiko; Asahara, Masahiro; Motomura, Douglas; Sakaguchi, Hiroya; Yoshizaki, Tetsuya; Ikezawa, Nobuaki; Takao, Madoka; Morita, Yoshinori; Toyonaga, Takashi; Komatsu, Masato; Kushima, Ryoji; Kodama, Yuzo

doi:10.2169/internalmedicine.0552-22

Cited by 5 publications

(11 citation statements)

References 24 publications

(38 reference statements)

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“…This estimation is based on the findings of a large retrospective study of 13,240 upper gastrointestinal endoscopies performed on 7,488 patients at an outpatient internal medicine and endoscopy clinic in Japan (Asahara Clinic, Akashi, Japan). Of note, the authors of the study note that their estimated period prevalence is much larger than previously reported [ 4 ]. Furthermore, cases of OGA reported outside of Japan are exceptionally scarce [ 5 ].…”

Section: Introductionmentioning

confidence: 59%

“…H. pylori does not seem to contribute to the development of gastric-type adenocarcinomas, which include foveolar, pyloric, and fundic-gland type related adenocarcinomas [ 4 , 17 ]. In contrast to H. pylori infection-associated gastric carcinomas, most OGA/GA-FG involve the upper third of the stomach (80%).…”

Section: Discussionmentioning

confidence: 99%

“…They are less frequently observed in the middle third (18%) and lower third (1%) of the stomach [ 10 ]. Furthermore, regardless of infection status, 90% of OGA are identified in non-atrophic gastric mucosa without surrounding inflammation or metaplasia in background mucosa [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some cases of OGA have been noted adjacent to gastric mucosa with PPI-associated histologic changes, such as FGPs and parietal cell hyperplasia [ 10 ]. Notably, PPI use has been identified in up to 37% of patients diagnosed with OGA, with the median duration of use being 646 days (range: 35-5,381 days) [ 4 ]. Among these patients with PPI use, FGPs are identified concurrently in 33% and multiple OGA are identified in 11% [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…As the name suggests, it is a relatively benign epithelial neoplasm that is comprised of chief cells and/or parietal cells with mild nuclear atypia [ 1 , 2 ]. Most recently, according to the 2019 World Health Organization (WHO) Classification of Gastric Carcinomas (5th edition), OGA is distinguished from gastric adenocarcinoma of fundic gland type (GA-FG) by the absence of submucosal invasion [ 3 ], which occurs in approximately half of all cases [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Oxyntic Gland Adenoma in a Patient With Refractory Reflux

Krooks¹,

Thaker²,

Qiu³

et al. 2023

Cureus

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A 58-year-old African American male was referred for endoscopic evaluation due to a persistent nine-year history of reflux. Previous endoscopy nine years ago revealed a small hiatal hernia and chronic gastritis caused by Helicobacter pylori (H. pylori) , which was treated with triple therapy. During the current endoscopic evaluation, findings consistent with reflux esophagitis were identified, along with the discovery of an incidental 6 mm sessile polyp in the gastric fundus. Pathological examination revealed the presence of an oxyntic gland adenoma (OGA). Otherwise, the stomach was found to be unremarkable endoscopically and histologically. OGA is a rare gastric neoplasm that is primarily observed in Japan, with very few reported cases in North America. Studies have suggested a potential association with antacids, while the role of H. pylori in the development of OGA remains controversial. Our patient’s OGA was completely resected during the endoscopy, with no recurrence noted on the three-month follow-up.

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Section: Introductionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxyntic Gland Adenoma in a Patient With Refractory Reflux

Krooks¹,

Thaker²,

Qiu³

et al. 2023

Cureus

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Prevalence, clinical characteristics and treatment outcomes of oxyntic gland neoplasm: a single-center retrospective study

Zhang,

Wang,

Yin

et al. 2024

Scandinavian Journal of Gastroenterology

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Antacids and reflux esophagitis as a risk factor for gastric neoplasm of fundic‐gland type: A retrospective, matched case–control study

Hayasaka,

Hoteya,

Takazawa

et al. 2024

J of Gastro and Hepatol

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Background and AimSince the first report of gastric adenocarcinoma of the fundic‐gland type in 2010, the clinicopathological characteristics of gastric neoplasm of the fundic‐gland type (GNFG) have become clearer; however, their risk factors remain unclear. This exploratory study aimed to identify the risk factors for GNFG.MethodsWe conducted a single‐center, retrospective, matched case–control study using medical information recorded at our health management center from January 2014 to July 2023. During this period, 39 240 people underwent upper gastrointestinal endoscopy. GNFG were extracted as cases and matched to controls, according to age and sex, in a 1:8 ratio, excluding those with a history of gastrointestinal surgery and those with a history or comorbidity of cancer. Univariate analysis was used to compare patient background and endoscopic findings. Multivariable analysis was performed, adjusting for factors with P values < 0.1 and antacid use.ResultsA total of 20 GNFG cases and 160 matched healthy controls were included. In the univariate analysis, only reflux esophagitis was significantly more common in GNFG (40.0% vs 18.1%; P = 0.036). Factors antacids and duodenitis had P values < 0.1. Logistic regression analysis was performed, adjusting for antacids, reflux esophagitis, and duodenitis. Antacids and reflux esophagitis were the independent risk factors for GNFG (odds ratio = 3.68 [95% confidence interval: 1.04–11.91] and 3.25 [95% confidence interval: 1.11–9.35]).ConclusionsAlthough the sample of patients with GNFG was small, antacids and reflux esophagitis were identified as a risk factor. The pathogenesis of antacids and reflux esophagitis may be involved in the development of GNFG.

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Clinicopathological Features and the Prevalence of Oxyntic Gland Neoplasm: A Single-center Retrospective Study

Abstract: Objective We explored the clinicopathological characteristics and disease frequency of oxyntic gland neoplasms (OGNs). Methods We retrospectively evaluated the data of patients pathologically diagnosed with OGN at an internal medicine clinic.

Cited by 5 publications

References 24 publications

Oxyntic Gland Adenoma in a Patient With Refractory Reflux

Oxyntic Gland Adenoma in a Patient With Refractory Reflux

Prevalence, clinical characteristics and treatment outcomes of oxyntic gland neoplasm: a single-center retrospective study

Antacids and reflux esophagitis as a risk factor for gastric neoplasm of fundic‐gland type: A retrospective, matched case–control study

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