Clinicopathological Features and Prognosis of Mucinous Cystic Neoplasm With Ovarian-Type Stroma

Yamao, Kenji; Yanagisawa, Akio; Takahashi, Kuniyuki; Kimura, Wataru; Doi, Ryuichiro; Fukushima, Noriyoshi; Ohike, Nobuyuki; Shimizu, Michio; Hatori, Takashi; Nobukawa, Bunsei; Hifumi, Michio; Kobayashi, Yuji; Tobita, Kosuke; Tanno, Satoshi; Sugiyama, Masanori; Miyasaka, Yoshihiro; Nakagohri, Toshio; Yamaguchi, Taketo; Hanada, Keiji; Abe, Hideki; Tada, Minoru; Fujita, Naotaka; Tanaka, Masao

doi:10.1097/mpa.0b013e3181f749d3

Cited by 250 publications

(136 citation statements)

References 7 publications

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“…The clinical characteristics of the patients are in accordance with the literature [1,2,3,4,5,6], showing a nearly exclusive occurrence in middle-aged females, paucity of symptoms and localization in the tail of the pancreas [1,2,7,8,9]. The spectrum of the histological grade is nearly similar to that of Crippa et al [2].…”

Section: Discussionsupporting

confidence: 74%

Mucinous Cystic Neoplasms of the Pancreas: Definition of Preoperative Imaging Criteria for High-Risk Lesions

Baleur¹,

Couvelard²,

Vullierme³

et al. 2011

Pancreatology

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Section: Discussionsupporting

confidence: 74%

Mucinous Cystic Neoplasms of the Pancreas: Definition of Preoperative Imaging Criteria for High-Risk Lesions

Baleur¹,

Couvelard²,

Vullierme³

et al. 2011

Pancreatology

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“…Another added challenge is the pancreatic duct communication that theoretically is only patent in IPMNs. Despite this, a study showed that at least 15% of pathologically confirmed MCAs had a communication between the lesion and the MD (13).…”

Section: Mcasmentioning

confidence: 99%

“…There are four main types of PCNs: IPMNs, MCAs, serous cystadenomas and solid pseudopapillary neoplasms (Table I). As its name indicates, these lesions have a potential for malignant transformation (10) that broadly ranges from 1% to 36% (11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Intraductal papillary mucinous neoplasms and mucinous cystadenomas: current status and recommendations

Moris

Wallace

2017

Rev Esp Enferm Dig

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The real prevalence of pancreatic cystic lesions remains unknown. The malignant potential of some of these lesions remains a cause for significant concern. Thus, it is mandatory to develop a strategy to clearly discriminate those cysts with a potential for malignant transformation from those that do not carry any significant risk. Intraductal papillary mucinous neoplasms and mucinous cystadenomas are mucinous cystic neoplasms with a known malignant potential that have gained greater recognition in recent years. However, despite the numerous studies that have been carried out, their differential diagnosis among other cysts subtypes and their therapeutic approach continue to be a challenge for clinicians. This review contains a critical approach of the current recommendations and management strategies regarding intraductal papillary mucinous neoplasms and mucinous cystadenomas, as well as highlighting the limitations exposed in current guidelines.

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“…Therefore, surgical resection is advocated as the primary treatment modality. However MCNs have a low prevalence of invasive carcinoma: indeed, in a recent large series, invasive carcinoma accounted for 3.9% to 16% of lesions in the pancreas (6,7) and 10% of those in the liver (8). Recently, the term MCN has been challenged by Albores-Saavedra et al (9,10), who favor dividing MCNs into two types: "pure MCNs" and "nonmucinous cystadenomas of the pancreas with pancreatobiliary phenotype and ovarian-like stroma".…”

mentioning

confidence: 99%

Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression

Shibata

Ohike

Norose

et al. 2017

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Abstract. Background: Pancreatic and hepatic mucinous cyst neoplasms (MCNs) have a malignant potential, but indolent MCNs are not uncommon. Materials and Methods:The pathological and genetic characteristics of resected MCNs (n=15) Mucinous cystic neoplasm (MCN) of the pancreas was first described by Compagno and Oertel in 1978 (1). In the most recent World Health Organization (WHO) Classification of Tumours of the Digestive System (2010) (2), MCN was classified as a distinct entity of cystic neoplasms in both pancreas and liver, and it has been defined as "a cyst-forming epithelial neoplasm, usually showing no communication with the ductal system, composed of cuboidal to columnar, variably mucin-producing epithelium, and associated with ovarian-type subepithelial stroma" (3-5). MCNs tend to occur most often in middle-aged women and are regarded as pre-malignant lesions with significant potential for invasion and metastasis. Therefore, surgical resection is advocated as the primary treatment modality. However MCNs have a low prevalence of invasive carcinoma: indeed, in a recent large series, invasive carcinoma accounted for 3.9% to 16% of lesions in the pancreas (6, 7) and 10% of those in the liver (8). Recently, the term MCN has been challenged by 10), who favor dividing MCNs into two types: "pure MCNs" and "nonmucinous cystadenomas of the pancreas with pancreatobiliary phenotype and ovarian-like stroma". The latter is associated with ovarian-type stroma but is lined by a predominantly nonmucinous and non-dysplastic cuboidal epithelium that probably has no malignant potential. This advocacy may affect the treatment policy and surgical indications for pancreatic and hepatic MCNs. In the present study, we divided pancreatic and hepatic MCNs into mucinous and non-mucinous lesions based on the amount of mucin in the lining epithelium and examined whether or not there was any significant difference in the clinical behavior and biological characteristics between the two. Materials and MethodsFifteen cases of MCN of the pancreas or liver surgically resected between 1994 and 2016 at the Authors' Institutes were examined in the present study. A cystic neoplasm lined by cuboidal to columnar, variably mucin-producing epithelial cells and overlying ovarian-type subepithelial stroma, was regarded as MCN. Based on the findings of a light-microscopic examination of entire or multiple hematoxylin and eosin (H&E)-stained slides (at least five) including 7063 This Αrticle is freely accessible online.

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Clinicopathological Features and Prognosis of Mucinous Cystic Neoplasm With Ovarian-Type Stroma

Abstract: Mucinous cystic neoplasm is a rare but distinctive pancreatic cystic neoplasm with a favorable overall prognosis. All MCNs should be resected to prevent malignant changes but can be observed for an appropriate time when the lesion is small without the presence of mural nodules.

Cited by 250 publications

References 7 publications

Mucinous Cystic Neoplasms of the Pancreas: Definition of Preoperative Imaging Criteria for High-Risk Lesions

Mucinous Cystic Neoplasms of the Pancreas: Definition of Preoperative Imaging Criteria for High-Risk Lesions

Intraductal papillary mucinous neoplasms and mucinous cystadenomas: current status and recommendations

Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression

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