Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study

Abstract

BackgroundThe main aim of the study was to evaluate if patients with oral squamous carcinomas in Northern Norway differ from patients in other countries with regard to clinicopathological characteristics and also study the influence of risk factors. Such a comparison is of demographical interest, and also important for the interpretation of result from studies on prognostic biomarkers.MethodsWe describe clinicopathological characteristics of 133 North Norwegian patients diagnosed with squamous cell carcinoma of the oral cavity in the period 1986–2002, and evaluate the significance of different risk factors.ResultsThe cohort consisted of 69 men and 64 women, giving male/female ratio of 1.1. Forty-seven of the 133 patients (35%) died of the disease within 5 years from diagnosis. There was no significant difference between the genders concerning time to disease specific death, even though men both smoked and drank more alcohol than women. As expected, the strongest predictors for disease specific death were tumour size and the presence of regional lymph node metastasis. We also found that heavy smokers and drinkers presented with more advanced disease, more often localized to the floor of mouth compared to non-smoking and abstinent patients, who more often presented with tumours of the mobile tongue.ConclusionsOur results correlate well with previously published clinicopathological data on comparable cohorts, which is important when considering the applicability of results from biomarker studies performed on this material compared to other cohorts, and vice versa.

Oral squamous cell carcinoma: A 5 years institutional study

“…[13] There has been strong correlation with tobacco usage in various forms. [18][19][20] Buccal mucosa belongs to the gingivobuccal complex of which lower gingivobuccal complex is known as Indian cancer. This is the typical site associated with tobacco chewing.…”

Evaluation of Clinical, Demographic, Pathological, and Molecular Factors with Survival Rate of Patients with Oral Squamous cell Carcinoma in Yazd city During 1998–2008

“…Some studies have shown no relationship between these factors, including Rikardsen. (8) In contrast, Ribeiro (9) claimed that older patients had a worse prognosis for OSCC and Dohlstom (23) who found that younger patients with more invasive OSCC had a worse prognosis.…”

“…(5) Despite the advances in therapeutics and diagnosis, the overall prognosis of OSCC remains unfavorable, with 30% recurrence rates from local or regional disease, 25% for distal metastases, and a 40% 5-year survival rate. (6) The association between the OSCC prognosis and age and sex is controversial, as some studies have not shown such a relationship, (7,8) whereas others have revealed that the prognosis of OSCC is worse in older aged men. (9,10) No relationship between prognosis and smoking and alcohol use was reported in one study, (7) whereas another reported higher mortality rates in cigarette smokers and alcohol drinkers.…”

Improving accuracy of RNA-based diagnosis and prognosis of oral cancer by using noninvasive methods

“…Treatment planning today is based largely on tumor size and the presence and pattern of lymph node invasion [70–72]. Small tumors without lymph node invasion are treated typically with just surgery while small tumors with lymph node invasion and all large tumors are treated with surgery plus radiation and/or chemotherapy [73].…”