Clinicopathological characteristics of gastric carcinoma in young patients

Kim, D. Y.; Ryu, Seong Yeob; Kim, Y. J.; Kim, S. K.

doi:10.1007/s00423-003-0387-1

Cited by 46 publications

(72 citation statements)

References 17 publications

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“…1,2 In an analysis of 107 young patients aged 30 years or less, Nakamura et al 1 from our department reported that the prevalence in female subjects was more frequent than in males, that poorly differentiated adenocarcinoma was more frequent than welldifferentiated adenocarcinoma, and that cancers occurred more frequently in the middle third of the stomach, when compared to cancers in the elderly patients. These observations conform to those reported previously, [1][2][3] and these characteristic clinicopathological features suggest that gastric cancer in young patients occurs under peculiar conditions.…”

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confidence: 93%

“…In several studies, the clinicopathological features of gastric cancer in the young were somewhat different from ours. 1,2,[9][10][11][12][13][14]3,[15][16][17][18][19] With regard to histological type, poorly differentiated adenocarcinoma tends to be more frequent in young adults, [12][13][14]3 however, there is no difference in sex distribution between the young and elderly patients. 9,10,13,14 The discrepancy (b) Fifty-seven-year-old male subject (same case as a).…”

Section: Discussionmentioning

confidence: 99%

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Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

et al. 2007

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The aim of this investigation was to clarify the histological characteristics of gastric cancer in the young. Twenty-three surgically resected specimens of young patients (under 30 years of age; young group) with intramucosal cancer of poorly differentiated type and 42 surgically resected specimens of elderly patients (more than 40 years of age; elderly group) with tumors of the identical depth and histological type were examined. The degree of gastritis and Helicobacter pylori (H. pylori) infection was evaluated according to the updated Sydney system. The incidence of H. pylori infection was significantly higher in the young group than in the elderly group (96 vs 36%, Po0.05). Within the background mucosa, antral chronic inflammatory infiltrates with lymphoid-follicle hyperplasia were more severe, and intestinal metaplasia was less frequent in the young group than in the elderly group. Glandular atrophy was not different between the two groups. Intramucosal gastric adenocarcinomas of poorly differentiated type in the young may be associated with H. pylori infection with antral chronic inflammation with lymphoid-follicle hyperplasia, regardless of the existence of intestinal metaplasia within the background gastric mucosa.

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confidence: 93%

Section: Discussionmentioning

confidence: 99%

Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

et al. 2007

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“…The clinicopathological features of GC in young patients are known to be different from older patients. Features reported more frequently in young patients compared with old patients included female predominance, a significantly higher proportions of Lauren's diffuse-type cancers amongst all tumor types, and poorly differentiated histologic tumor types [15][16][17]. Although some studies have analyzed GC characteristics in young patients [10][11][12], there are currently no reported studies that evaluated GC in extremely young adult patients aged 30 years or younger.…”

Section: Introductionmentioning

confidence: 96%

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

et al. 2014

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Background There is little known about the clinicopathological features and the predictors of survival in extremely young adult patients aged 18-30 years. The aim of this study was to identify clinicopathological features and clinical outcomes for the overall population and for a resectable subgroup of gastric cancer patients aged 18-30 years.Methods From January 2004 to December 2010, 207 patients aged between 18 and 30 years old were diagnosed with gastric cancer and treated at the Asan Medical Center. Clinical findings, histopathological parameters and outcomes were reviewed retrospectively. Patients were further divided into 2 groups according to tumor resectability and then clinicopathological factors that affect tumor resectability and clinical outcomes were analyzed. Results Clinicopathological characteristics of study population showed a predominance of females, undifferentiated tumors, diffuse-type cancers, and advanced gastric cancer. The overall resectability rate was 70.0 % and the median follow-up period was significantly longer in the resectable tumor group (P \ 0.001). Significant prognostic predictors for overall survival in overall patients were higher CEA levels (P = 0.016), larger tumor size (P \ 0.001), unresectability (P = 0.006), and presence of lymphovascular invasion (P = 0.012) in a multivariate analysis. Significant prognostic factors for overall survival in patients with resectable disease included larger tumor size ([4 cm), lymphovascular invasion and higher CEA level in the multivariate analysis. Conclusions Gastric adenocarcinomas in young adult patients aged 18-30 years have unique clinicopathological features. Early detection in a resectable state and subsequent complete resection could increase survival period in young patients with gastric cancer.

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“…An other study showed 18 that young patient do not have worse prognosis than older age patients, if the disease is diagnosed at a reasonably early stage. But most of the cases are not diagnosed on time and present with metastases stage.…”

Section: Discussionmentioning

confidence: 97%

Signet-Ring cell carcinoma of stomach in 13years old boy

Satti¹,

Bhatti²,

Ali³

2013

Int Jour of Biomed Res

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Clinicopathological characteristics of gastric carcinoma in young patients

Abstract: Young patients with gastric carcinoma do not have a worse prognosis than older patients. The important prognostic factor was whether the patients underwent curative resection.

Cited by 46 publications

References 17 publications

Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

Clinical characteristics and outcomes for gastric cancer patients aged 18–30 years

Signet-Ring cell carcinoma of stomach in 13years old boy

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