Clinicopathological features and prognostic factors of young breast cancers in Eastern Guangdong of China

Wei, Jin-Tao; Huang, Wen‐He; Du, Chenxing; Qiu, Siqi; Wei, Xiaolong; Liu, Jing; Zhang, Guojun

doi:10.1038/srep05360

Cited by 16 publications

(18 citation statements)

References 33 publications

(42 reference statements)

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“…Intensity of nuclear BRCA protein expression was graded as strong (Score 3), moderate (Score 2), weak (Score 1) and absent staining (Score 0). Tumor cells showing Score 0 were considered negative for BRCA expression and Score 1 and above were considered positive for BRCA expression …”

Section: Methodsmentioning

confidence: 99%

“…Tumor cells showing Score 0 were considered negative for BRCA expression and Score 1 and above were considered positive for BRCA expression. 28 IHC scoring was done by two pathologists, blinded to the clinicopathological characteristics. Discordant scores were reviewed together to achieve agreement.…”

Section: Tissue Microarray Construction and Immunohistochemistrymentioning

confidence: 99%

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Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis

Siraj

Alobaisi

et al. 2016

Intl Journal of Cancer

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Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 and BRCA 2 mutations in Middle Eastern population is not fully explored. To characterize the prevalence of BRCA mutations in Middle Eastern breast cancer patients, BRCA mutation screening was performed in 818 unselected breast cancer patients using Capture and/or Sanger sequencing. 19 short tandem repeat (STR) markers were used for founder mutation analysis. In our study, nine different types of deleterious mutation were identified in 28 (3.4%) cases, 25 (89.3%) cases in BRCA 1 and 3 (10.7%) cases in BRCA 2. Seven recurrent mutations identified accounted for 92.9% (26/28) of all the mutant cases. Haplotype analysis was performed to confirm c.1140 dupG and c.4136_4137delCT mutations as novel putative founder mutation, accounting for 46.4% (13/28) of all BRCA mutant cases and 1.6% (13/818) of all the breast cancer cases, respectively. Moreover, BRCA 1 mutation was significantly associated with BRCA 1 protein expression loss (p = 0.0005). Our finding revealed that a substantial number of BRCA mutations were identified in clinically high risk breast cancer from Middle East region. Identification of the mutation spectrum, prevalence and founder effect in Middle Eastern population facilitates genetic counseling, risk assessment and development of cost‐effective screening strategy.

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Section: Methodsmentioning

confidence: 99%

Section: Tissue Microarray Construction and Immunohistochemistrymentioning

confidence: 99%

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis

Siraj

Alobaisi

et al. 2016

Intl Journal of Cancer

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“…Compared with breast cancer in older patients, BCYW usually displays different molecular subtypes that have more aggressive biological characteristics. In addition, BCYW tends to be detected in an advanced stage and carry a poor prognosis, which suggests that the pathogenesis of the disease in young patients is different from that in older patients [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Reproductive Risk Factors Associated with Breast Cancer Molecular Subtypes among Young Women in Northern China

Wang

Zhao

et al. 2020

BioMed Research International

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Purpose. Accumulated evidence suggests that reproductive factors are related to different breast cancer subtypes, but most studies on these relationships are mainly focused on middle-aged and older patients, and it remains unclear how reproductive factors impact different subtypes of breast cancer in young women. Methods. We assessed the relationships between fertility factors and luminal A, luminal B, human epidermal growth factor receptor 2 (HER2)-enriched, and triple-negative breast cancer (TNBC) subtypes in 3792 patients and 4182 controls aged 20–70 years. Data on the reproductive history of the study participants were acquired through face-to-face interviews and questionnaires. We conducted case-control comparisons among tumor subtypes based on estrogen receptor (ER), progesterone receptor (PR), and HER2 statuses using unconditional polychotomous multivariate logistic regression models to compute odds ratios (ORs) and 95% confidence intervals (CIs). Results. Parity was inversely related to both luminal A and luminal B subtypes in young women and older women (all Ptrend<0.05). Later age at first full-term birth was inversely related to the luminal A subtype (Ptrend<0.05) in young women but correlated with an increased risk of the luminal A subtype (Ptrend<0.05) in older women. Parous Chinese women 40 years old or younger who breastfed for 12 months or longer had a lower risk of luminal B and TNBC subtypes than women who never breastfed (OR=0.55, 95% CI 0.36-0.84 and OR=0.52, 95% CI 0.28-0.99, respectively). Conclusions. Our results implied that parity exerted a strong protective effect against luminal A and luminal B subtype breast cancer in young Chinese women, and long-term breastfeeding obviously decreased the risk of luminal B and TNBC subtypes in this population.

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“…Age alone has been shown to be an independent risk factor for breast cancer. Breast cancer in young females is unique in the sense that breast cancer in young females is itself a poor prognosis factor because of greater incidence of advanced stage of disease at presentation with high risk of recurrence 6 . The diagnosis in young females is usually delayed because of low index of, firm breasts hindering clinical and radiological interpretation also causing missing of small breast lumps.…”

Section: Introductionmentioning

confidence: 99%

“…Majority of the patients were having locally advanced III B stage. When very young patients (≤ 30 years) from the study were compared with young patients (30-40 years), very young had advanced malignancies in 50% i.e 6. out of 12 patients in young age group were having stage III B or Stage IV disease (table-3).…”

mentioning

confidence: 99%

Study of Carcinoma Breast in Women under 40 Year of age at A Tertiary Care Hospital in Central India

Dakhore¹,

Mangam²,

Pande³

et al. 2018

IJCMSR

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Breast cancer among young women is a relatively uncommon. Many of the times the diagnosis is delayed in these patients owing to the reluctance of surgeons to subject young females to mammography because of the involved radiation. Current study was conducted to study various aspects of carcinoma breast occurring in patients younger than 40 years of age. Material and Methods: This was a prospective study conducted in the surgery department in which 57 patients less than 40 years of age and diagnosed to be having carcinoma breast were included on the basis of a predefined inclusion and exclusion criteria. The risk factors, clinical presentation, staging and outcome were studied in these cases. Statistical analysis was done using SPSS16.0 version software. P-value less than 0.05 was taken as statistically significant. Results: The most common affected age group was found to be between 35-40 years (56.14%). Common symptoms included lump in breast (100%), pain (19.29%) and discharge (17.54%). Majority of the patients had their first child birth at age less than 20 years. Upper outer quadrant was the most commonly affected site (56.14%) and nipple retraction (19.29%) was the most common sign in the studied cases. Most common tumor and clinical staging were found to be T3 (33.33%) and T III B (28.07%) respectively. Surgery and hormonal therapy were the most common treatment modalities given to these patients (85%). Most common histopathological type was found to be infiltrating ductal carcinoma. Conclusion: Our study concludes that age less than 40 yrs is associated with diagnosis of breast cancer at an advanced stage and young patients presenting with breast lumps should not in any way be considered different from relatively older patients and all standard screening and diagnostic investigations must be carried out for early diagnosis and proper interventions.

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Clinicopathological features and prognostic factors of young breast cancers in Eastern Guangdong of China

Cited by 16 publications

References 33 publications

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis

Reproductive Risk Factors Associated with Breast Cancer Molecular Subtypes among Young Women in Northern China

Study of Carcinoma Breast in Women under 40 Year of age at A Tertiary Care Hospital in Central India

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